Hybrid PET/MR Neuroimaging

Ana M. Franceschi, M.D., Ph.D.Associate Professor of Radiology Division of NeuroradiologyDonald and Barbara Zucker School of Medicine at Hofstra/Northwell The Feinstein Institutes for Medical Research Dinko Franceschi, M.D.Associate Professor of Radiology Division Chief of Nuclear Medicine and PET ImagingStony Brook Cancer CenterRenaissance School of Medicine at Stony Brook University

“This resource presents a helpful introduction to PETMR and is of interest to both the trainee and general radiologist. The enthusiasm of the authors for this novel imaging technique is clearly evident throughout the book and could serve as inspiration to the aspiring trainee to follow a dual-speciality training pathway in both nuclear medicine and neuroradiology.” (Ruth Whitehead and Mark Igra, RAD Magazine, April, 2023)

• SECTION I: Introdcution to PET/MR.- Introduction to PET/MR.- SECTION II: Public Health and Economic Implications.- Utility of PET/MRI in Private Practice.- SECTION III: Physics of PET/MR Systems.- Physics of PET/MR Systems.- SECTION IV: Overview of Hot Lab and Cyclotron.- Overview of Hot Lab and Cyclotron.- SECTION V: Radiotracers in Neurologic PET/MRI.- FDG Metabolic Imaging.- Amyloid Dementia Imaging.- TAU Dementia Imaging.- Amino Acid Tumor Imaging.- FDOPA Dopaminergic Imaging.- DASB Serotonin Receptor Imaging.- FEPPA Microglial Activation Imaging.- [150]-H2O/CO2 Perfusion Imaging.- Fluciclovine (Axumin) glioma imaging.- Ga68 Dotatate neuroendocrine imaging.- Radiotracers in development.- SECTION VI: Dementia and Neurodegenerative Disease.- Alzheimer’s disease.- MCI and dementia therapeutics.- Posterior cortical atrophy.- Dementia with Lewy Body.- Behavioral variant FTD (Pick’s disease).- Semantic dementia.- Logopenic PPA.- Agrammatic PPA.- Progressive supranuclear palsy.- Multisystem atrophy.- Corticobasal degeneration.- Creutzfeld-Jacob disease.- Normal pressure hydrocephalus.- Crossed cerebellar diaschisis.- SECTION VII: Epilepsy Localization.- Seizure Focus Localization.- Developmental.- Acquired.- SECTION VIII: Brain Tumors.- Diagnosis.- Primary Brain Neoplasms.- Metastatic Disease.- Treatment Planning.- Treatment Response.- SECTION IX: Inflammatory and Infectious CNS Disorders.- Meningitis.- Encephalitis.- CNS Inflammatory Disease.- Demyelinating Disease.- Vasculitis.- SECTION X: Hybrid Imaging in Head and Neck.- Role of PET/MR in tumor staging.- Mucosal and nodal disease in the head and neck.- Extranodal disease in the head and neck.- Metastatic disease in the head and neck.- Salivary gland pathology.- Orbital pathology.- SECTION XI: Spine PET/MR.- Neoplastic Disease.- Non-Neoplastic.- SECTION XII: Vascular Hybrid Imaging.- Ischemic Disease.- Aneurysms and Vascular Malformations.- Genetic Disorders.- Perfusion and PET.- Advanced MR Techniques.- SECTIONXIII: Future Trends.- Artificial Intelligence.- Utility of AI in Dementia/Neuroimaging