"The material in this handbook is compiled in such a way that the handbook acts as an intersection of the disciplines of immunology and infectious diseases. Individuals from disciplines on either side of the fence will find this a useful resource for learning about the interplay of host humeral immunity and various infections...this book will provide a useful resource as well as a guide for those interested in learning more about cytokines and chemokines in infectious disease." -Clinical Infectious Diseases

• Introduction: Cytokine Biology Relevant to Infectious Diseases.- I Cytokines in Infectious Diseases.- 1 Leptin: Its Role in Immunomodulation and Susceptibility to Infection.- 2 Cytokine Gene Polymorphism and Host Susceptibility to Infection.- II Cytokines in Gram-Negative Infections.- 3 Proinflammatory and Anti-Inflammatory Cytokines as Mediators of Gram-Negative Sepsis.- 4 Host Response to Pathogenic Bacteria at Mucosal Sites.- 5 Macrophage Migration Inhibitory Factor as a Cytokine of Innate Immunity.- III Cytokines in Gram-Positive Infections.- 6 Cytokine Patterns in Severe Invasive Group A Streptococcal Infections.- 7 Superantigens and Bacterial DNA as Cytokine Inducers in Gram-Positive Sepsis.- 8 Cytokines and Chemokines in Listeriosis.- IV Cytokines in Mycobacterial Infections.- 9 Regulation of Cytokines and Chemokines in Human Mycobacterium tuberculosis Infection.- 10 Cytokines and Chemokines in Protective and Inflammatory Responses to Infection with Nontuberculous Mycobacteria.- 11 Human Interleukin-12—Interferon-? Axis in Protective Immunity to Mycobacteria.- 12 Role of Th1 Cytokines in Host Defenses Against Mycobacterium leprae.- V Cytokines in Other Bacterial Infections.- 13 Possible Role of Molecular Mimicry in Lyme Arthritis.- 14 Cytokine Responses in Patients with Pneumonia.- VI Cytokines in Fungal Infections.- 15 Cytokines and the Host Defense Against Aspergillus fumigatus.- 16 Cytokines of Innate and Adaptive Immunity to Candida albicans.- VII Cytokines in Parasitic Infections.- 17 Th1 and Th2 Cytokines in Leishmaniasis.- 18 Cytokines in the Regulation of Innate and Adaptive Immunity to Toxoplasma gondii.- VIII Cytokines in Viral Infections.- 19 Viroceptors: Virus-Encoded Receptors for Cytokines and Chemokines.- 20 Chemokines and Chemokine Receptors inHIV Infection.- 21 Cytokines in Viral Hepatitis.- IX Cytokines as Therapeutic Agents in Infectious Diseases.- 22 Interferon-? in the Treatment of Infectious Diseases.- 23 Interleukin-2 for the Treatment of HIV Infection.- 24 Clinical Applications of G-CSF and GM-CSF in the Treatment of Infectious Diseases.- X Anticytokine-Based Therapy in Treatment of Infectious Diseases.- 25 Anticytokine Therapies in Patients with Severe Sepsis and Septic Shock.- 26 Intravenous Immunoglobulin Adjunctive Therapy in Patients with Streptococcal Toxic Shock Syndrome and Necrotizing Fasciitis.