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Beskrivning
Whereas a great deal has been learned during the past quarter century about the inflammatory processes associated with sepsis (and other related conditions, such as ischemia/reperfusion injury), our understanding is far less developed with respect to the pathophysiological events that lead to organ dysfunction under these conditions.
Mitochondrial Biology.- Cellular Responses to Hypoxia: Role of Oxidant Signal Transduction.- The Mitochondrial Permeability Transition: A ‘Pore ‘Way to Die.- Cytopathic Hypoxia in Circulatory Shock: The Role of Poly (ADP-Ribose) Synthetase Activation.- Derangements in Cellular Oxygen Metabolism.- Pharmacologic and Metabolic Mitochondrial Rescue.- Leukocytes and Cell Signaling Mechanisms in Inflammation.- Role of Leukocytes in Sepsis and Lung Injury.- Dysregulated Neutrophil Apoptosis in the Pathogenesis of Organ Injury in Critical Illness.- Does Apoptosis Play a Role in the Development of Sepsis-Induced Myocardial Dysfunction?.- The Intracellular Signaling Pathways of Inflammatory Stress.- Pro-Inflammatory Cytokines: Double-Edged Swords in the Pathogenesis of Bacterial Infection.- Organ-Organ Interactions in Multiple Organ Failure.- Microcirculatory Dysfunction.- Endothelial Cell Dysfunction and Abnormal Tissue Perfusion.- The Microcirculation in Sepsis.- Lung and Kidney.- Pulmonary Vascular Dysfunction.- Pulmonary Epithelial Injury: Clinical and Experimental Evidence for a Major Role in Acute Lung Injury and Multiple Organ Dysfunction.- Ischemia-Induced Derangements in the Actin Cytoskeleton: Mechanisms and Functional Significance.- Multiple Organ Failure and the Kidney.- Apoptosis in Renal Ischemia-Reperfusion Injury.- Gastrointestinal Tract.- Local Muscularis Inflammatory Mechanisms of Ileus.- Mechanisms Responsible for Intestinal Barrier Dysfunction in Critical Illness.- Liver Dysfunction: Nitric Oxide, Carbon Monoxide, and Reactive Oxygen Species.- Brain Injury.- Polyamine Oxidase and 3-Aminopropanal in the Pathogenesis of Cerebral Ischemia.- Key Mechanisms of Secondary Neuronal Damage After Brain Trauma.- Cerebral Ischemia: Pathophysiology andNeuroprotection.- Organ Dysfunction: Detection and Intervention.- Redistribution of Microvascular Oxygen Pressures in the Pig Intestine in Hemodilution and Sepsis.- Influence of Mechanical Ventilation on Organ Dysfunction.- Coagulation Abnormalities in Critical Illness.- Multiple Organ Failure: Clinical Syndrome.
