Atul P Kulkarni MD (Anaesthesiology) FISCCM PGDHHM FICCM Professor and Head, Division of Critical Care Medicine, Department of Anaesthesiology, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, IndiaRoss Callum Freebairn MBChB Dip Obst FANZCA FRCPE FJFICMI(Hon) FCICMConsultant and Associate Dean, Intensive Care Medicine, Hawke’s Bay Hospital, Hastings New Zealand; School of Medicine, University of Otago Hastings, New ZealandSubhash P Acharya MD (Anaesthesiology) Fellowship in Adult Critical Care (FACC, University of Toronto) Professor and Head, Department of Critical Care Medicine, Maharjgunj Medical Campus, Institute of Medicine (IOM), Tribhuvan University, Kathmandu, Nepal

• SECTION 1: Airway Management — Current Controversies1. Can Sellick Maneuver Prevent Pulmonary Aspiration in the Critically Ill?2. Etomidate vs. Ketamine — What Should We Use for Intubation in ICUSECTION 2: Extracorporeal Therapies3. Plasmapheresis: Current Indications in the Critically Ill4. Are Super High-Flux Membrane Dialyzers the Future of RRT?5. What is New in Artificial Liver Support Systems?SECTION 3: Sepsis6. Back to the Genes: Does Genetic Polymorphism have a Role in Sepsis Management?7. Controversies in Surviving Sepsis Guidelines 20218. Are We Back to Square One? Early Fluids vs. Vasopreressors in Septic Shock9. Have We Achieved Balance in Fluid Therapy: Balanced Salt Solutions vs. Normal Saline?SECTION 4: Biomarkers10. Novel Biomarkers During Circulatory Shock11. Biomarkers in Acute Intoxications12. Do Biomarkers have a Role in Patients with Primary Brain Injury?13. Utility of MicroRNAs in the Critically Ill14. Neutrophil to Lymphocyte Ratio in Critically Ill: A Simple but Useful Marker?15. Do Vocal Biomarkers have a Future in Critical CareSECTION 5: COVID-19 Pandemic: Lessons Learnt16. Awake Prone Positioning in ARDS?17. Immunomodulators for COVID-19 Therapy18. Has Critical Care Telemedicine Come of Age During the Pandemic19. Post-COVID Conditions (PCCs) or Long COVID Syndrome20. Capacity Building During Large Scale Disasters21. Clearing the Air: Alternatives to Isolation RoomsSECTION 6: Mechanical Ventilation22. Revisiting Exogenous Surfactant Therapy in Acute Lung Injury and ARDS23. Mechanical Power24. Volumetric Capnography in 202225. Metabolic Alkalosis in Critical Care: A Classical and Physicochemical Approach26. Oxygen RevisitedSECTION 728. High-flow Nasal Cannula: Beyond a COVID-19 Therapy29. Cefiderocol30. Newer Fluoroquinolones: Levonadifloxacin, Delafloxacin and Lascufloxacin31. Newer Combinations of B-Lactam/B-Lactamase32. Newer Tetracyclines — Eravacycline and Omadacycline33. Plazomicin: A New Aminoglycoside34. Lefamulin: A Pleuromutilin Antibiotic35. Pretomanid for Antitubercular Therapy36. Contezolid Acefosamil: A New Oxazolidinone37. Solithromycin and Nafithromycin: The New Macrolides38. Benapenem and Sulopenem39. The Dsb (Disulfide bond)40. Antivirulence Strategies: The Future of Antibacterial Therapy41. Alternatives to Conventional Antibacterials: Use of Nanomaterials42. Newer Treatment Approach to Clostridioides Difficile – Fidaxomicin and Bezlotoxumab43. Recent Advances for Immunotherapies Against Infectious DiseaseSECTION 8: What's New Elsewhere?44. Risk Scoring Systems in Upper Gastrointestinal Bleed45. Has Hypotension Prediction Index Come of Age46. Postintensive Care Syndrome and Postintensive Care Syndrome-Family47. Closed-Loop Hemodynamic Resuscitation In Shock48. Is Electrical Impedance Tomography Finally Here to Stay49. Cardiac Output Measurement: Capnodynamic Method and Auto VTI Tool50. What’s New in Glucose Management Technologies for the Critically-ill51. Vitamins and Trace Element Supplementation for Critically Ill Patients in 2022Index