Simone Ferrero – författare

Endometriosis affects millions of women worldwide, yet it remains frequently misdiagnosed, delaying care and increasing the risk of serious complications. Adding to the diagnostic complexity is the factor of extra-pelvic involvement, which most gynecologists have not been trained to recognize. Diagnosis of Endometriosis: A Practical Manual meets a critical need for today’s clinicians by providing clear guidance on the imaging techniques essential for diagnosing the full spectrum of endometriosis, from ovarian and deep pelvic disease to intestinal and urinary tract involvement.

Endometrial cancer is the most common gynecological cancer and the sixth cause of cancer in developed countries. The findings that EC is a heterogeneous group of tumors with distinct risk factors and histopathological features, together with our improved understanding of its molecular mechanism has paved the way to the investigation of new surgical and medical therapies. The aim of this book is to give a complete overview on risk factors, pre-operative methods and management of endometrial cancer. The authors hope that this book will be a useful tool for any health provider involved in gynecological cancer care.

Uterine myomas are the most common form of benign uterine tumors, occurring in 50–60% of women. Clinically, they are mostly asymptomatic, often incidentally found on pelvic examination or by routine gynecological ultrasonographic evaluation; otherwise, in 30–40% of cases, they cause a large variety of symptoms, depending on their location and size. Currently, the therapeutic options for myomas are medical, radiological, and surgical. The aim of this book is to summarize the evidence regarding epidemiology, pathogenesis, clinical presentation, diagnosis and management of uterine myomas.

Endometriosis is a chronic benign estrogen-dependent disease which is characterized by the presence of endometriotic glands and stroma outside the uterine cavity. It affects women during reproductive age, but it may also be diagnosed in menopausal women. Endometriosis can be asymptomatic; but most frequently it can be responsible for pain symptoms and/or infertility, severely impacting women’ quality of life. Overall, clinical presentation depends on the location of endometriotic lesions: intestinal symptoms can occur in case of bowel nodules whereas urinary symptoms can occur in case of urinary tract endometriosis. At the moment, the exact prevalence of endometriosis is unknown because its definitive diagnosis requires surgery and histological evaluation. It has been estimated that this benign chronic disease affects at least 3.6% of reproductive age women; however, its prevalence could significantly increase considering women suffering from dysmenorrhea, chronic pelvic pain and/or infertility. The etiology of endometriosis is unclear: various factors, such as multiple abnormalities of the immune system, genetic factors and environmental factors may influence women’ susceptibility to develop this chronic disease. Although the gold standard for the diagnosis of endometriosis is the pathological evaluation of surgical biopsies or specimens, today transvaginal ultrasonography is largely employed to reliably identify the presence of deep infiltrating endometriosis or ovarian endometriomas. The aim of the surgery for endometriosis is to restore the normal anatomy by removing endometriotic lesions and by performing adequate removal of abdominal adhesions. However, surgery, in case of deep infiltrating implants, can be rather challenging for gynecologists due to the complexity of pelvic adhesions involving several structures and it may be characterized by rare but not negligible urological, intestinal, neurological and vascular complications. Furthermore, pain may recur after conservative surgery for endometriosis. Although surgery is obviously required in cases of ureteral stenosis, bowel occlusion or ovarian cysts with doubtful characteristics of malignancy, medical therapy, and, particularly, hormonal therapies, are the initial therapeutic approach today for most patients with endometriosis-related pain. Long-term medical therapy for endometriosis aims to minimize the production and action of estradiol, inhibiting the production of cyclic hormones from the ovaries. Numerous medical options (such as estroprogestins, progestins, gonadotropin- releasing hormones analogs and antagonists) are available for treating women with endometriosis: the choice of the most suitable compound is based on several factors, such as intensity of pain, age, desire to conceive, costs, route of administration and impact of the endometriosis on work capacity, sexual function and quality of life of each woman. Currently, research is focused on finding new innovative targets to treat this benign chronic disease; in fact, it is well known that development, maintenance and progression of endometriosis depend on a variety of aberrant mechanisms including cell proliferation, immune function, apoptosis, invasion capacity and angiogenesis. The aim of this book is to give an accurate overview on pathogenesis, diagnosis and therapy of endometriosis.

This book exclusively focuses on the practical aspects of diagnosing and managing bowel endometriosis, and highlights the importance of pursuing a multidisciplinary approach.Collecting chapters written by international experts in the field, the book is divided into two parts: the first presents all imaging techniques that are currently available and useful in diagnosing bowel endometriosis, while the second covers all available surgical techniques for treating this disorder, including the modern and lesser-invasive Nerve-Sparing radical approaches.Featuring a wealth of figures, sketches and videos, the book offers an essential guide for specialists, resident and subspecialty trainees in the fields of gynecology, colorectal surgery, radiology and gastroenterology.

This book exclusively focuses on the practical aspects of diagnosing and managing bowel endometriosis, and highlights the importance of pursuing a multidisciplinary approach.

Collecting chapters written by international experts in the field, the book is divided into two parts: the first presents all imaging techniques that are currently available and useful in diagnosing bowel endometriosis, while the second covers all available surgical techniques for treating this disorder, including the modern and lesser-invasive Nerve-Sparing radical approaches.

Featuring a wealth of figures, sketches and videos, the book offers an essential guide for specialists, resident and subspecialty trainees in the fields of gynecology, colorectal surgery, radiology and gastroenterology.

This book exclusively focuses on the practical aspects of diagnosing and managing bowel endometriosis, and highlights the importance of pursuing a multidisciplinary approach.Collecting chapters written by international experts in the field, the book is divided into two parts: the first presents all imaging techniques that are currently available and useful in diagnosing bowel endometriosis, while the second covers all available surgical techniques for treating this disorder, including the modern and lesser-invasive Nerve-Sparing radical approaches.Featuring a wealth of figures, sketches and videos, the book offers an essential guide for specialists, resident and subspecialty trainees in the fields of gynecology, colorectal surgery, radiology and gastroenterology.

This unique book examines in detail the pathogenesis and management of endometriosis-related infertility.Witten by international experts in the field, it focuses on the management of infertility in women with different forms of endometriosis (ovarian endometrioma, superficial endometriosis, deep endometriosis). It also discusses the impact of endometriosis on endometrial receptivity, oocytes and implantation, addressing both molecular and clinical aspects.This book is intended for physicians treating patients with endometriosis-related infertility, physicians and biologists working at infertility centers, trainees in gynecology, and subspecialty fellows in reproductive medicine.

This unique book examines in detail the pathogenesis and management of endometriosis-related infertility.

Witten by international experts in the field, it focuses on the management of infertility in women with different forms of endometriosis (ovarian endometrioma, superficial endometriosis, deep endometriosis). It also discusses the impact of endometriosis on endometrial receptivity, oocytes and implantation, addressing both molecular and clinical aspects.

 This book is intended for physicians treating patients with endometriosis-related infertility, physicians and biologists working at infertility centers, trainees in gynecology, and subspecialty fellows in reproductive medicine.