The 93 full papers included in this book were carefully reviewed and selected from 187 submissions. They were organized in topical sections as follows:Part I: Machine Learning in Neuroscience; Functional Evaluation of Neuromotor and Cognitive Disorders; Intelligent Systems for the Study and Support of Youth Mental Health; Socio-Cognitive, Affective and Physiological Computing; Intelligent Systems for Assessment, Treatment, and Assistance in early stages of Alzheimer; Neuroprosthesis, Ethics; and European Culture and Technology Lab;Part II: Machine Learning in Computer Vision and Robotics; Robotics; Bio-Inspired Computing Approaches; Social and Civil Engineering through Human AI Translations; Explainable, Robust and Trustworthy Machine Learning and its Applications; Learning tools to lecture; and Other Applications.