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Beskrivning
This volume will provide a contemporary account of advances in chemical carcinogenesis. It will describe major mechanisms of mutagenesis, affects on tumor suppressor genes and proto-oncogenes, and how cell-cycle check points can be by-passed by the "stealth-like" properties of chemical carcinogens.
Historical Overview of Chemical Carcinogenesis.- Multistage Carcinogenesis.- Tobacco Smoke Carcinogens and Lung Cancer.- Mechanisms of Estrogen Carcinogenesis: Modulation by Botanical Natural Products.- Heterocyclic Amines: Potential Human Carcinogens.- Aflatoxins and Hepatocellular Carcinoma.- Metabolic Activation of Chemical Carcinogens.- Detoxication of Chemical Carcinogens and Chemoprevention.- Covalent Polycyclic Aromatic Hydrocarbon-DNA Adducts, Carcinogenicity, Structure and Function.- Oxidation and Deamination of DNA by Endogenous Sources.- Lipid Peroxide-DNA Adducts.- Chemical Carcinogenesis and Epigenetics.- Nucletoide Excision Repair From Bacteria to Humans: Structure-Function Studies.- Base Excision Repair: Role of DNA Polymerase b in Late Stage Base Excision Repair.- O6-Alkylguanine-DNA alkyltransferase.- By-Pass DNA Polymerases.- Mutagenesis: The Outcome of Faulty Replication of DNA.- p53 and Ras-Mutation