Metal Allergy

Jennifer Chen is currently an assistant professor at Stanford University School of Medicine. She holds an MD from Johns Hopkins University and has completed a Howard Hughes Medical Institute fellowship at Stanford University School of Medicine. Dr. Chen has published 25 articles and authored 4 book chapters. Her areas of interest include allergic contact dermatitis and medical dermatology. She regularly delivers presentations at international meetings and has served as a consultant for the Women's Health and Contemporary Pediatrics magazines, Greatist, Reader's Digest, and the local news. Jacob Thyssen has worked in clinical dermatology for more than 10 years and holds PhD and DmSci degrees from the University of Copenhagen in Denmark, where he is currently an associate professor. He has authored 250 articles, 12 book chapters and 2 textbooks (on patch testing and filaggrin proteins). Dr. Thyssen has received international awards for his research, including the LEO Pharma Research Foundation for best investigator aged below 45 years in the Nordic countries. His research has focused on atopic and contact dermatitis, allergies, and the skin barrier. He has been a research fellow in the USA, visiting Harvard Medical School and UCSF. Dr. Thyssen is a regular speaker at international meetings. He enjoys treating patients with dermatitis and metal allergies on a daily basis in the Gentofte Clinic in Copenhagen, Denmark.

“Metal Allergy is a tempting read for arthroplasty surgeons, especially metal-on-metal enthusiasts and those struggling with trunnionosis. The hardcover book is presented to the usual high Springer standard. Chapter authors are mostly from the USA and continental Europe. … This book will mainly be of interest to orthopaedic surgeons dealing with metal bearings.” (J. Brockwell, The Bone & Joint Journal, Vol. 100-B (11), November, 2018)​

• Preface.- I Metal: Overview.- 1 Use of metals in our society.- 2 Methods to detect metal composition: XRF, SEM, ICP-MS.- 3 Metal corrosion.- 4 EN1811.- 5 EN ISO 17075.- 6 Regulation of metal exposure to prevent allergy.- II Metals, skin and the immune system.- 7 Deposition of metals on the skin and spot tests.- 8 Penetration of metals through the skin barrier.- 9 Innate immune system response: Toll-like receptors.- 10 Acquired immunity: T cell response.- 11 Tolerance development.- 12 Metal patch testing.-13  Lymphocyte proliferation assays.- III Allergens.- 14 Aluminum.- 15 Berylium.- 16 Chromium.- 17 Cobalt.- 18 Copper.-  19 Gold.-  20 Nickel.- 21 Palladium.- 22 Titanium.- 23 Other metals: iron, platinum, tin, zinc.-  IV Common Sources of Metal Exposure.-  24 Metals in every day devices.- 25 Metals in tools and the workplace.- 26 Metals in cosmetics.-  27 Metals in coins.-  28 Metals in the diet.-  V Hypersensitivity to Metallic Implants.- 29Orthopedic Metal Implants.-  30 Cardiovascular Metal Implants.- 31 Dental Metal Implants.- 32 Other Metal Implants: Gynecological, Neurovascular.- 33 Diagnostic work-up of patients with metal implant failure.-  VI Metal Allergy in Select Patient Populations.- 34 Metal allergy in children.- 35 Metal allergy in atopic dermatitis.- 36 Metal allergy in Asia.-  VII Uncommon Manifestations of Metal Allergy.- 37 Metal allergy in asthma.- 38 Metal allergy in palmoplantar pustulosis.- 39 Metal allergy in endometriosis.- 40 Systemic Nickel Allergy Syndrome.- Future research areas.- Subject Index.