This book constitutes the refereed proceedings of the 15th International Conference on Information Security Practice and Experience, ISPEC 2019, held in Kuala Lumpur, Malaysia, in November 2019.The 21 full and 7 short papers presented in this volume were carefully reviewed and selected from 68 submissions. They were organized into the following topical sections: Cryptography I, System and Network Security, Security Protocol and Tool, Access Control and Authentication, Cryptography II, Data and User Privacy, Short Paper I, and Short Paper II.