Photobiomodulation in Mucositis - Section 1

PHOTOBIOMODULATION IN MUCOSITISTowards Precision Mucosal PhotomedicineMucositis is no longer adequately understood as an unavoidable surface reaction to cancer treatment. It is a dynamic biological syndrome involving epithelial injury, mitochondrial dysfunction, inflammatory amplification, vascular and neural alterations, immune responses, microbial ecosystems and impaired tissue repair.This third volume of the PBM Clinical Series presents a comprehensive and clinically oriented vision of photobiomodulation in the prevention, treatment and rehabilitation of cancer therapy–induced mucosal injury.From the oral cavity to the broader mucosal continuum, it examines the biological foundations of mucositis, the current evidence for PBM, treatment timing, anatomical targeting, dosimetry, safety, adult and paediatric specificities, and the conditions required for responsible clinical implementation.Established indications are clearly distinguished from emerging applications. Particular attention is given to protocol quality, reproducibility, multidisciplinary care and the future integration of optical modelling, digital monitoring and artificial intelligence.More than a technical guide, this book proposes a new framework: precision mucosal photomedicine, in which the patient, the tissue, the biological phase, the optical pathway and the therapeutic objective are considered together.