East Coast Fever

Ivan Morrison (Edited By) Following graduation in veterinary medicine from the University of Glasgow in 1972 and subsequent completion of a PhD in the same University, Ivan Morrison joined the newly established International Laboratory for Research on Animal Diseases (ILRAD) in Nairobi in 1975. His initial research focused on immunity and genetics of susceptibility to trypanosome infections. In the early 1980s, he switched his attention to the bovine protozoan parasite Theileria parva and built up a research group to study the mechanisms of immunity to this parasite, with the eventual aim of devising novel methods of vaccination. The research demonstrated that immunity is mediated by T cell responses and specifically identified the importance of CD8 T cells both in providing protection and determining the strain specificity of immunity. This work laid much of the foundation for subsequent research on subunit vaccine development for this parasite. In 1990, Morrison returned to the UK as Head of the Division of Immunology at the Institute for Animal Health, where he was involved in immunological research on a number pathogens of livestock. He joined the University of Edinburgh in 2002 and re-established a research group working on immunity to Theileria parasites. His recent research has continued to focus on understanding how different components of the immune response to Theileria contribute to immunity or enhanced pathology and how defined parasite antigens can be used to induce immunity.Phillip Toye (Edited By) Philip Toye is currently a Principal Scientist at the International Livestock Research Institute (ILRI), Nairobi. His research background is in the immunology and molecular biology of infectious diseases, and he has worked primarily on East Coast fever for over 20 years. His research has focused on the development of vaccines and diagnostic assays, including work aimed at elucidating the composition of the Muguga cocktail, the immune response it stimulates and its commercialisation. This has been extended more recently into the interaction between host genetic background and response to pathogens, in particular the resistance of cattle to disease caused by T. parva. He graduated with a degree in Veterinary Science from the University of Queensland, Australia. He completed a PhD in immunoparasitology from the University of Adelaide, followed by a postdoctoral appointment to the Harvard Medical School.

• 1: A brief history of discovery of Theileria parva and related species of Theileria in cattle. 2: The economic and social impact of disease caused by Theileria parva 3: Development of Theileria parva in the tick and mammalian hosts. 4: The pathogenesis of East Coast fever 5: Theileria parva in the African buffalo (Syncerus caffer) 6: Disease caused by Theileria parva in southern Africa 7: Heritable resistance to disease caused by Theileria parva 8: Theileria diagnostics and species definition 9: Theileria parva genomics and genotypic polymorphism 10: The cell biology of the Theileria-leukocyte relationship 11: Immunity to Theileria parva 12: Immunisation against East Coast fever using live parasites: Development of an infection and treatment vaccine 13: The commercialisation of a vaccine for Theileria parva based on infection and treatment 14: Treatment of disease caused by Theileria parva 15: Properties and control of the tick vectors of Theileria parva 16: Future research priorities