Paul A. Iaizzo, PhD, FHRSProfessor of Surgery, Biomedical Engineering, Biomedical Informatics and Computational Biology, Physiology University of Minnesota420 Delaware St SEB172 Mayo, MMC 195Minneapolis, MN 55455Michael D. Eggen, PhD Adjunct Assistant Professor of Surgery, University of MinnesotaSr. Research Manager, Medtronic CRHFMedtronic 8200 Coral Sea St. NEMounds View, MN 55112-4391Tinen L. Iles, PhDAssistant Professor of Surgery, Biomedical Informatics and Computational BiologyUniversity of Minnesota420 Delaware St SEB172 Mayo, MMC 195Minneapolis, MN 55455

• Foreword by Tim Laske.- Section 1: Introduction.- Clinical Cardiac Electrophysiology: An Overview of its Evolution.- Section 2: Overview.- Basic Cardiac Electrophysiology: Excitable Membranes.- Cardiac Action Potentials, Ion Channels, and Gap Junctions.- Anatomy and Physiology Overview of the Cardiac Conduction System.- The Surface Electrocardiogram and Clinical Cardiac Electrophysiology.- Section 3: Disease States and Therapies.- Catheter Ablation of Cardiac Arrhythmias.- Cardiac Ablative Technologies.- Cardiac Anatomy Relative to Ablation Therapies.- Electroporation Ablative Therapy as a Clinical Tool: An Old Technology Revisited .- Pacing and Defibrillation.- Cardiac Resynchronization Therapy.- Section 4: Methods and Models.- Cardiac Cellular Electrophysiological Modeling.- Cardiac Monophasic Action Potentials: Endocardial, Epicardial, and Transmural Recordings.- Impact of Geometric Simplifications on Cardiac Computational Models of Electrophysiology to Assess Cardiac Resynchronization Therapy.- Cardiac Tissue Engineering: A Pathway for Repair.- Isolated Tissue Models.- The Utility of Large Mammalian Isolated Heart Models to Perform Multi-Channel Recordings and Analyses of Cardiac Rhythmicity and Conductivity In Vitro.- Probing Small Animal Models for Pathogenesis of Cardiac Arrhythmias Using Optical Mapping.- The Use of Large Animal Models for Cardiac Electrophysiology Studies.- Optical Mapping and Calcium Imaging.- Electrophysiology of Single Cardiomyocytes: Patch Clamp and Other Recording Methods.- Functional Stimulation of Cardiac Tissue and the Electrode Tissue Interface: Laboratory Tutorials and Exercises.- Engineering Principles of Lead Extraction.- Innovation in Clinical Care: Case Studies from Contemporary Cardiac Electrophysiology.

Paul A. Iaizzo, PhD, FHRSProfessor of Surgery, Biomedical Engineering, Biomedical Informatics and Computational Biology, Physiology University of Minnesota420 Delaware St SEB172 Mayo, MMC 195Minneapolis, MN 55455Michael D. Eggen, PhD Adjunct Assistant Professor of Surgery, University of MinnesotaSr. Research Manager, Medtronic CRHFMedtronic 8200 Coral Sea St. NEMounds View, MN 55112-4391Tinen L. Iles, PhDAssistant Professor of Surgery, Biomedical Informatics and Computational BiologyUniversity of Minnesota420 Delaware St SEB172 Mayo, MMC 195Minneapolis, MN 55455

• Foreword by Tim Laske.- Section 1: Introduction.- Clinical Cardiac Electrophysiology: An Overview of its Evolution.- Section 2: Overview.- Basic Cardiac Electrophysiology: Excitable Membranes.- Cardiac Action Potentials, Ion Channels, and Gap Junctions.- Anatomy and Physiology Overview of the Cardiac Conduction System.- The Surface Electrocardiogram and Clinical Cardiac Electrophysiology.- Section 3: Disease States and Therapies.- Catheter Ablation of Cardiac Arrhythmias.- Cardiac Ablative Technologies.- Cardiac Anatomy Relative to Ablation Therapies.- Electroporation Ablative Therapy as a Clinical Tool: An Old Technology Revisited .- Pacing and Defibrillation.- Cardiac Resynchronization Therapy.- Section 4: Methods and Models.- Cardiac Cellular Electrophysiological Modeling.- Cardiac Monophasic Action Potentials: Endocardial, Epicardial, and Transmural Recordings.- Impact of Geometric Simplifications on Cardiac Computational Models of Electrophysiology to Assess Cardiac Resynchronization Therapy.- Cardiac Tissue Engineering: A Pathway for Repair.- Isolated Tissue Models.- The Utility of Large Mammalian Isolated Heart Models to Perform Multi-Channel Recordings and Analyses of Cardiac Rhythmicity and Conductivity In Vitro.- Probing Small Animal Models for Pathogenesis of Cardiac Arrhythmias Using Optical Mapping.- The Use of Large Animal Models for Cardiac Electrophysiology Studies.- Optical Mapping and Calcium Imaging.- Electrophysiology of Single Cardiomyocytes: Patch Clamp and Other Recording Methods.- Functional Stimulation of Cardiac Tissue and the Electrode Tissue Interface: Laboratory Tutorials and Exercises.- Engineering Principles of Lead Extraction.- Innovation in Clinical Care: Case Studies from Contemporary Cardiac Electrophysiology.

Paul A. Iaizzo, PhD, FHRSProfessor of Surgery, Biomedical Engineering, Biomedical Informatics and Computational Biology, Physiology University of Minnesota420 Delaware St SEB172 Mayo, MMC 195Minneapolis, MN 55455Michael D. Eggen, PhD Adjunct Assistant Professor of Surgery, University of MinnesotaSr. Research Manager, Medtronic CRHFMedtronic 8200 Coral Sea St. NEMounds View, MN 55112-4391Tinen L. Iles, PhDAssistant Professor of Surgery, Biomedical Informatics and Computational BiologyUniversity of Minnesota420 Delaware St SEB172 Mayo, MMC 195Minneapolis, MN 55455

• Foreword by Tim Laske.- Section 1: Introduction.- Clinical Cardiac Electrophysiology: An Overview of its Evolution.- Section 2: Overview.- Basic Cardiac Electrophysiology: Excitable Membranes.- Cardiac Action Potentials, Ion Channels, and Gap Junctions.- Anatomy and Physiology Overview of the Cardiac Conduction System.- The Surface Electrocardiogram and Clinical Cardiac Electrophysiology.- Section 3: Disease States and Therapies.- Catheter Ablation of Cardiac Arrhythmias.- Cardiac Ablative Technologies.- Cardiac Anatomy Relative to Ablation Therapies.- Electroporation Ablative Therapy as a Clinical Tool: An Old Technology Revisited .- Pacing and Defibrillation.- Cardiac Resynchronization Therapy.- Section 4: Methods and Models.- Cardiac Cellular Electrophysiological Modeling.- Cardiac Monophasic Action Potentials: Endocardial, Epicardial, and Transmural Recordings.- Impact of Geometric Simplifications on Cardiac Computational Models of Electrophysiology to Assess Cardiac Resynchronization Therapy.- Cardiac Tissue Engineering: A Pathway for Repair.- Isolated Tissue Models.- The Utility of Large Mammalian Isolated Heart Models to Perform Multi-Channel Recordings and Analyses of Cardiac Rhythmicity and Conductivity In Vitro.- Probing Small Animal Models for Pathogenesis of Cardiac Arrhythmias Using Optical Mapping.- The Use of Large Animal Models for Cardiac Electrophysiology Studies.- Optical Mapping and Calcium Imaging.- Electrophysiology of Single Cardiomyocytes: Patch Clamp and Other Recording Methods.- Functional Stimulation of Cardiac Tissue and the Electrode Tissue Interface: Laboratory Tutorials and Exercises.- Engineering Principles of Lead Extraction.- Innovation in Clinical Care: Case Studies from Contemporary Cardiac Electrophysiology.