Safety and Efficacy of Non-Prescription (OTC) Analgesics and NSAIDs

Proceedings of the International Conference held at The South San Francisco Conference Center, San Francisco, CA, USA on Monday 17th March 1997

Häftad, Engelska, 2012

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Beskrivning

Concern in the UK about poisoning from paracetamol and the appreciable morbidity and mortality from aspirin was such that a major review was initiated in 1996 by the UK government's Medicines Control Agency (MCA).

Produktinformation

Utgivningsdatum:2012-10-04
Mått:155 x 235 x 10 mm
Vikt:260 g
Format:Häftad
Språk:Engelska
Antal sidor:150
Förlag:Springer
ISBN:9789401060448

Utforska kategorier

Farmakologi inom Medicin
Klinisk medicin och internmedicin inom Medicin

Innehållsförteckning

1. Current status of issues concerning the safety of over-the-counter analgesics and nonsteroidal anti-inflammatory drugs.- 2. Review of published clinical trial data on the adverse reactions from ibuprofen and paracetamol/acetaminophen at OTC dosages.- 3. Adverse drug reactions in the gastrointestinal system attributed to ibuprofen.- 4. The epidemiology of non-gastrointestinal adverse reactions from OTC analgesics.- 5. Renal safety of ibuprofen: pharmacokinetic aspects.- 6. Therapeutic considerations from pharmacokinetics and metabolism: ibuprofen and paracetamol.- 7. Acute human toxicity from NSAIDs and analgesics.- 8. Regulatory considerations concerning safety of OTC NSAIDs and analgesics.- 9. Evaluation of analgesic mechanisms and NSAIDs for acute pain using the oral surgery model.- 10. Multicentre study of the efficacy of ibuprofen compared with paracetamol in throat pain associated with tonsillitis.- 11. Ibuprofen plus caffeine in the treatment of migraine.- DEBATE — Safety and efficacy issues with OTC analgesics/NSAIDs Chair: KD Rainsford. Panel: Above contributors and WW Buchanan, BA Callingham, N Bellamy, DE Furst.