Koren Ofir, MDInterventional CardiologistFellow in Structural Interventional CardiologySmidt Heart Institute, Cedars-Sinai Medical CenterDr. Koren is an interventional cardiologist who focuses on coronary and structural interventions. He holds an academic at the Bruce and Ruth Rappaport Faculty of Medicine at the Technion-institute of Technology in Israel. He taught for many years and was repeatedly awarded as an outstanding lecturer by faculty students and colleagues. He conducted multiple national trials as a prime investigator and served as a SI for major international studies. Dr. Koren published numerous manuscripts and book chapters in leading peer-review journals, presented them at major international conferences, and was awarded for his research achievements.Raj Makkar, MDDirector, Interventional Cardiology DivisionDirector, Interventional Cardiology Research ProgramVice President, Cardiovascular Innovation and InterventionExecutive Director, Cardiac Interventional ServicesSmidt Heart Institute, Cedars-Sinai Medical CenterRaj Makkar, MD is a world-renowned leading expert in interventional cardiology and is one of the most widely cited researchers on the management of valvular heart disease. He has performed the greatest number of transcatheter valve implantation (TAVI) procedures in the world and has led the field in advancing the procedure to ensure the best outcomes for patients. In 2020, he performed the most transcatheter mitral valve repair procedures with the MitraClip system in the United States and is the national principal investigator for mitral valve replacement research studies. He has authored over 500 manuscripts, abstracts and book chapters in peer-reviewed literature including practice-changing contributions in the New England Journal of Medicine and the Lancet.Vivek Patel, MSSmidt Heart Institute, Cedars-Sinai Medical CenterVivek Patel is a Biomedical Engineer who has a keen interest in Transcatheter structural cardiovascular devices and Imaging. Vivek has a strong level of knowledge, a diverse skill set, and solid research capabilities in structural heart disease intervention. Vivek Patel has contributed and reviewed multiple manuscripts for the leading peer-review journals. He has provided a key role in the national CT Imaging Core lab in multiple clinical Transcatheter devices studies.Danon Kaewkes, MDDepartment of Medicine, Faculty of Medicine, Khon Kaen UniversityDr. Kaewkes is Senior Interventional cardiologist Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. He expertise in TAVR and edge-to-edge mitral repair procedure and published multiple manuscripts in leading PR journals. Dr. Kaewkes was a fellow in interventional cardiology, Cedars-Sinai, LA, California during the years 2019-2021. Jubin Joseph, MD PhDInterventional CardiologyJubin Joseph is an interventional cardiologist with expertise in structural intervention. He completed undergraduate medical education at both Cambridge and Oxford University before undertaking post-graduate clinical training in Oxford and London. He has broad experience across the whole range of structural interventions & since 2020 has been working at Cedars Sinai Medical Center, Los Angeles with a particular focus on mitral and tricuspid intervention.  Dr Hasan JilaihawiAssociate Professor of Medicine and Cardiothoracic SurgeryDirector, NYU Imaging CorelabDirector of Research, Heart Valve CenterInterventional CardiologistNYU Langone HealthHasan Jilaihawi, MD, is an Interventional Cardiologist, Associate Professor of Medicine and Cardiothoracic Surgery and the Director of the Imaging Corelab at NYU Langone Health. He is involved in all aspects of cardiology, with a special interest in innovative methods of imaging the heart, complex percutaneous coronary intervention and device and patient selection within the novel field of transcatheter valve therapies. His international reputation in the field has earned him the prestigious responsibility of running the CT corelab for the pivotal US trial of the Portico device, the world’s first fully repositionable and retrievable TAVR, as well as the CT corelab for China’s first TAVR trial. He has authored more than 100 peer-reviewed manuscripts in journals including the New England Journal of Medicine, the Journal of the American College of Cardiology and the European Heart Journal.

• ​Section 1: Aortic Valve.- Chapter 1. TAVR in Bicuspid Aortic Insufficiency following Valve-Sparing Aortic Root Replacement (Valve-in-Graft).- Chapter 2. Coronary access protection technique (Chimney) during TAVR.- Chapter 3. TAVR in Patient with a Large Apical Left Ventricular Thrombus.- Chapter 4. Acute embolic occlusion of the left coronary artery following TAVR.- Chapter 5. Sapien-3 THV dislodgment during balloon inflation.- Chapter 6. Balloon burst during a Sapien-3 THV inflation.- Chapter 7. THV embolization due to Non-captured pacing.- Chapter 8. Reduction in Left coronary artery flow after Valve-in-Valve TAVR procedure.- Chapter 9. Two-Valves solution for unstable self-expandable valve and aortic root aneurysm.- Chapter 10. Bailout solution in a case of an embolized balloon expandable THV.- Chapter 11. Extreme horizontal aorta in bicuspid AS patient.- Chapter 12. Aortic root rupture following AV valvuloplasty and THV deployment.- Chapter 13. Displacement of a THV toward ascending aorta due to premature ventricular contraction.- Chapter 14. TAVR in Aortic root homograft and Challenging Access.- Chapter 15. TAVR Valve dislodgement due to retrieval of the guidewire.- Chapter 16. TAVR in SOV Pseudoaneurysm.- Chapter 17. TAVR in Previous 2TAVRs in SAVR (Subclavian Access).- Chapter 18.  Clip steerable delivery system malfunction.- Chapter 19. LVOT Obstruction after TAVR.- Chapter 20. LM Obstruction following ViV procedure involving Mitroflow.- Chapter 21. Closure of subvalvular fistula and occlusion of RCA.- Chapter 22. Cardiac Arrest due to Protamine Sulphate.- Chapter 23. LVOT obstruction following TMVR treated with self-expanding THV.- Chapter 24. TAVR in large aortic annulus.- Chapter 25. TAVR in situs inversus.- Chapter 26. TAVR in Bicuspid aortic valve.- Section 2: Mitral Valve.- Chapter 27. Multiple edge-to-edge percutaneous repairs for severe  mitral and tricuspid regurgitation.- Chapter 28. TMVR Valve Dislodgement.- Chapter 29. Air embolization during the MitraClip procedure.- Chapter 30. Valve-in-Valve in severe Mitral annulus calcification.- Chapter 31. Apical Aneurysm Closure.- Chapter 32. Multiple clips for severe Mitral regurgitation.- Chapter 33. Early degeneration of surgical mitral valve.- Chapter 34. Mitral clip raptured chordae.- Chapter 35. Rare anomaly of Azygos continuation of the inferior vena cava.- Chapter 36. Mitral docks and leaflet thrombosis.- Chapter 37. Patient with MDOCK AND EVOQUE.- Section 3: Tricuspid Valve.- Chapter 38. Transcatheter Tricuspid and Mitral Valve Replacement in a Patient with Cardiogenic Shock.- Chapter 39. Detachment of TR clip,

Koren Ofir, MDInterventional CardiologistFellow in Structural Interventional CardiologySmidt Heart Institute, Cedars-Sinai Medical CenterDr. Koren is an interventional cardiologist who focuses on coronary and structural interventions. He holds an academic at the Bruce and Ruth Rappaport Faculty of Medicine at the Technion-institute of Technology in Israel. He taught for many years and was repeatedly awarded as an outstanding lecturer by faculty students and colleagues. He conducted multiple national trials as a prime investigator and served as a SI for major international studies. Dr. Koren published numerous manuscripts and book chapters in leading peer-review journals, presented them at major international conferences, and was awarded for his research achievements.Raj Makkar, MDDirector, Interventional Cardiology DivisionDirector, Interventional Cardiology Research ProgramVice President, Cardiovascular Innovation and InterventionExecutive Director, Cardiac Interventional ServicesSmidt Heart Institute, Cedars-Sinai Medical CenterRaj Makkar, MD is a world-renowned leading expert in interventional cardiology and is one of the most widely cited researchers on the management of valvular heart disease. He has performed the greatest number of transcatheter valve implantation (TAVI) procedures in the world and has led the field in advancing the procedure to ensure the best outcomes for patients. In 2020, he performed the most transcatheter mitral valve repair procedures with the MitraClip system in the United States and is the national principal investigator for mitral valve replacement research studies. He has authored over 500 manuscripts, abstracts and book chapters in peer-reviewed literature including practice-changing contributions in the New England Journal of Medicine and the Lancet.Vivek Patel, MSSmidt Heart Institute, Cedars-Sinai Medical CenterVivek Patel is a Biomedical Engineer who has a keen interest in Transcatheter structural cardiovascular devices and Imaging. Vivek has a strong level of knowledge, a diverse skill set, and solid research capabilities in structural heart disease intervention. Vivek Patel has contributed and reviewed multiple manuscripts for the leading peer-review journals. He has provided a key role in the national CT Imaging Core lab in multiple clinical Transcatheter devices studies.Danon Kaewkes, MDDepartment of Medicine, Faculty of Medicine, Khon Kaen UniversityDr. Kaewkes is Senior Interventional cardiologist Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. He expertise in TAVR and edge-to-edge mitral repair procedure and published multiple manuscripts in leading PR journals. Dr. Kaewkes was a fellow in interventional cardiology, Cedars-Sinai, LA, California during the years 2019-2021. Jubin Joseph, MD PhDInterventional CardiologyJubin Joseph is an interventional cardiologist with expertise in structural intervention. He completed undergraduate medical education at both Cambridge and Oxford University before undertaking post-graduate clinical training in Oxford and London. He has broad experience across the whole range of structural interventions & since 2020 has been working at Cedars Sinai Medical Center, Los Angeles with a particular focus on mitral and tricuspid intervention.  Dr Hasan JilaihawiAssociate Professor of Medicine and Cardiothoracic SurgeryDirector, NYU Imaging CorelabDirector of Research, Heart Valve CenterInterventional CardiologistNYU Langone HealthHasan Jilaihawi, MD, is an Interventional Cardiologist, Associate Professor of Medicine and Cardiothoracic Surgery and the Director of the Imaging Corelab at NYU Langone Health. He is involved in all aspects of cardiology, with a special interest in innovative methods of imaging the heart, complex percutaneous coronary intervention and device and patient selection within the novel field of transcatheter valve therapies. His international reputation in the field has earned him the prestigious responsibility of running the CT corelab for the pivotal US trial of the Portico device, the world’s first fully repositionable and retrievable TAVR, as well as the CT corelab for China’s first TAVR trial. He has authored more than 100 peer-reviewed manuscripts in journals including the New England Journal of Medicine, the Journal of the American College of Cardiology and the European Heart Journal.

• ​Section 1: Aortic Valve.- Chapter 1. TAVR in Bicuspid Aortic Insufficiency following Valve-Sparing Aortic Root Replacement (Valve-in-Graft).- Chapter 2. Coronary access protection technique (Chimney) during TAVR.- Chapter 3. TAVR in Patient with a Large Apical Left Ventricular Thrombus.- Chapter 4. Acute embolic occlusion of the left coronary artery following TAVR.- Chapter 5. Sapien-3 THV dislodgment during balloon inflation.- Chapter 6. Balloon burst during a Sapien-3 THV inflation.- Chapter 7. THV embolization due to Non-captured pacing.- Chapter 8. Reduction in Left coronary artery flow after Valve-in-Valve TAVR procedure.- Chapter 9. Two-Valves solution for unstable self-expandable valve and aortic root aneurysm.- Chapter 10. Bailout solution in a case of an embolized balloon expandable THV.- Chapter 11. Extreme horizontal aorta in bicuspid AS patient.- Chapter 12. Aortic root rupture following AV valvuloplasty and THV deployment.- Chapter 13. Displacement of a THV toward ascending aorta due to premature ventricular contraction.- Chapter 14. TAVR in Aortic root homograft and Challenging Access.- Chapter 15. TAVR Valve dislodgement due to retrieval of the guidewire.- Chapter 16. TAVR in SOV Pseudoaneurysm.- Chapter 17. TAVR in Previous 2TAVRs in SAVR (Subclavian Access).- Chapter 18.  Clip steerable delivery system malfunction.- Chapter 19. LVOT Obstruction after TAVR.- Chapter 20. LM Obstruction following ViV procedure involving Mitroflow.- Chapter 21. Closure of subvalvular fistula and occlusion of RCA.- Chapter 22. Cardiac Arrest due to Protamine Sulphate.- Chapter 23. LVOT obstruction following TMVR treated with self-expanding THV.- Chapter 24. TAVR in large aortic annulus.- Chapter 25. TAVR in situs inversus.- Chapter 26. TAVR in Bicuspid aortic valve.- Section 2: Mitral Valve.- Chapter 27. Multiple edge-to-edge percutaneous repairs for severe  mitral and tricuspid regurgitation.- Chapter 28. TMVR Valve Dislodgement.- Chapter 29. Air embolization during the MitraClip procedure.- Chapter 30. Valve-in-Valve in severe Mitral annulus calcification.- Chapter 31. Apical Aneurysm Closure.- Chapter 32. Multiple clips for severe Mitral regurgitation.- Chapter 33. Early degeneration of surgical mitral valve.- Chapter 34. Mitral clip raptured chordae.- Chapter 35. Rare anomaly of Azygos continuation of the inferior vena cava.- Chapter 36. Mitral docks and leaflet thrombosis.- Chapter 37. Patient with MDOCK AND EVOQUE.- Section 3: Tricuspid Valve.- Chapter 38. Transcatheter Tricuspid and Mitral Valve Replacement in a Patient with Cardiogenic Shock.- Chapter 39. Detachment of TR clip,

Koren Ofir, MDInterventional CardiologistFellow in Structural Interventional CardiologySmidt Heart Institute, Cedars-Sinai Medical CenterDr. Koren is an interventional cardiologist who focuses on coronary and structural interventions. He holds an academic at the Bruce and Ruth Rappaport Faculty of Medicine at the Technion-institute of Technology in Israel. He taught for many years and was repeatedly awarded as an outstanding lecturer by faculty students and colleagues. He conducted multiple national trials as a prime investigator and served as a SI for major international studies. Dr. Koren published numerous manuscripts and book chapters in leading peer-review journals, presented them at major international conferences, and was awarded for his research achievements.Raj Makkar, MDDirector, Interventional Cardiology DivisionDirector, Interventional Cardiology Research ProgramVice President, Cardiovascular Innovation and InterventionExecutive Director, Cardiac Interventional ServicesSmidt Heart Institute, Cedars-Sinai Medical CenterRaj Makkar, MD is a world-renowned leading expert in interventional cardiology and is one of the most widely cited researchers on the management of valvular heart disease. He has performed the greatest number of transcatheter valve implantation (TAVI) procedures in the world and has led the field in advancing the procedure to ensure the best outcomes for patients. In 2020, he performed the most transcatheter mitral valve repair procedures with the MitraClip system in the United States and is the national principal investigator for mitral valve replacement research studies. He has authored over 500 manuscripts, abstracts and book chapters in peer-reviewed literature including practice-changing contributions in the New England Journal of Medicine and the Lancet.Vivek Patel, MSSmidt Heart Institute, Cedars-Sinai Medical CenterVivek Patel is a Biomedical Engineer who has a keen interest in Transcatheter structural cardiovascular devices and Imaging. Vivek has a strong level of knowledge, a diverse skill set, and solid research capabilities in structural heart disease intervention. Vivek Patel has contributed and reviewed multiple manuscripts for the leading peer-review journals. He has provided a key role in the national CT Imaging Core lab in multiple clinical Transcatheter devices studies.Danon Kaewkes, MDDepartment of Medicine, Faculty of Medicine, Khon Kaen UniversityDr. Kaewkes is Senior Interventional cardiologist Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. He expertise in TAVR and edge-to-edge mitral repair procedure and published multiple manuscripts in leading PR journals. Dr. Kaewkes was a fellow in interventional cardiology, Cedars-Sinai, LA, California during the years 2019-2021. Jubin Joseph, MD PhDInterventional CardiologyJubin Joseph is an interventional cardiologist with expertise in structural intervention. He completed undergraduate medical education at both Cambridge and Oxford University before undertaking post-graduate clinical training in Oxford and London. He has broad experience across the whole range of structural interventions & since 2020 has been working at Cedars Sinai Medical Center, Los Angeles with a particular focus on mitral and tricuspid intervention.  Dr Hasan JilaihawiAssociate Professor of Medicine and Cardiothoracic SurgeryDirector, NYU Imaging CorelabDirector of Research, Heart Valve CenterInterventional CardiologistNYU Langone HealthHasan Jilaihawi, MD, is an Interventional Cardiologist, Associate Professor of Medicine and Cardiothoracic Surgery and the Director of the Imaging Corelab at NYU Langone Health. He is involved in all aspects of cardiology, with a special interest in innovative methods of imaging the heart, complex percutaneous coronary intervention and device and patient selection within the novel field of transcatheter valve therapies. His international reputation in the field has earned him the prestigious responsibility of running the CT corelab for the pivotal US trial of the Portico device, the world’s first fully repositionable and retrievable TAVR, as well as the CT corelab for China’s first TAVR trial. He has authored more than 100 peer-reviewed manuscripts in journals including the New England Journal of Medicine, the Journal of the American College of Cardiology and the European Heart Journal.

• ​Section 1: Aortic Valve.- Chapter 1. TAVR in Bicuspid Aortic Insufficiency following Valve-Sparing Aortic Root Replacement (Valve-in-Graft).- Chapter 2. Coronary access protection technique (Chimney) during TAVR.- Chapter 3. TAVR in Patient with a Large Apical Left Ventricular Thrombus.- Chapter 4. Acute embolic occlusion of the left coronary artery following TAVR.- Chapter 5. Sapien-3 THV dislodgment during balloon inflation.- Chapter 6. Balloon burst during a Sapien-3 THV inflation.- Chapter 7. THV embolization due to Non-captured pacing.- Chapter 8. Reduction in Left coronary artery flow after Valve-in-Valve TAVR procedure.- Chapter 9. Two-Valves solution for unstable self-expandable valve and aortic root aneurysm.- Chapter 10. Bailout solution in a case of an embolized balloon expandable THV.- Chapter 11. Extreme horizontal aorta in bicuspid AS patient.- Chapter 12. Aortic root rupture following AV valvuloplasty and THV deployment.- Chapter 13. Displacement of a THV toward ascending aorta due to premature ventricular contraction.- Chapter 14. TAVR in Aortic root homograft and Challenging Access.- Chapter 15. TAVR Valve dislodgement due to retrieval of the guidewire.- Chapter 16. TAVR in SOV Pseudoaneurysm.- Chapter 17. TAVR in Previous 2TAVRs in SAVR (Subclavian Access).- Chapter 18.  Clip steerable delivery system malfunction.- Chapter 19. LVOT Obstruction after TAVR.- Chapter 20. LM Obstruction following ViV procedure involving Mitroflow.- Chapter 21. Closure of subvalvular fistula and occlusion of RCA.- Chapter 22. Cardiac Arrest due to Protamine Sulphate.- Chapter 23. LVOT obstruction following TMVR treated with self-expanding THV.- Chapter 24. TAVR in large aortic annulus.- Chapter 25. TAVR in situs inversus.- Chapter 26. TAVR in Bicuspid aortic valve.- Section 2: Mitral Valve.- Chapter 27. Multiple edge-to-edge percutaneous repairs for severe  mitral and tricuspid regurgitation.- Chapter 28. TMVR Valve Dislodgement.- Chapter 29. Air embolization during the MitraClip procedure.- Chapter 30. Valve-in-Valve in severe Mitral annulus calcification.- Chapter 31. Apical Aneurysm Closure.- Chapter 32. Multiple clips for severe Mitral regurgitation.- Chapter 33. Early degeneration of surgical mitral valve.- Chapter 34. Mitral clip raptured chordae.- Chapter 35. Rare anomaly of Azygos continuation of the inferior vena cava.- Chapter 36. Mitral docks and leaflet thrombosis.- Chapter 37. Patient with MDOCK AND EVOQUE.- Section 3: Tricuspid Valve.- Chapter 38. Transcatheter Tricuspid and Mitral Valve Replacement in a Patient with Cardiogenic Shock.- Chapter 39. Detachment of TR clip,