Marianne Legato J – författare

The announcement that we had decoded the human genome in 2000 ushered in a new and unique era in biomedical research and clinical medicine. This Third Edition of Principles of Gender-Specific Medicine focuses, as in the past two editions, on the essentials of sexual dimorphism in human physiology and pathophysiology, but emphasizes the latest information about molecular biology and genomic science in a variety of disciplines. Thus, this edition is a departure from the previous two; the editor solicited individual manuscripts from innovative scientists in a variety of fields rather than the traditional arrangement of sections devoted to the various subspecialties of medicine edited by section chiefs. Wherever it was available, these authors incorporated the latest information about the impact of the genome and the elements that modify its expression on human physiology and illness. All chapters progress translationally from basic science to the clinical applications of gender-specific therapy and suggest the most important topics for future investigation.

This book is essential reading for all biomedical investigators and medical educators involved in gender-specific medicine. It will also be useful for primary care practitioners who need information about the importance of sex and gender in the prevention, diagnosis and treatment of illness.

Winner of the 2018 PROSE Award in Clinical Medicine from the Association of American Publishers!

2018 PROSE Awards - Winner, Award for Clinical Medicine: Association of American Publishers Outlines sex-specific differences in normal human function and explains the impact of age, hormones, and environment on the incidence and outcome of illness Reflects the latest information about the molecular basis of the sexual dimorphism in human physiology and the experience of disease Reviews the implications of our ever-improving ability to describe the genetic basis of vulnerability to disease and our capacity to alter the genome itself Illustrates the importance of new NIH guidelines that urge the inclusion of sex as a variable in research protocols

The International Society for Gender Medicine: History and Highlights is about a major step in the improvement of quality in medicine, namely the long overdue understanding that women are different from men in every system of the body and may require different approaches in diagnosis and treatment. This is not a textbook, nor is it a scientific publication. It is the story of the International Society for Gender Medicine (IGM) as soon through the eyes of 12 pioneers of Gender and Sex Specific Medicine (GSSM) from seven countries, five of whom were the founds of IGM in 2006. It describes the development of this new science in the respective countries and academic environments of the authors, their very personal experience while promoting, and implementing their vision of GSSM, their frustrations, successes, and achievements.

The field of gender-specific medicine examines how normal human biology and physiology differ between men and women and how the diagnosis and treatment of disease differs as a function of gender and sex. Among the areas of greatest difference are cardiovascular disease, mood disorders, the immune system, cancer, osteoporosis, diabetes, obesity, and infectious diseases.

This book is essential reading for all researchers, graduate students, practitioners, and anyone interested in this diverse and thriving field. From the early beginning, to the recent NIH mandate that females be included in pre-clinical as well as clinical research and that research results be reported by sex, the quick read will broaden your understanding of the history of the field and highlight where the future is headed.

Illustrates how major universities and organizations around the world concentrated first on the unexplored world of women's biology and then progressively adopted the larger view of the importance of investigating and comparing both sexes through all levels of biomedical research Notes the recent NIH statement that funding would depend on inclusion of two sexes in scientific protocols wherever possible as an important affirmation of the legitimacy of gender specific science Addresses challenges for the future: how to incorporate both sexes in investigative protocols in a scientifically valid way, and whether or not the cost of including two sexes in protocols will be prohibitively expensive Dispels the idea that gender-specific medicine is women's medicine and how changing the name of most of the organizations currently advocating and developing gender specific medicine to include men and women (rather than just women) in their group name would help dispel this notion

The Plasticity of Sex: The Molecular Biology and Clinical Features of Genomic Sex, Gender Identity and Sexual Behavior provides a comprehensive view on the development of human sexuality. As there has been a crescendo of interest over the past several decades about the nature and diversity of human sexuality, this reference brings the evidence-based research into one place. The emergence of issues surrounding gender identity, genital ambivalence and the transition from one sex to another is striking, with the public and treating physicians alike clamoring for an evidence-based, comprehensive treatment of human sexuality and all its variations.

This is a must-have reference for biomedical researchers in endocrinology, neuroscience, development biology, medical students, residents, and practicing physicians from all medical areas.

Winner of the 2021 PROSE Award in Biomedicine from the Association of American Publishers!

2021 PROSE Awards - Winner: Category: Biomedicine: Association of American Publishers Discusses the role of biology in gender identity from research in genetics, endocrinology and neuroscience Addresses important health disparities and how to address them when treating the transgender patient Reviews evidence-based information on the biological basis and impact of environmental and hormonal factors at different life stages Outlines schema for treating variations in the sexuality and sexual function of the individual patient

Sex, Gender, and Epigenetics: From Molecule to Bedside explores our expanding knowledge of the science of epigenetics in which gene expression is modified as a consequence of small chemical additions to various components of the genome. The book provides an overview of the field, describing the epigenetic phenomena that unite biological sex and environmental experience to create the unique phenome of each individual. The book also analyzes the impact of ancestors' environmental experience on subsequent generations through the sex-specific transmission of environmentally induced epigenetic modifications.

Here, international leaders in the field discuss both sex-specific normal physiology and the experience of disease, with chapters dedicated to fetal programming, the microbiome, cancer, bipolar disorder and schizophrenia, embryogenesis, and oocyte aging, among other topics.

Examines the impact of biological sex and gender on gene expression through epigenetic mechanisms, and its relationship to human biology and disease Presents the current state of our understanding of how environmental experience is translated to future generations in a sex specific manner Features chapter contributions from international leaders in the field

Awarded with the 2018 Prose Award in Clinical Medicine, the third edition of Principles of Gender-Specific Medicine explored and described exciting new areas in biomedicine that integrated technology into the treatment of disease and the augmentation of human function. Novel topics such as the sex-specific aspects of space medicine, the development and the use of genderized robots and a discussion of cyborgs were included in the third edition, providing a preview of the expanding world of sex-specific physiology and therapeutics. This Fourth Edition is a continuation of the mission to trace the relevance of biological sex to normal function and to the experience of disease in humans.We are now twenty years into the postgenomic era. The investigation of how the genome produces the phenome has led to fascinating insights as well as yet unanswered questions. Principles of Gender-Specific Medicine, Fourth Edition, has a central theme: discuss advances in understanding the role of epigenetics in regulating gene expression in a dynamic, sex-specific way during human life. It explores the protean role of epigenetics in human physiology, the relevance of environmental experience to human function, the therapeutic promise of cutting-edge methodologies like gene manipulation, the preparation of humans for space travel, the use of artificial intelligence in detection and therapeutic decisions concerning disease states, the possibilities for technological support of not only compromised individuals but of the augmentation of human function, and an analysis of the benefits, limitations and issues that surround our current expectations of personalized medicine. Covers the most important developments in biomedical research in the past decade, with a thoughtful analysis of how they impact patient care Discusses the feasibility and usefulness of personalized medicine, the limits and promise of genetic editing, the basis for variation in sexual identity and how artificial intelligence and technology will affect basic human function as well as correcting disability Promotes and facilitates discussions about the ethics and governance issues that surround much of what science is now able to do at the most basic levels of human's physiology