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      Mass Spectrometry for Lipidomics

      Methods and Applications

      AvMichal Holcapek,Kim Ekroos

      Inbunden, Engelska, 2023

      2 616 kr

      Beställningsvara. Skickas inom 11-20 vardagar. Fri frakt över 249 kr.

      Beskrivning

      Mass Spectrometry for Lipidomics All-in-one guide to successful lipidomic analysis, combining the latest advances and best practices from academia, industry, and clinical research Mass Spectrometry for Lipidomics presents a systematic overview of lipidomic analysis, covering established standards of lipid analysis, available technology, and key lipid classes, as well as applications in basic research, medicine, pharma, and the food industry. Through connecting recent technological advances with key application areas, this unique guide bridges the gap between academia and industry by translating the vast body of knowledge that has been gained in the past decade into much-needed practical advice for novices as well as routine users. Edited by the president and vice-president of the International Lipidomics Society with contributions from the top experts in lipid analysis, Mass Spectrometry for Lipidomics covers a wide range of key topics, including: Aspects of sample preparation, separation methods, different mass spectrometry modes, as well as identification and quantitation, including the use of bioinformatics tools for data analysisIdentification, quantitation and profiling of lipids in different types of biological samplesAnalytical approaches for all major classes of biological lipids, from fatty acids to phospholipids to sterolsNovel applications in biological research, clinical diagnostics, as well as food and crop scienceFor analytical chemists, biochemists, clinical chemists, and analytical laboratories and hospitals, Mass Spectrometry for Lipidomics presents a comprehensive and authoritative overview of the subject, with unmatched expertise from practicing professionals actively involved in the latest research.

      Produktinformation

      • Utgivningsdatum:2023-03-22
      • Mått:170 x 244 x 47 mm
      • Vikt:1 729 g
      • Format:Inbunden
      • Språk:Engelska
      • Antal sidor:752
      • Förlag:Wiley-VCH Verlag GmbH
      • ISBN:9783527350155

      Utforska kategorier

      • Kemi inom Naturvetenskap och teknik

      Mer om författaren

      Michal Holèapek obtained his Ph.D. at the University of Pardubice (Czech Republic), where he is now a full professor of analytical chemistry. His research focus is mass spectrometry and its coupling with liquid chromatography and supercritical fluid chromatography. He is the current vice-president for conferences of the International Lipidomics Society.Kim Ekroos is the founder and CEO of Lipidomics Consulting Ltd. He received his Ph.D. degree in biology from the Technical University in Dresden (Germany). He is the current president of the International Lipidomics Society.

      Innehållsförteckning

      • Preface xiii1 Introduction to Lipidomics 1Harald C. Köfeler, Kim Ekroos, and Michal HolcapekPart I Analytical Methodologies in Lipidomics 132 Preanalytics for Lipidomics Analysis 15Gonçalo Vale and Jeffrey G. McDonald3 Direct Infusion (Shotgun) Electrospray Mass Spectrometry 41Marcus Höring and Gerhard Liebisch4 Liquid Chromatography – and Supercritical Fluid Chromatography – Mass Spectrometry 91Michal Holcapek, Ondrej Peterka, Michaela Chocholousková, and Denise Wolrab5 Mass Spectrometry Imaging of Lipids 117Shane R. Ellis and Jens Soltwisch6 Ion Mobility Spectrometry 151Kaylie I. Kirkwood, Melanie T. Odenkirk, and Erin S. Baker7 Structural Characterization of Lipids Using Advanced Mass Spectrometry Approaches 183Josef Cvacka, Vladimír Vrkoslav, and stepán Strnad8 Lipidomic Identification 227Harald Köfeler9 Lipidomics Quantitation 255Michaela Chocholousková, Denise Wolrab, Ondrej Peterka, Robert Jirásko, and Michal Holcapek10 The Past and Future of Lipidomics Bioinformatics 271Dominik Kopczynski, Daniel Krause, Fadi Al Machot, Dominik Schwudke, Nils Hoffmann, and Robert AhrendsPart II Lipidomic Analysis According to Lipid Categories and Classes 29111 Fatty Acids: Structural and Quantitative Analysis 293Dong Hao Wang and J. Thomas Brenna12 Quantitation of Oxylipins in Biological Samples, Focusing on Plasma, and Urine 317Valerie B. O'Donnell, Ginger L. Milne, Marina S. Nogueira, Martin Giera, and Nils Helge Schebb13 Mass Spectrometry for Analysis of Glycerolipids 351Wm. Craig Byrdwell14 Lipidomic Analysis of Glycerophospholipid Molecular Species in Biological Samples 395Xianlin Han15 Sphingolipids 425Lukas Opalka, Lisa Schlicker, and Roger Sandhoff16 Sterol Lipids 481William J. Griffiths, Eylan Yutuc, and Yuqin Wang17 Bile Acids 509Sebastian Simstich and Günter FaulerPart III Lipidomic Applications 53118 Lipidomic Profiling in a Large-Scale Cohort 533Daisuke Saigusa19 Cancer Lipidomics – From the Perspective of Analytical Chemists 545Denise Wolrab, Ondrej Peterka, Michaela Chocholousková, and Michal Holcapek20 Lipidomics in Clinical Diagnostics 557Jayashree Selvalatchmanan, Markus R. Wenk, and Anne K. Bendt21 Lipidomics in Food Industry and Nutrition 585Danilo Donnarumma, Giuseppe Micalizzi, Luigi Mondello, and Paola Dugo22 Lipidomics in Plant Science 601Zoong Lwe Zolian, Yu Song, P. A. D. B. Vinusha Wickramasinghe, and Ruth Welti23 Lipidomics in Multi-Omics Studies 625Bjoern Titz, Oksana Lavrynenko, and Nikolai V. Ivanov24 Tracer Lipidomics 641Jonas Dehairs, Ine Koeken, Lake-Ee Quek, Andrew Hoy, Bart Ghesquière, and Johannes V. Swinnen25 Mass Spectrometry for Lipidomics: Methods and Applications – Aging and Alzheimer's Disease 657Kevin Huynh, Habtamu B. Beyene, Tingting Wang, Corey Giles, and Peter J. Meikle26 Lipidomics in Cell Biology 669Noemi Jiménez-Rojo, Fabrizio Vacca, and Howard Riezman27 Microbial Lipidomics 689Masahiro Ueda, Nobuyuki Okahashi, and Makoto AritaIndex 705
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