This book constitutes the refereed proceedings of the 22nd International Conference on Ethical and Social Impacts of Information and Communication Technology, ETHICOMP 2025, held in Lisbon, Portugal, during September 17–19, 2025.The 51 full papers presented in this volume were carefully reviewed and selected from 165 submissions. The papers are organized in the following topical sections: Ethics, Society; Eduction; Systems; and Security.