Clinical Nuclear Medicine in Neurology

Andrea Varrone is a Specialist in Nuclear Medicine and holds a PhD in Functional Radioisotopic Imaging. He is also an Associate Professor of Nuclear Medicine and Research Group Leader for Molecular Imaging in Neurodegenerative Disorders, with affiliation to the Department of Clinical Neuroscience at Karolinska Institutet. Dr. Varrone is an expert on PET imaging for patients with movement disorders. He his currently employed at H. Lundbeck A/S, Valby, Denmark.Valentina Garibotto is a Specialist in Nuclear Medicine, currently working as a Senior Physician at the Geneva University Hospitals and group leader of the Neuroimaging and Innovative Molecular Tracer Laboratory at Geneva University. Prof. Garibotto has extensive clinical expertise in molecular neuroimaging and has coordinated multiple clinical trials on the validation of novel PET tracers for the diagnostic assessment and physiopathological investigation of cognitive disturbances.Silvia Morbelli is an Associate Professor of Nuclear Medicine at the University of Genoa and is currently working at San Martino University Hospital. She holds a PhD in Applied Neurosciences and has made valuable contributions concerning the use of neuroimaging tools as diagnostic and prognostic biomarkers in the earliest and preclinical stages of Neurodegenerative Dementia and Parkinsonian Syndromes. She is currently the Chair of the Neuroimaging Committee, European Association of Nuclear Medicine.

“The great interest of this book derives from the fact that, in 200 pages enriched by 100 figures, it analyzes a myriad of exemplary challenging cases in which diagnostic neuroimaging, based on optimized user-independent methods, allowed a correct final diagnosis. … I strongly suggest the acquisition of this publication not only to nuclear physicians and neuro-radiologists but also to all the professionals interested to better understand cerebral diseases. I believe that this book should be present in all the libraries of departments dealing with the brain.” (Luigi Mansi, European Journal of Nuclear Medicine and Molecular Imaging, January 13, 2022)

• SECTION I - Nuclear Medicine cases of dementia and movement disorders.-  Case 1: Mild cognitive impairment (MCI) – [18F]FDG and amyloid PET.-  Case 2: Alzheimer´s disease - [18F]FDG, tau and amyloid PET.-  Case 3: Alzheimer´s disease – Behavioural variant.-  Case 4: Parkinson´s disease with onset as MCI.-  Case 5: Parkinson´s disease with vascular abnormalities.-  Case 6: Parkinson´s disease with left-side spasticity.-  Case 7: Holmes tremor.-  Case 8: Multiple system atrophy with DAT SPECT and [18F]FDG PET.-  Case 9: Progressive supranuclear palsy: Richardson syndrome and Parkinsonian variants.-  Case 10: Progressive supranuclear palsy.-  Case 11: Corticobasal syndrome - [18F]FDG and amyloid PET.-  Case 12: Huntington´s disease with atypical onset.-  Case 13: Huntington´s disease with psychiatric onset.-  Case 14: Creutzfeldt–Jakob disease with pathological confirmation.-  SECTION II - Nuclear Medicine cases of epilepsy and encephalitis. Case 15: Temporal lobe epilepsy.-  Case 16: Ictal imaging in partial status epilept cus.-  Case 17: Focal pharmacoresistant epilepsy.- Case 18: Post-surgical epilepsy.- Case 19: Thalamic hamartoma.- Case 20: Autoimmune encephalitis with unusual antibodies.- Case 21: Psychiatric presentation of anti-N-methyl-D-aspartate receptor (NMDAR) limbic encephalitis.- Case 22: Hashimoto encephalitis. SECTION III -  Nuclear Medicine cases of brain tumors.-  Case 23: Pseudoresponse in a case of Glioblastoma multiforme.- Case 24: Progressive Glioma.- Case 25: Isocitrate dehydrogenase (IDH) wild-type glioma.- Case 26: Post-operative meningioma.- Case 27: Meningioma with difficult delineation on MRI.- Case 28: Optic nerve sheath meningioma (ONSM).-  Case 29: Primary brain lymphoma.- Case 29: Neurolymphomatosis.- Case 30: Atypical teratoid rhabdoid tumor (ATRT).- Case 31: Brain metastatis – progression/recurrence vs. radionecrosis.- Case 32: Tumefactive plaques.- SECTION IV  -  PET/MRI and challenging cases.- Case 33: Typical AD with discordant biomarkers.- Case 34: Fronto-temporal dementia, behavioural variant, mimicker.- Case 35: Creutzfeldt–Jakob disease.- Case 36: Amyotrophic lateral sclerosis.- Case 37: Epilepsy.- Case 38: Limbic encephalitis.