High Throughput Screening for Novel Anti-Inflammatories

Inbunden, Engelska, 2000

Del i serien Progress in Inflammation Research

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Beskrivning

Combinational chemistry in conjunction with High Thoroughput Screening (HTS) is revolutionizing the drug discovery process. The chapters in this book represent the state of the art regarding the integration of combinatorial chemisty and HTS in connection with anti-inflammatory targets. This text should set the stage for creative thinking among scientists of many disciplines for the accomplishment of our ultimate goals in treating inflammatory diseases.

Produktinformation

Utgivningsdatum:2000-05-01
Mått:155 x 235 x 21 mm
Vikt:576 g
Format:Inbunden
Språk:Engelska
Serie:Progress in Inflammation Research
Antal sidor:258
Upplaga:2000
Förlag:Birkhauser Verlag AG
ISBN:9783764359126

Utforska kategorier

Onkologi inom Medicin
Farmakologi inom Medicin

Innehållsförteckning

Contents. List of Contributors. Intoduction. Sharon M. Dankwardt: Solid phase synthesis: applications to combinatorial libraries. Mohamed A. Iqbal and Mark A. Ator: Proteaspme inhibitors. Tariq Ghayur, Sheryl J. Hays and Robert V. Talanian: Caspase-1 (ICE) and other caspases as drug discovery targets: opportunities and progress. William A. Metz and Norton P. Peet: Elastase inhibitors. M. Anthony Leesnitzer, D. Mark Bickett, Marcia L. Moss and J. David Becherer: A high-throughput assay for the TNF conerting enzyme. Kenneth D. Rice and William R. Moore: Tryptase inhibitors. Falguni Dasgupta: Selectin antagonists. Kerry W. Fowler and David T. Crowe: Cell adhesion integrins as pharmaceutical targets. Brion W. Murray, Yoshitaka Satoh and Bernd Stein: Inhibitors of the MAPK pathway. Mark J. Suto and Anthony M. Manning: Inhibition of NF-kB. Terry L. Bowlin, Stephen D. Yanofsky and Herman Schreuder: IL-1 antagonist discovery. Mark A. Giembycz: Phosphodiesterase inhibitors for respiratory disease. Subject index