This book constitutes the proceedings of the 22nd International Conference on Smart Card Research and Advanced Applications, CARDIS 2023, held in Amsterdam, The Netherlands, during November 14–16, 2023.The 13 full papers presented in this volume were carefully reviewed and selected from 28 submissions. They were organized in topical sections as follows: fault attacks; side-channel analysis; smartcards & efficient Implementations; and side-channel & neural networks.