This book constitutes the proceedings of the 19th International Conference on Design Science Research in Information Systems and Technology, DESRIST 2024, which was held in Trollhättan, Sweden, during June 3–5, 2024.The 30 full papers presented in this book were carefully reviewed and selected from 69 submissions. The papers are divided into the following topical sections: DSR for a resilient world (theme track); general track; DSR methods and education; DSR in practice; and emerging topics in DSR.