Florence Ruggiero is Director of Research at the CNRS and Director of the Institute of Functional Genomics of Lyon at the “Ecole Normale Supérieure de Lyon”. Her primary research interest, as a young investigator, was the analysis of cell-collagen interactions and collagen-receptors. Since then, the collagen super family became “her family” and she has authored over a hundred publications in the matrix biology field. Her lab developed new methods to produce recombinant collagens and derived-domains in various expression systems including plants to identify binding partners and to resolve extracellular protein networks. Her lab is currently investigating the functional role of unconventional collagens in development, regeneration and disease using zebrafish as a model organism. She is a past councilor of the International Society for Matrix Biology and again serves as a councilor of French Society for Matrix Biology. She was honored to serve as Chair for the Collagen Gordon ResearchConference in 2017.

• ​Chapter 1:  Introduction to the collagen superfamily.- Chapter 2: Collagen IV-related disease.- Chapter 3: Articular collagens related diseases.- Chapter 4: Collagens as new players of nervous system disease.- Chapter 5: Collagens and EDS.- Chapter 6: Collagens and dystrophic epidermolysis bullosa.- Chapter 7: Collagen-related myopathies: pathogenic mechanisms and prospective therapies.- Chapter 8: Procollagen trafficking and its implicaitons in Osteogenesis Imperfecta.

Florence Ruggiero is Director of Research at the CNRS and Director of the Institute of Functional Genomics of Lyon at the “Ecole Normale Supérieure de Lyon”. Her primary research interest, as a young investigator, was the analysis of cell-collagen interactions and collagen-receptors. Since then, the collagen super family became “her family” and she has authored over a hundred publications in the matrix biology field. Her lab developed new methods to produce recombinant collagens and derived-domains in various expression systems including plants to identify binding partners and to resolve extracellular protein networks. Her lab is currently investigating the functional role of unconventional collagens in development, regeneration and disease using zebrafish as a model organism. She is a past councilor of the International Society for Matrix Biology and again serves as a councilor of French Society for Matrix Biology. She was honored to serve as Chair for the Collagen Gordon ResearchConference in 2017.

• ​Chapter 1:  Introduction to the collagen superfamily.- Chapter 2: Collagen IV-related disease.- Chapter 3: Articular collagens related diseases.- Chapter 4: Collagens as new players of nervous system disease.- Chapter 5: Collagens and EDS.- Chapter 6: Collagens and dystrophic epidermolysis bullosa.- Chapter 7: Collagen-related myopathies: pathogenic mechanisms and prospective therapies.- Chapter 8: Procollagen trafficking and its implicaitons in Osteogenesis Imperfecta.

Florence Ruggiero is Director of Research at the CNRS and Director of the Institute of Functional Genomics of Lyon at the “Ecole Normale Supérieure de Lyon”. Her primary research interest, as a young investigator, was the analysis of cell-collagen interactions and collagen-receptors. Since then, the collagen super family became “her family” and she has authored over a hundred publications in the matrix biology field. Her lab developed new methods to produce recombinant collagens and derived-domains in various expression systems including plants to identify binding partners and to resolve extracellular protein networks. Her lab is currently investigating the functional role of unconventional collagens in development, regeneration and disease using zebrafish as a model organism. She is a past councilor of the International Society for Matrix Biology and again serves as a councilor of French Society for Matrix Biology. She was honored to serve as Chair for the Collagen Gordon ResearchConference in 2017.

• ​Chapter 1:  Introduction to the collagen superfamily.- Chapter 2: Collagen IV-related disease.- Chapter 3: Articular collagens related diseases.- Chapter 4: Collagens as new players of nervous system disease.- Chapter 5: Collagens and EDS.- Chapter 6: Collagens and dystrophic epidermolysis bullosa.- Chapter 7: Collagen-related myopathies: pathogenic mechanisms and prospective therapies.- Chapter 8: Procollagen trafficking and its implicaitons in Osteogenesis Imperfecta.