"Unlike previous classical textbooks of rheumatology in which the clinical and therapeutic approaches to rheumatic disease are discussed, this one is unique in the contributors' ability to integrate the clinical approach to rheumatic disease with the latest biochemical, cellular, and molecular mechanisms at play in these disorders. This approach allows clinical rheumatologists to gain a better understanding of the cellular and molecular biology that underlies the diseases we treat and the therapeutics we use to treat these disorders.."-Doody's Health Science Book Review Journal "It contains many figures of good quality." - Journal of Endocrine Genetics "Unlike previous classical textbooks of rheumatology in which the clinical and therapeutic approaches to rheumatic disease are discussed, this one is unique in the contributors' ability to integrate the clinical approach to rheumatic disease with the latest biochemical, cellular, and molecular mechanisms at play in these disorders. This approach allows clinical rheumatologists to gain a better understanding of the cellular and molecular biology that underlies the diseases we treat and the therapeutics we use to treat these disorders." - Doody Publishing

• I. Molecular Mechanisms in Rheumatic Diseases.- 1 Genetics.- 2 Viruses.- 3 Apoptosis.- 4 Humoral Response.- 5 T-Cell Signaling.- 6 Adhesion and Costimulatory Molecules.- 7 Transcription Factors.- 8 Immune Complexes.- 9 Complement.- 10 Eicosanoids and Other Bioactive Lipids.- 11 Collagens.- II. Cellular Mechanisms in Rheumatic Diseases.- 12 T-Lymphocytes.- 13 B-Lymphocytes.- 14 Monocytes and Macrophages.- 15 Polymorphonuclear Cells.- 16 Synoviocytes.- 17 Chondrocytes.- 18 Osteoblasts and Osteoclasts.- 19 Animal Models.- III. Pathogenesis of Rheumatic Diseases.- 20 Systemic Lupus Erythematosus.- 21 Rheumatoid Arthritis.- 22 Inflammatory Myopathies.- 23 Systemic Sclerosis.- 24 Vasculitis.- 25 Osteoarthritis.- 26 Osteoporosis.- 27 Heritable Disorders of Connective Tissue.- IV. Molecular Aspects of Treatment of Rheumatic Diseases.- 28 Corticosteroids.- 29 Cytotoxic Drugs.- 30 Complement Inhibitors.- 31 Cytokine Response Modifiers.- 32 Restoration of Immune Tolerance.- 33 Metalloproteases and Their Modulation as Treatment in Osteoarthritis.- 34 Gene Therapy.

"Unlike previous classical textbooks of rheumatology in which the clinical and therapeutic approaches to rheumatic disease are discussed, this one is unique in the contributors' ability to integrate the clinical approach to rheumatic disease with the latest biochemical, cellular, and molecular mechanisms at play in these disorders. This approach allows clinical rheumatologists to gain a better understanding of the cellular and molecular biology that underlies the diseases we treat and the therapeutics we use to treat these disorders.."-Doody's Health Science Book Review Journal "It contains many figures of good quality." - Journal of Endocrine Genetics "Unlike previous classical textbooks of rheumatology in which the clinical and therapeutic approaches to rheumatic disease are discussed, this one is unique in the contributors' ability to integrate the clinical approach to rheumatic disease with the latest biochemical, cellular, and molecular mechanisms at play in these disorders. This approach allows clinical rheumatologists to gain a better understanding of the cellular and molecular biology that underlies the diseases we treat and the therapeutics we use to treat these disorders." - Doody Publishing

• I. Molecular Mechanisms in Rheumatic Diseases.- 1 Genetics.- 2 Viruses.- 3 Apoptosis.- 4 Humoral Response.- 5 T-Cell Signaling.- 6 Adhesion and Costimulatory Molecules.- 7 Transcription Factors.- 8 Immune Complexes.- 9 Complement.- 10 Eicosanoids and Other Bioactive Lipids.- 11 Collagens.- II. Cellular Mechanisms in Rheumatic Diseases.- 12 T-Lymphocytes.- 13 B-Lymphocytes.- 14 Monocytes and Macrophages.- 15 Polymorphonuclear Cells.- 16 Synoviocytes.- 17 Chondrocytes.- 18 Osteoblasts and Osteoclasts.- 19 Animal Models.- III. Pathogenesis of Rheumatic Diseases.- 20 Systemic Lupus Erythematosus.- 21 Rheumatoid Arthritis.- 22 Inflammatory Myopathies.- 23 Systemic Sclerosis.- 24 Vasculitis.- 25 Osteoarthritis.- 26 Osteoporosis.- 27 Heritable Disorders of Connective Tissue.- IV. Molecular Aspects of Treatment of Rheumatic Diseases.- 28 Corticosteroids.- 29 Cytotoxic Drugs.- 30 Complement Inhibitors.- 31 Cytokine Response Modifiers.- 32 Restoration of Immune Tolerance.- 33 Metalloproteases and Their Modulation as Treatment in Osteoarthritis.- 34 Gene Therapy.

"Unlike previous classical textbooks of rheumatology in which the clinical and therapeutic approaches to rheumatic disease are discussed, this one is unique in the contributors' ability to integrate the clinical approach to rheumatic disease with the latest biochemical, cellular, and molecular mechanisms at play in these disorders. This approach allows clinical rheumatologists to gain a better understanding of the cellular and molecular biology that underlies the diseases we treat and the therapeutics we use to treat these disorders.."-Doody's Health Science Book Review Journal "It contains many figures of good quality." - Journal of Endocrine Genetics "Unlike previous classical textbooks of rheumatology in which the clinical and therapeutic approaches to rheumatic disease are discussed, this one is unique in the contributors' ability to integrate the clinical approach to rheumatic disease with the latest biochemical, cellular, and molecular mechanisms at play in these disorders. This approach allows clinical rheumatologists to gain a better understanding of the cellular and molecular biology that underlies the diseases we treat and the therapeutics we use to treat these disorders." - Doody Publishing

• I. Molecular Mechanisms in Rheumatic Diseases.- 1 Genetics.- 2 Viruses.- 3 Apoptosis.- 4 Humoral Response.- 5 T-Cell Signaling.- 6 Adhesion and Costimulatory Molecules.- 7 Transcription Factors.- 8 Immune Complexes.- 9 Complement.- 10 Eicosanoids and Other Bioactive Lipids.- 11 Collagens.- II. Cellular Mechanisms in Rheumatic Diseases.- 12 T-Lymphocytes.- 13 B-Lymphocytes.- 14 Monocytes and Macrophages.- 15 Polymorphonuclear Cells.- 16 Synoviocytes.- 17 Chondrocytes.- 18 Osteoblasts and Osteoclasts.- 19 Animal Models.- III. Pathogenesis of Rheumatic Diseases.- 20 Systemic Lupus Erythematosus.- 21 Rheumatoid Arthritis.- 22 Inflammatory Myopathies.- 23 Systemic Sclerosis.- 24 Vasculitis.- 25 Osteoarthritis.- 26 Osteoporosis.- 27 Heritable Disorders of Connective Tissue.- IV. Molecular Aspects of Treatment of Rheumatic Diseases.- 28 Corticosteroids.- 29 Cytotoxic Drugs.- 30 Complement Inhibitors.- 31 Cytokine Response Modifiers.- 32 Restoration of Immune Tolerance.- 33 Metalloproteases and Their Modulation as Treatment in Osteoarthritis.- 34 Gene Therapy.