From the reviews of the first edition: "Sanchez and colleagues have assembled a timely addition to the clinician's library. Their book is an up-to-date synthesis of the basic mechanisms of action of estrogen and SERMs with a comprehensive analysis of receptor-mediated and non-receptor mediated events in target tissue. The sections on new SERMs and the clinical endocrinology of SERMs are very useful and will remain so for some time. The choice of basic and clinical topics makes for interesting reading. ... Overall, the book is well written and easy to read." (V. Craig Jordan, The New England Journal of Medicine, January, 2007)

• Basic Area.- Molecular Mechanisms of Estrogen Action in Target Tissues.- Clinical Pharmacology of Selective Estrogen Receptor Modulators (SERMs).- Action of Selective Estrogen Receptor Modulators (SERMs) Through the Classical Mechanism of Estrogen Action.- Cellular and Molecular Basis for Acute Nongenomically Mediated Actions of SERMs.- The Hypothalamus-Pituitary-Ovarian Axis as a Model System for the Study of SERM Effects: An Overview of Experimental and Clinical Studies.- Pure Antiestrogens.- Clinical Area.- Physiological Regulation of Bone Metabolism and Estrogen Agonism.- The Role of SERMs in the Treatment of Osteoporosis.- Cardiovascular Disease and SERMs.- SERMs and the Breast.- Endometrial Effects of SERMs.- Benign Gynecological Diseases and SERMs.- Other Clinical Effects of SERMs.- The Role of SERMs in the Management of Postmenopausal Women.

From the reviews of the first edition: "Sanchez and colleagues have assembled a timely addition to the clinician's library. Their book is an up-to-date synthesis of the basic mechanisms of action of estrogen and SERMs with a comprehensive analysis of receptor-mediated and non-receptor mediated events in target tissue. The sections on new SERMs and the clinical endocrinology of SERMs are very useful and will remain so for some time. The choice of basic and clinical topics makes for interesting reading. ... Overall, the book is well written and easy to read." (V. Craig Jordan, The New England Journal of Medicine, January, 2007)

• Basic Area.- Molecular Mechanisms of Estrogen Action in Target Tissues.- Clinical Pharmacology of Selective Estrogen Receptor Modulators (SERMs).- Action of Selective Estrogen Receptor Modulators (SERMs) Through the Classical Mechanism of Estrogen Action.- Cellular and Molecular Basis for Acute Nongenomically Mediated Actions of SERMs.- The Hypothalamus-Pituitary-Ovarian Axis as a Model System for the Study of SERM Effects: An Overview of Experimental and Clinical Studies.- Pure Antiestrogens.- Clinical Area.- Physiological Regulation of Bone Metabolism and Estrogen Agonism.- The Role of SERMs in the Treatment of Osteoporosis.- Cardiovascular Disease and SERMs.- SERMs and the Breast.- Endometrial Effects of SERMs.- Benign Gynecological Diseases and SERMs.- Other Clinical Effects of SERMs.- The Role of SERMs in the Management of Postmenopausal Women.

From the reviews of the first edition: "Sanchez and colleagues have assembled a timely addition to the clinician's library. Their book is an up-to-date synthesis of the basic mechanisms of action of estrogen and SERMs with a comprehensive analysis of receptor-mediated and non-receptor mediated events in target tissue. The sections on new SERMs and the clinical endocrinology of SERMs are very useful and will remain so for some time. The choice of basic and clinical topics makes for interesting reading. ... Overall, the book is well written and easy to read." (V. Craig Jordan, The New England Journal of Medicine, January, 2007)

• Basic Area.- Molecular Mechanisms of Estrogen Action in Target Tissues.- Clinical Pharmacology of Selective Estrogen Receptor Modulators (SERMs).- Action of Selective Estrogen Receptor Modulators (SERMs) Through the Classical Mechanism of Estrogen Action.- Cellular and Molecular Basis for Acute Nongenomically Mediated Actions of SERMs.- The Hypothalamus-Pituitary-Ovarian Axis as a Model System for the Study of SERM Effects: An Overview of Experimental and Clinical Studies.- Pure Antiestrogens.- Clinical Area.- Physiological Regulation of Bone Metabolism and Estrogen Agonism.- The Role of SERMs in the Treatment of Osteoporosis.- Cardiovascular Disease and SERMs.- SERMs and the Breast.- Endometrial Effects of SERMs.- Benign Gynecological Diseases and SERMs.- Other Clinical Effects of SERMs.- The Role of SERMs in the Management of Postmenopausal Women.