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Del 11 - Alkaloids: Chemical and Biological Perspectives

Alkaloids: Chemical and Biological Perspectives

AvWilliam Ed. S.W. Ed. Pelletier,William Ed S. W. Ed Pelletierm. fl.

Inbunden, Engelska, 1996

2 559 kr

Skickas inom 5-8 vardagar

Volume 11 of this series presents five timely reviews on current research on alkaloids. Chapter 1 by Paul L. Schiff, Jr. is a monumental survey of research that has been carried out over the past decade on the Thalictrum alkaloids. Forty-six new alkaloids are described from fifteen species of the genus Thalictrum, as well as 116 alkaloids of known structure from thirty-six species and subspecies of the genus. The chapter includes discussions of isolation and structure elucidation, analysis, biosynthesis, cell culture, and pharmacology. Also featured are inclusive compilations of botanical sources, alkaloids by alkaloid types, and calculated molecular weights of the Thalictrum alkaloids.

Chapter 2 by Giovanni Appendino provides a fascinating treatment of Taxine, a collective name referring to a mixture of diterpenoid alkaloids from the yew tree (genus: Taxus). Taxine is responsible for the toxic properties of the yew tree that has been documented in historical and fictional literature, from Julius Caesar to Shakespeare, and from Agatha Christie to T.S. Eliot. The chapter treats the history, isolation techniques, structure elucidation, chemistry, and pharmacology of Taxine.

Chapter 3 by Mary D. Menachery surveys the alkaloids of South American Menispermaceae (moonseed family). Many different structural types are included in this family. The alkaloid-bearing plants are woody-vines, shrubs, or small trees. Several of these species possess potent curare activity. The chemistry as well as pharmacology of these alkaloids is summarized.

Chapter 4 by Russell J. Molyneux, Robert J. Nash, and Naoki Asano treats the chemistry and biological activity of the calystegines and related nortropane alkaloids. These polyhydroxylated bicyclic alkaloids represent another class of compounds that inhibit glycosidases, producing profound effects in biological systems by disrupting the essential cellular function of glycoprotein processing.

Chapter 5, a related chapter by Robert J. Nash, Naoki Asano, and Alison A. Watson, reviews polyhydroxylated alkaloids that inhibit glycosidases. Topics covered include distribution, ecological significance and toxicity, isolation, synthesis, and biosynthesis.

Del 12 - Alkaloids: Chemical and Biological Perspectives

Alkaloids: Chemical and Biological Perspectives

AvWilliam Ed. S.W. Ed. Pelletier,William Ed S. W. Ed Pelletierm. fl.

Inbunden, Engelska, 1998

2 559 kr

Skickas inom 5-8 vardagar

Acronycine, a potent antitumor agent, was discovered in the bark of the small Australian Rutaceous tree, Acronychia baueri Schott. This new work presents a comprehensive survey of the isolation, structure determination, methods of synthesis, and the biological properties of acronycine, as well as an account of natural and synthetic analogues of acronycine, and their biological properties.Solanum alkaloids were reviewed in 1990 and this book surveys the new developments (isolation procedures, structural elucidation methods) and critically updates earlier reviews. In addition it presents the interesting chemistry and synthesis of cyclopeptide alkaloids. These cyclopeptide alkaloids have been isolated from ascidians, sea hares, and cyanobacteria. Also included are reviews of the use of the functionalized lactam, pyroglutamic acid, as a chiral template for the synthesis of alkaloids. The second review examines the on-line coupling of capillary electrophoresis (CE) and mass spectrometry (MS) for the analysis of alkaloid mixtures. Finally a review of oxygenated analogs of the alkaloid Marcfortine for their potent antiparasitic activity is included at the end of this work. Each chapter in this volume has been reviewed by at least one expert in the field. Indexes for both subjects and organisms are provided.

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William Ed. S.W. Ed. Pelletier - Böcker

Alkaloids: Chemical and Biological Perspectives

Alkaloids: Chemical and Biological Perspectives

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