The editors have assembled an eclectic collection of articles that give a solid overview of the current state-of-the-art in small molecule-nucleic acid targeting... As indicated by its general title, this latest contribution to the Topics in Current Chemistry series is not meant to be comprehensive. Rather, a variety of topics at the forefront of small molecule-nucleic acid biochemistry are discussed in great detail. This volume will be of considerable use both to researchers in the field and to those who wish to move into this exciting area. Paul J. Hergenrother, University of Illinois at Urbana-Champaign, JA059748D, J.AM.CHEM.SOC., Vol. 128, no. 10, 2006

• P.B. Dervan, A.T. Poulin-Kerstien, E.J. Fechter, B.S. Edelson: Regulation of Gene Expression by Synthetic DNA-Binding Ligands.- J.B. Chaires: Structural Selectivity of Drug-Nucleic Acid Interactions Probed by Competition Dialysis.- B.A. Armitage: Cyanine Dye-DNA Interactions: Intercalation, Groove Binding and Aggregation.- L.D. Williams: Between Objectivity and Whim: Nucleic Acid Structural Biology.- N. Dias, H. Vezin, A. Lansiaux, C. Bailly: Topoisomerase Inhibitors of Marine Origin and Their Potential Use as Anticancer Agents.- C. Escudé, J.-S. Sun: DNA Major Groove Binders: Triple Helix-Forming Oligonucleotides, Triple Helix-Specific DNA Ligands and Cleaving Agents.- D.P. Arya: Aminoglycoside-Nucleic Acid Interactions: The Case for Neomycin.- D.S. Pilch, M. Kaul, C.M. Barbieri: Ribosomal RNA Recognition by Aminoglycoside Antibiotics.