Nitric Oxide and Cancer: Pathogenesis and Therapy

Dr. Benjamin Bonavida is a professor at UCLA's David Geffen School of Medicine for the Department of Microbiology, Immunology, & Molecular Genetics. His other appointments include being a member of the Department of Defense Congressionally Directed Medical Research Program, Member of the National Cancer Institute's SPORE Program, member of the International Scientific Advisory Board of the Israel Cancer Research Foundation, to name a few. He's currently a scientific reviewer for several journals and a member of editorial boards including Journal of Clinical Immunology, International Journal of Oncology, and Cancer Biotherapy & Radiopharmaceuticals.

"It describes the current perceptions on the role of NO. in cancer and a possible therapeutic application of NO. in the clinical practice. ... The book also presents several mechanisms of multiple effects and potential of NO. for therapeutic use under optimal conditions. It can be recommended to all readers who are interested in the pathogenesis and therapy of cancer." (Darina Slamenova, Neoplasma, Vol. 62 (6), 2015)

• Inflammation-associated Carcinogenesis Involved Interaction Between with iNOS/NO and WNT/beta-catenin.- NO and Genomic Stability.- Targeting Hyponitroxia in Cancer Therapy.- Mechanism of NO-dependent Regulation of Invasion and Metastasis.- NO Role in Protumorigenesis and Hypoxia.- Impacts of S-nitrosylation in Cancer.- S-nitrosylation of Cancer Cells.- Role of S-nitrosylation in Cancer Metastasis.- NO Immunity and Cancer.- Regulation of Anti-tumor Responses by NO.- NO Immune Modulation and Tumor Growth.- Role of NO in Chemo-immune Resistance.- Emerging Role of NO-mediated Therapeutics.- PDT and NO.- Regulation of Cell Death by NO.- Discovery and Development of RRx-001.- Nitric Oxide Coagulation and Cancer.- Neutrosphyngomyelinase 2.