Bone and Osteoarthritis

Series Editors of Topics in Bone Biology are: Professors Felix Bronner, PhD - University of Connecticut Health Center, Farmington, CT, USA, and Dr Mary C. Farach-Carson, PhD - the Department of Biology, University of Delaware, Newark, DE, USA. In this fourth volume, the Series Editors are joined by a co-editor with special expertise in the volume topic, Dr Richard F. Loeser, MD, the Robert S. Katz, MD - Joan and Paul Rubschlager Presidential Professor of Osteoarthritis Research in the Department of Internal Medicine, Section of Rheumatology with a conjoint appointment in the Department of Biochemistry, Rush University, Chicago, IL, USA.

• The Pathogenesis of Osteoarthritis.- The Role of Bone in the Development of Osteoarthritis.- Cytokines, Growth Factors, and Bone-Derived Factors in Cartilage.- The Synovium and Its Role in Osteoarthritis.- Cartilage Matrix Destruction.- Anabolic Mediators of Cartilage Healing.- Chondrocyte Hypertrophy and Apoptosis at the Cartilage-Bone Interface.- Genetic and Epigenetic Aspects of Osteoarthritis.- Animal Models.- Biomechanical Aspects: Joint Injury and Osteoarthritis.- Novel Osteoarthritis Therapeutics.