Hereditary Gastric and Breast Cancer Syndrome

Giovanni Corso MD, PhDBreast surgeon at the European Institute of Oncology in Milan, Italy, and senior researcher at the University of Milan, Italy. Elected president of the European Cancer Prevention Organization (ECPO), and next editor-in-chief of the European Journal of Cancer Prevention.Paolo Veronesi, MDDirector of the Breast Surgery Division at the European Institute of Oncology in Milan, Italy, and full professor in surgery at the University of Milan, Italy. President of the Umberto Veronesi Foundation (FUV).Franco Roviello, MDDirector of the Surgical Oncology Unit at the Hospital “Le Scotte” in Siena, Italy, and full professor in surgery at the University of Siena, Italy. President of the Italian Society of Surgical Oncology (SICO).

• Part I. Epidemiology.- Family History and the Risk of Breast and Gastric Cancer.- Worldwide CDH1 Germline Mutation Frequency and the Transhormesis Hypothesis.- Hereditary Lobular Breast Cancer: A Newly Defined Syndrome.- Part II. Genetics.- Genetic Counseling and Prevention in Families at High Risk for HDGC and Other Hereditary Syndromes.- CTNNA1, a New HDGC Gene: Inactivating Mechanisms and Driven Phenotypes.- Revisiting the Biological and Clinical Impact of CDH1 Missense Variants.- Other Syndromes and Genes Associated with Gastric Cancer Predisposition.- Computer-Assisted Interpretation of Cancer-Predisposing Variants.- Part III. Pathology.- Histopathology of Hereditary Diffuse Gastric Cancer: From Grossing and 3D Microscopy to Immunophenotypic and Molecular Profiling.- HER2 Testing in Breast and Gastric Cancer with CDH1 Germline Mutations.- Pathology and Somatic Alterations in Hereditary Lobular Breast Cancers.- Part IV. Endoscopy and Imaging.- Endoscopy:Is there Anything New?.- Endoscopic Surveillance and Pathology of Biopsies in CDH1, CTNNA1 and HDGC-Like Families.- Lobular Carcinoma of the Breast: Spectrum of Imaging Findings and New Emerging Technologies on the Horizon.- Part V. Surgery.- Prophylactic Total Gastrectomy: Techniques.- Prophylactic Total Gastrectomy: How Many?.- Hereditary Lobular Breast Cancer Syndrome: Role of Surgery.- Breast Reconstruction.- Part VI. New Issues.- Psychological Burden and Preferences in CDH1 Mutation Carriers: Beyond the Cancer Diagnosis.- Drug Repurposing in Gastric Cancer: Current Status and Future Perspectives.- The Chemoprevention of Hereditary Diffuse Gastric Cancer.- Malformations and Malformative Syndromes Associated with CDH1.- Hereditary Breast Cancer Non-CDH1 Associated.- Part VII. Patient Advocacy.- My Hereditary Gastric Cancer.- Hereditary Breast Cancer Syndrome, My Experience.- Part VIII. Miscellaneous.- β-Hemoglobinopathies and Early Onset of Cancers in Adulthood. Epidemiology in Southeastern Asia & Brunei with Emphasis for Prevention and Treatment.