Uptake and Trafficking of Protein Toxins

Inbunden, Engelska, 2017

Del i serien Current Topics in Microbiology and Immunology

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Beskrivning

This volume focuses on the transport of medically relevant bacterial protein toxins into mammalian cells, and on novel pharmacological strategies to inhibit toxin uptake.

Produktinformation

Utgivningsdatum:2017-12-19
Mått:155 x 235 x 20 mm
Vikt:565 g
Format:Inbunden
Språk:Engelska
Serie:Current Topics in Microbiology and Immunology
Antal sidor:256
Upplaga:17001
Förlag:Springer International Publishing AG
ISBN:9783319588919

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Mer om författaren

Holger BarthInstitute of Pharmacology and Toxicology, University of Ulm Medical Center, Albert-Einstein-Allee 11, 89081 Ulm, Germany, e-mail: holger.barth@uni-ulm.de

Innehållsförteckning

Two feet on the membrane: uptake of clostridial neurotoxins.- Receptors and binding structures for Clostridium difficile Toxins A and B.- Cell entry of C3 exoenzyme from Clostridium botulinum.- Receptor-binding and up-take of binary actin-ADP-ribosylating toxins.- Clostridial Binary Toxins: Basic Understandings that Include Cell-Surface Binding and an Internal “Coup de Grace”.- Host cell chaperones Hsp70/Hsp90 and peptidyl-prolyl cis/trans isomerases are required for the membrane translocation of bacterial ADP-ribosylating toxins.- Multivalent Inhibitors of Channel-Forming Bacterial Toxins.- Toxin Transport by A-B Type of Toxins in Eukaryotic Target Cells and its inhibition by Positively Charged Heterocyclic Molecules.