This book constitutes the refereed proceedings of the Second International Conference on Digital Transformation and Global Society, DTGS 2017, held in St. Petersburg, Russia, in June 2017.The 34 revised full papers and three revised short papers presented were carefully reviewed and selected from 134 submissions. The papers are organized in topical sections on eSociety: social media analysis; eSociety: ICTs in education and science; eSociety: legal, security and usability issues; ePolity: electronic governance and electronic participation; ePolity: politics of cyberspace; eCity: urban planning and smart cities; eHealth: ICTs in public health management; eEconomy and eFinance: finance and knowledge management.