This book constitutes the refereed proceedings of the First International Conference on Machine Intelligence and Data Science, MIDAS 2025 held in Paralakhemundi, India, during March 21–22, 2025.The 34 full papers and 6 short papers included in this book were carefully reviewed and selected from 136 submissions. They are organized into the following topical sections: Intelligent Computational Models for Multimedia Understanding and Trusted Digital Systems; Learning-Driven Paradigms for Healthcare Analytics and Biomedical Intelligence; Data-Centric Intelligence for Enterprise Analytics, Financial Systems, and Sustainable Innovation; and Emerging Intelligent Systems for Secure Computing, Autonomous Technologies, and Smart Environments.