This book constitutes the thoroughly refereed post-workshop proceedings of the 22nd Chinese Lexical Semantics Workshop, CLSW 2021, held in Nanjing, China in May 2021.The 68 full papers and 4 short papers included in this volume were carefully reviewed and selected from 261 submissions. They are organized in the following topical sections: Lexical Semantics and General Linguistics; Natural Language Processing and Language Computing; Cognitive Science and Experimental Studies; Lexical Resources and Corpus Linguistics.