Gregory of Nyssa’s »De hominis opificio«, a treatise on Genesis 1,26, is a key text for the understanding of Eastern Christian anthropology. In the 14th century a Serb translated the 31 chapters of this opus from Greek. The earliest dissemination of the text seems to have been restricted to Athos and the region of Montenegro, Macedonia and Western Bulgaria. The present volume contains a critical edition of the Slavonic text together with the Greek original, an extensive commentary in which text-critical, linguistic and translation-related issues are examined and a glossary with a considerable number of »athesaurista«.