The Orexin/Hypocretin System: Physiology and Pathophysiology provides an overview of all the recent exciting discoveries in the field as well as new findings such as ligand replacement and gene therapies in the animal models of narcolepsy. Several contributions cover sleep and the multiple systems involved in its regulation. Also covered are clinical applications of orexin/hypocretin agonists and antagonists for various diseases, several experimental methods for orexin/hypoccretin research and their limitations, and careful observations in the appropriate animal models of the disease.
