Philip Mayles, formerly of the Clatterbridge Centre for Oncology, UK.Alan Nahum, formerly of the Clatterbridge Centre for Oncology, UK.Jean Claude Rosenwald, formerly at Institute Curie, Paris, France.

Praise for the first edition:"… Due to the broad range of topics covered and the clear, concise explanations, this text would be ideal for anyone wishing to study or refresh their knowledge of any central area of radiotherapy physics. IPEM Part 1 trainees in the UK (and any other trainee following a similar training programme elsewhere) in particular should take note … . Part 2 trainees will also benefit, especially in exploring the excellent source of referenced material. In comparison to other reference texts, the Handbook of Radiotherapy Physics is clear and also filled with many knowledgeable and useful observations and notes. … It is an excellent reference text and sits nicely on the shelf alongside your old copy of Williams and Thwaites."—SCOPE, December 2009"… comprehensive reference … With contributions from renowned specialists, this book provides essential theoretical and practical knowledge to deliver safe and effective radiotherapy." —Anticancer Research, 2009, Vol. 29"The editors have managed with great success to assemble the information submitted by the contributing authors and put it in a format that is concise, easy to read, and rich in content … it can serve as an excellent reference manual and resource." —Niko Papanikolaou, University of Texas Health Sciences Center, Medical Physics, September 2008, Vol. 35, No. 9Praise for the second edition:"This is the 2nd edition of the Handbook of Radiotherapy published in 2007. The book is organized into 11 parts, each dealing with a self-contained subject area including but not limited to Fundamentals, Radiobiology, Equipment, Dose Measurement, Treatment Planning, Quality Assurance, Therapy with Unsealed Sources, and Radiation Protection. An additional part has been included at the end of Vol.2, which provides tables of physical constants and radiation interaction data. This textbook is meant to be a comprehensive handbook practical radiotherapy knowledge for both medical that covers theoretical and physics trainees and practicing medical physicists. It provides a good overview of theoretical knowledge along with a practical description of concepts. In keeping with the original intent of the first edition, this book is intended primarily as course book for physicists in training but could also act as a reference book for practicing radiation physicists. It is a useful supplement to classic radiotherapy textbooks; concepts are introduced very well and extensive references are provided if the readers require a more in-depth review. The editors and authors have wide ranging medical physics experience across the UK, Europe, and U.S.The text is very comprehensive, with sections covering classic topics in the field along with modern topics such as knowledge-based planning, artificial intelligence, and MR-guided linear accelerators. I especially appreciated the quality assurance (QA) part, which included chapters ranging from QA of treatment planning and treatment delivery to data communication with DICOM. Overall, this is a well-written handbook. Due to the extensive changes in the field of medical physics since 2007, this is a necessary and thoughtful update. The editors did a great job of assembling a huge amount of information. Given the breadth and scope of this text, along with the extensive bibliography, this handbook would be a great resource, especially for trainees and early career physicists."—Katelyn Hasse (University of California, San Francisco), in Medical Physics, The International Journal of Medical Physics Research and Practice (July 2022)The treatment of cancer by ionizing radiation – radiotherapy (RT) – has undergone continuous development since the early years of the twentieth century. This book, in two volumes (each containing the contents and index of the complete work) represents a comprehensive updating of the first edition (published in 2007). High-quality RT outcomes depend on close collaboration by radiation oncologists, therapy radiographers (aka radiation technologists), dosimetrists, physicists and, not infrequently, RT equipment engineers. Whilst this book is primarily written by physicists for physicists, some of the material should be useful, even essential, to anyone whose work involves radiotherapy, including those who train such professionals.The book is organised into eleven "parts", covering different topics, plus Part L – data tables – now including the stopping power and ranges of protons (up to 300 MeV kinetic energy) in elements, compounds and mixtures of medical interest. A total of 62 scientists – eminent specialists (from Europe, North America and elsewhere) – have produced the 61 chapters, including colleagues who did not contribute to the first edition. Parts A through C cover the fundamentals of the relevant physics, radiobiology and technology. Parts D through H give the practical information necessary for the support of external-beam RT: dose measurements, clinical beam properties, the computation of dose distributions in patient anatomy, treatment (aka dose) planning and quality assurance. RT delivered with radionuclides is described in Part I (brachytherapy) and Part J (unsealed sources aka "molecular radiotherapy"). Part K covers the radiation protection framework, with an emphasis on the legislation in the UK. We editors hope that our readers will learn as much from reading the book as we have by bringing the 2007 edition up to date. May they be inspired to continue the development of the scientific and technical basis of radiotherapy for the benefit of cancer patients worldwide. –Scope magazine, (December 2022)

• Part A FundamentalsChapter 1 Structure of MatterJean ChavaudraChapter 2 RadioactivityJean ChavaudraChapter 3 Interactions of Charged Particles with MatterAlan NahumChapter 4 Interactions of Uncharged Particles with MatterDavid R. Dance, Jean-Claude Rosenwald, and Gudrun Alm CarlssonChapter 5 Principles and Basic Concepts in Radiation DosimetryAlan NahumReferencesPart B RadiobiologyChapter 6 Radiobiology of TumoursGordon Steel, Catharine West, and Alan NahumChapter 7 Radiobiology of Normal TissuesGordon Steel and Catharine WestChapter 8 Dose Fractionation in RadiotherapyGordon Steel, Catharine West, and Alan NahumReferencesPart C EquipmentChapter 9 Equipment for Patient Data AcquisitionJean-Claude RosenwaldChapter 10 Kilovoltage X-Ray UnitsTony Greener and David EatonChapter 11 Traditional Linear AcceleratorsHamish PorterChapter 12 Machines with Radionuclide SourcesJohn Saunders, Lee Walton, and Katharine HuntChapter 13 In-Room Imaging Devices Used for TreatmentCephas MubataChapter 14 CyberKnife, TomoTherapy and MR-Guided Linear AcceleratorsThomas Lacornerie, Albert Lisbona, and Andrew W. BeavisChapter 15 Accelerators for Protons and Other Heavy Charged ParticlesAlejandro Mazal and Annalisa PatriarcaReferencesPart D Dose MeasurementChapter 16 Ionisation ChambersBryan Muir and Alan NahumChapter 17 Solid-State Dose Measuring DevicesGinette MarinelloChapter 18 Two-dimensional and Three-dimensional DosimetryMark Oldham, Devon Godfrey, Titania Juang, and Andrew ThomasChapter 19 Reference Dose Determination under Reference ConditionsAlan Nahum and Bryan MuirChapter 20 Relative Dose MeasurementsIvan RosenbergReferencesPart E Clinical BeamsChapter 21 The Framework Relating Measurements to Calculation of Delivered DosePhilip MaylesChapter 22 Kilovoltage X-Ray BeamsPhilip MaylesChapter 23 High-Energy Photon BeamsPhilip MaylesChapter 24 Electron BeamsDavid Thwaites and Alan McKenzieChapter 25 Proton and Other Heavy Charged-Particle BeamsAlejandro Mazal and Ludovic de MarziReferencesPart F Patient Dose Calculation MethodsChapter 26 Parameters and Methodology for Point Dose Calculation in Photon BeamsIvan Rosenberg and Jean-Claude RosenwaldChapter 27 Framework for Computation of Patient Dose DistributionJean-Claude RosenwaldChapter 28 Photon Beams: Broad-Beam and Superposition MethodsJean-Claude Rosenwald, Ivan Rosenberg, and Glyn ShentallChapter 29 Charged-Particle Beams: The Pencil-Beam ApproachAlan NahumChapter 30 Monte-Carlo and Grid-Based-Deterministic Models for Patient Dose ComputationAlan Nahum and Jean-Claude RosenwaldReferencesVOLUME 2Preface to the Second EditionThe EditorsList of Contributors to the Second EditionPart G Treatment PlanningChapter 31 Target and Organ at Risk Definition – Dose Prescription and ReportingAnthony Neal and Jean-Claude RosenwaldChapter 32 Computed Tomography Imaging in RadiotherapyNathalie Fournier-BidozChapter 33 Magnetic Resonance Imaging in Treatment PlanningVincent S. KhooChapter 34 Radionuclide Imaging in Treatment PlanningYolande PetegniefChapter 35 Image Registration, Segmentation and Virtual SimulationVibeke Nordmark Hansen and Jean-Claude RosenwaldChapter 36 Photon-Beam Forward Planning TechniquesPeter Childs and Christine LordChapter 37 Intensity-Modulated Radiation Therapy and Inverse PlanningHelen Mayles, John Fenwick, and Steve WebbChapter 38 Electron-Beam Treatment Planning TechniquesAlan McKenzie and David Thwaites (Updated by Philip Mayles)Chapter 39 Proton-Beam Treatment Planning TechniquesFrancesca Albertini, Alessandra Bolsi, and Juliane DaartzChapter 40 Intracranial and Body Stereotactic RadiotherapyJim Warrington and Vivian CosgroveChapter 41 Total Body IrradiationPhilip MaylesChapter 42 Total Skin Electron IrradiationDavid Thwaites and Alan McKenzie (Updated by Philip Mayles)Chapter 43 Dose Evaluation of Treatment PlansMargaret Bidmead and Jean-Claude RosenwaldChapter 44 Radiobiological Evaluation and Optimisation of Treatment PlansAlan Nahum and Eva OnjukkaReferencesPart H Quality AssuranceChapter 45 Quality and Safety ManagementPhilip Mayles, David Thwaites, and Jean-Claude RosenwaldChapter 46 Quality Control of High-Energy External BeamsEdwin Aird, Philip Mayles, and Cephas MubataChapter 47 Quality Assurance of the Treatment Planning ProcessJean-Claude RosenwaldChapter 48 Quality Assurance of Treatment DeliveryMargaret Bidmead, Nathalie Fournier-Bidoz, Ginette Marinello, Jean-Claude Rosenwald, Helen MaylesChapter 49 Data Communication with DICOMJohn Sage, John N.H. Brunt and Philip MaylesReferencesPart I BrachytherapyChapter 50 Brachytherapy Clinical IntroductionPeter HoskinChapter 51 Calibration and Quality Assurance of SourcesColin H. Jones and Chris D. LeeChapter 52 Afterloading Equipment for BrachytherapyMargaret BidmeadChapter 53 Dose Calculation for Brachytherapy SourcesPhilip MaylesChapter 54 Brachytherapy Treatment PlanningMargaret Bidmead, Dorothy Ingham, Peter Bownes and Chris D. LeeChapter 55 Radiobiology of BrachytherapyRoger DaleReferencesPart J Therapy with Unsealed SourcesChapter 56 Radionuclide Selection for Targeted Molecular RadiotherapyCaroline StokkeChapter 57 Targeted Molecular Radiotherapy – Clinical Considerations and DosimetryGlenn Flux and Alan NahumReferencesPart K Radiation Protection in RadiotherapyChapter 58 Theoretical Background to Radiation ProtectionMike Rosenbloom and Philip MaylesChapter 59 Radiation Protection Regulation Mike Rosenbloom and Philip MaylesChapter 60 Radiation Protection of Staff and the PublicMike Rosenbloom and Philip MaylesChapter 61 Radiation Protection of the PatientPhilip Mayles and Uwe SchneiderAppendix K1: A Regulatory Framework (UK examplePhilip MaylesAppendix K2: Example Wall Thickness CalculationsPhilip MaylesAppendix K3: Example Local Rules for Handling Radioactive SourcesMike Rosenbloom and Philip MaylesReferencesPart L Data TablesTables L1 Physical Constants and Useful DataTables L2 Charged Particle Stopping Power and RangeTables L3 Photon Interaction CoefficientsTables L4 Typical Megavoltage Photon Beam Data.

Philip Mayles, formerly of the Clatterbridge Centre for Oncology, UK.Alan Nahum, formerly of the Clatterbridge Centre for Oncology, UK.Jean Claude Rosenwald, formerly at Institute Curie, Paris, France.

Praise for the first edition:"… Due to the broad range of topics covered and the clear, concise explanations, this text would be ideal for anyone wishing to study or refresh their knowledge of any central area of radiotherapy physics. IPEM Part 1 trainees in the UK (and any other trainee following a similar training programme elsewhere) in particular should take note … . Part 2 trainees will also benefit, especially in exploring the excellent source of referenced material. In comparison to other reference texts, the Handbook of Radiotherapy Physics is clear and also filled with many knowledgeable and useful observations and notes. … It is an excellent reference text and sits nicely on the shelf alongside your old copy of Williams and Thwaites."—SCOPE, December 2009"… comprehensive reference … With contributions from renowned specialists, this book provides essential theoretical and practical knowledge to deliver safe and effective radiotherapy." —Anticancer Research, 2009, Vol. 29"The editors have managed with great success to assemble the information submitted by the contributing authors and put it in a format that is concise, easy to read, and rich in content … it can serve as an excellent reference manual and resource." —Niko Papanikolaou, University of Texas Health Sciences Center, Medical Physics, September 2008, Vol. 35, No. 9Praise for the second edition:"This is the 2nd edition of the Handbook of Radiotherapy published in 2007. The book is organized into 11 parts, each dealing with a self-contained subject area including but not limited to Fundamentals, Radiobiology, Equipment, Dose Measurement, Treatment Planning, Quality Assurance, Therapy with Unsealed Sources, and Radiation Protection. An additional part has been included at the end of Vol.2, which provides tables of physical constants and radiation interaction data. This textbook is meant to be a comprehensive handbook practical radiotherapy knowledge for both medical that covers theoretical and physics trainees and practicing medical physicists. It provides a good overview of theoretical knowledge along with a practical description of concepts. In keeping with the original intent of the first edition, this book is intended primarily as course book for physicists in training but could also act as a reference book for practicing radiation physicists. It is a useful supplement to classic radiotherapy textbooks; concepts are introduced very well and extensive references are provided if the readers require a more in-depth review. The editors and authors have wide ranging medical physics experience across the UK, Europe, and U.S.The text is very comprehensive, with sections covering classic topics in the field along with modern topics such as knowledge-based planning, artificial intelligence, and MR-guided linear accelerators. I especially appreciated the quality assurance (QA) part, which included chapters ranging from QA of treatment planning and treatment delivery to data communication with DICOM. Overall, this is a well-written handbook. Due to the extensive changes in the field of medical physics since 2007, this is a necessary and thoughtful update. The editors did a great job of assembling a huge amount of information. Given the breadth and scope of this text, along with the extensive bibliography, this handbook would be a great resource, especially for trainees and early career physicists."—Katelyn Hasse (University of California, San Francisco), in Medical Physics, The International Journal of Medical Physics Research and Practice (July 2022)The treatment of cancer by ionizing radiation – radiotherapy (RT) – has undergone continuous development since the early years of the twentieth century. This book, in two volumes (each containing the contents and index of the complete work) represents a comprehensive updating of the first edition (published in 2007). High-quality RT outcomes depend on close collaboration by radiation oncologists, therapy radiographers (aka radiation technologists), dosimetrists, physicists and, not infrequently, RT equipment engineers. Whilst this book is primarily written by physicists for physicists, some of the material should be useful, even essential, to anyone whose work involves radiotherapy, including those who train such professionals.The book is organised into eleven "parts", covering different topics, plus Part L – data tables – now including the stopping power and ranges of protons (up to 300 MeV kinetic energy) in elements, compounds and mixtures of medical interest. A total of 62 scientists – eminent specialists (from Europe, North America and elsewhere) – have produced the 61 chapters, including colleagues who did not contribute to the first edition. Parts A through C cover the fundamentals of the relevant physics, radiobiology and technology. Parts D through H give the practical information necessary for the support of external-beam RT: dose measurements, clinical beam properties, the computation of dose distributions in patient anatomy, treatment (aka dose) planning and quality assurance. RT delivered with radionuclides is described in Part I (brachytherapy) and Part J (unsealed sources aka "molecular radiotherapy"). Part K covers the radiation protection framework, with an emphasis on the legislation in the UK. We editors hope that our readers will learn as much from reading the book as we have by bringing the 2007 edition up to date. May they be inspired to continue the development of the scientific and technical basis of radiotherapy for the benefit of cancer patients worldwide. –Scope magazine, (December 2022)

• Part A FundamentalsChapter 1 Structure of MatterJean ChavaudraChapter 2 RadioactivityJean ChavaudraChapter 3 Interactions of Charged Particles with MatterAlan NahumChapter 4 Interactions of Uncharged Particles with MatterDavid R. Dance, Jean-Claude Rosenwald, and Gudrun Alm CarlssonChapter 5 Principles and Basic Concepts in Radiation DosimetryAlan NahumReferencesPart B RadiobiologyChapter 6 Radiobiology of TumoursGordon Steel, Catharine West, and Alan NahumChapter 7 Radiobiology of Normal TissuesGordon Steel and Catharine WestChapter 8 Dose Fractionation in RadiotherapyGordon Steel, Catharine West, and Alan NahumReferencesPart C EquipmentChapter 9 Equipment for Patient Data AcquisitionJean-Claude RosenwaldChapter 10 Kilovoltage X-Ray UnitsTony Greener and David EatonChapter 11 Traditional Linear AcceleratorsHamish PorterChapter 12 Machines with Radionuclide SourcesJohn Saunders, Lee Walton, and Katharine HuntChapter 13 In-Room Imaging Devices Used for TreatmentCephas MubataChapter 14 CyberKnife, TomoTherapy and MR-Guided Linear AcceleratorsThomas Lacornerie, Albert Lisbona, and Andrew W. BeavisChapter 15 Accelerators for Protons and Other Heavy Charged ParticlesAlejandro Mazal and Annalisa PatriarcaReferencesPart D Dose MeasurementChapter 16 Ionisation ChambersBryan Muir and Alan NahumChapter 17 Solid-State Dose Measuring DevicesGinette MarinelloChapter 18 Two-dimensional and Three-dimensional DosimetryMark Oldham, Devon Godfrey, Titania Juang, and Andrew ThomasChapter 19 Reference Dose Determination under Reference ConditionsAlan Nahum and Bryan MuirChapter 20 Relative Dose MeasurementsIvan RosenbergReferencesPart E Clinical BeamsChapter 21 The Framework Relating Measurements to Calculation of Delivered DosePhilip MaylesChapter 22 Kilovoltage X-Ray BeamsPhilip MaylesChapter 23 High-Energy Photon BeamsPhilip MaylesChapter 24 Electron BeamsDavid Thwaites and Alan McKenzieChapter 25 Proton and Other Heavy Charged-Particle BeamsAlejandro Mazal and Ludovic de MarziReferencesPart F Patient Dose Calculation MethodsChapter 26 Parameters and Methodology for Point Dose Calculation in Photon BeamsIvan Rosenberg and Jean-Claude RosenwaldChapter 27 Framework for Computation of Patient Dose DistributionJean-Claude RosenwaldChapter 28 Photon Beams: Broad-Beam and Superposition MethodsJean-Claude Rosenwald, Ivan Rosenberg, and Glyn ShentallChapter 29 Charged-Particle Beams: The Pencil-Beam ApproachAlan NahumChapter 30 Monte-Carlo and Grid-Based-Deterministic Models for Patient Dose ComputationAlan Nahum and Jean-Claude RosenwaldReferencesVOLUME 2Preface to the Second EditionThe EditorsList of Contributors to the Second EditionPart G Treatment PlanningChapter 31 Target and Organ at Risk Definition – Dose Prescription and ReportingAnthony Neal and Jean-Claude RosenwaldChapter 32 Computed Tomography Imaging in RadiotherapyNathalie Fournier-BidozChapter 33 Magnetic Resonance Imaging in Treatment PlanningVincent S. KhooChapter 34 Radionuclide Imaging in Treatment PlanningYolande PetegniefChapter 35 Image Registration, Segmentation and Virtual SimulationVibeke Nordmark Hansen and Jean-Claude RosenwaldChapter 36 Photon-Beam Forward Planning TechniquesPeter Childs and Christine LordChapter 37 Intensity-Modulated Radiation Therapy and Inverse PlanningHelen Mayles, John Fenwick, and Steve WebbChapter 38 Electron-Beam Treatment Planning TechniquesAlan McKenzie and David Thwaites (Updated by Philip Mayles)Chapter 39 Proton-Beam Treatment Planning TechniquesFrancesca Albertini, Alessandra Bolsi, and Juliane DaartzChapter 40 Intracranial and Body Stereotactic RadiotherapyJim Warrington and Vivian CosgroveChapter 41 Total Body IrradiationPhilip MaylesChapter 42 Total Skin Electron IrradiationDavid Thwaites and Alan McKenzie (Updated by Philip Mayles)Chapter 43 Dose Evaluation of Treatment PlansMargaret Bidmead and Jean-Claude RosenwaldChapter 44 Radiobiological Evaluation and Optimisation of Treatment PlansAlan Nahum and Eva OnjukkaReferencesPart H Quality AssuranceChapter 45 Quality and Safety ManagementPhilip Mayles, David Thwaites, and Jean-Claude RosenwaldChapter 46 Quality Control of High-Energy External BeamsEdwin Aird, Philip Mayles, and Cephas MubataChapter 47 Quality Assurance of the Treatment Planning ProcessJean-Claude RosenwaldChapter 48 Quality Assurance of Treatment DeliveryMargaret Bidmead, Nathalie Fournier-Bidoz, Ginette Marinello, Jean-Claude Rosenwald, Helen MaylesChapter 49 Data Communication with DICOMJohn Sage, John N.H. Brunt and Philip MaylesReferencesPart I BrachytherapyChapter 50 Brachytherapy Clinical IntroductionPeter HoskinChapter 51 Calibration and Quality Assurance of SourcesColin H. Jones and Chris D. LeeChapter 52 Afterloading Equipment for BrachytherapyMargaret BidmeadChapter 53 Dose Calculation for Brachytherapy SourcesPhilip MaylesChapter 54 Brachytherapy Treatment PlanningMargaret Bidmead, Dorothy Ingham, Peter Bownes and Chris D. LeeChapter 55 Radiobiology of BrachytherapyRoger DaleReferencesPart J Therapy with Unsealed SourcesChapter 56 Radionuclide Selection for Targeted Molecular RadiotherapyCaroline StokkeChapter 57 Targeted Molecular Radiotherapy – Clinical Considerations and DosimetryGlenn Flux and Alan NahumReferencesPart K Radiation Protection in RadiotherapyChapter 58 Theoretical Background to Radiation ProtectionMike Rosenbloom and Philip MaylesChapter 59 Radiation Protection Regulation Mike Rosenbloom and Philip MaylesChapter 60 Radiation Protection of Staff and the PublicMike Rosenbloom and Philip MaylesChapter 61 Radiation Protection of the PatientPhilip Mayles and Uwe SchneiderAppendix K1: A Regulatory Framework (UK examplePhilip MaylesAppendix K2: Example Wall Thickness CalculationsPhilip MaylesAppendix K3: Example Local Rules for Handling Radioactive SourcesMike Rosenbloom and Philip MaylesReferencesPart L Data TablesTables L1 Physical Constants and Useful DataTables L2 Charged Particle Stopping Power and RangeTables L3 Photon Interaction CoefficientsTables L4 Typical Megavoltage Photon Beam Data.

Philip Mayles, formerly of the Clatterbridge Centre for Oncology, UK.Alan Nahum, formerly of the Clatterbridge Centre for Oncology, UK.Jean Claude Rosenwald, formerly at Institute Curie, Paris, France.

Praise for the first edition:"… Due to the broad range of topics covered and the clear, concise explanations, this text would be ideal for anyone wishing to study or refresh their knowledge of any central area of radiotherapy physics. IPEM Part 1 trainees in the UK (and any other trainee following a similar training programme elsewhere) in particular should take note … . Part 2 trainees will also benefit, especially in exploring the excellent source of referenced material. In comparison to other reference texts, the Handbook of Radiotherapy Physics is clear and also filled with many knowledgeable and useful observations and notes. … It is an excellent reference text and sits nicely on the shelf alongside your old copy of Williams and Thwaites."—SCOPE, December 2009"… comprehensive reference … With contributions from renowned specialists, this book provides essential theoretical and practical knowledge to deliver safe and effective radiotherapy." —Anticancer Research, 2009, Vol. 29"The editors have managed with great success to assemble the information submitted by the contributing authors and put it in a format that is concise, easy to read, and rich in content … it can serve as an excellent reference manual and resource." —Niko Papanikolaou, University of Texas Health Sciences Center, Medical Physics, September 2008, Vol. 35, No. 9Praise for the second edition:"This is the 2nd edition of the Handbook of Radiotherapy published in 2007. The book is organized into 11 parts, each dealing with a self-contained subject area including but not limited to Fundamentals, Radiobiology, Equipment, Dose Measurement, Treatment Planning, Quality Assurance, Therapy with Unsealed Sources, and Radiation Protection. An additional part has been included at the end of Vol.2, which provides tables of physical constants and radiation interaction data. This textbook is meant to be a comprehensive handbook practical radiotherapy knowledge for both medical that covers theoretical and physics trainees and practicing medical physicists. It provides a good overview of theoretical knowledge along with a practical description of concepts. In keeping with the original intent of the first edition, this book is intended primarily as course book for physicists in training but could also act as a reference book for practicing radiation physicists. It is a useful supplement to classic radiotherapy textbooks; concepts are introduced very well and extensive references are provided if the readers require a more in-depth review. The editors and authors have wide ranging medical physics experience across the UK, Europe, and U.S.The text is very comprehensive, with sections covering classic topics in the field along with modern topics such as knowledge-based planning, artificial intelligence, and MR-guided linear accelerators. I especially appreciated the quality assurance (QA) part, which included chapters ranging from QA of treatment planning and treatment delivery to data communication with DICOM. Overall, this is a well-written handbook. Due to the extensive changes in the field of medical physics since 2007, this is a necessary and thoughtful update. The editors did a great job of assembling a huge amount of information. Given the breadth and scope of this text, along with the extensive bibliography, this handbook would be a great resource, especially for trainees and early career physicists."—Katelyn Hasse (University of California, San Francisco), in Medical Physics, The International Journal of Medical Physics Research and Practice (July 2022)The treatment of cancer by ionizing radiation – radiotherapy (RT) – has undergone continuous development since the early years of the twentieth century. This book, in two volumes (each containing the contents and index of the complete work) represents a comprehensive updating of the first edition (published in 2007). High-quality RT outcomes depend on close collaboration by radiation oncologists, therapy radiographers (aka radiation technologists), dosimetrists, physicists and, not infrequently, RT equipment engineers. Whilst this book is primarily written by physicists for physicists, some of the material should be useful, even essential, to anyone whose work involves radiotherapy, including those who train such professionals.The book is organised into eleven "parts", covering different topics, plus Part L – data tables – now including the stopping power and ranges of protons (up to 300 MeV kinetic energy) in elements, compounds and mixtures of medical interest. A total of 62 scientists – eminent specialists (from Europe, North America and elsewhere) – have produced the 61 chapters, including colleagues who did not contribute to the first edition. Parts A through C cover the fundamentals of the relevant physics, radiobiology and technology. Parts D through H give the practical information necessary for the support of external-beam RT: dose measurements, clinical beam properties, the computation of dose distributions in patient anatomy, treatment (aka dose) planning and quality assurance. RT delivered with radionuclides is described in Part I (brachytherapy) and Part J (unsealed sources aka "molecular radiotherapy"). Part K covers the radiation protection framework, with an emphasis on the legislation in the UK. We editors hope that our readers will learn as much from reading the book as we have by bringing the 2007 edition up to date. May they be inspired to continue the development of the scientific and technical basis of radiotherapy for the benefit of cancer patients worldwide. –Scope magazine, (December 2022)

• Part A FundamentalsChapter 1 Structure of MatterJean ChavaudraChapter 2 RadioactivityJean ChavaudraChapter 3 Interactions of Charged Particles with MatterAlan NahumChapter 4 Interactions of Uncharged Particles with MatterDavid R. Dance, Jean-Claude Rosenwald, and Gudrun Alm CarlssonChapter 5 Principles and Basic Concepts in Radiation DosimetryAlan NahumReferencesPart B RadiobiologyChapter 6 Radiobiology of TumoursGordon Steel, Catharine West, and Alan NahumChapter 7 Radiobiology of Normal TissuesGordon Steel and Catharine WestChapter 8 Dose Fractionation in RadiotherapyGordon Steel, Catharine West, and Alan NahumReferencesPart C EquipmentChapter 9 Equipment for Patient Data AcquisitionJean-Claude RosenwaldChapter 10 Kilovoltage X-Ray UnitsTony Greener and David EatonChapter 11 Traditional Linear AcceleratorsHamish PorterChapter 12 Machines with Radionuclide SourcesJohn Saunders, Lee Walton, and Katharine HuntChapter 13 In-Room Imaging Devices Used for TreatmentCephas MubataChapter 14 CyberKnife, TomoTherapy and MR-Guided Linear AcceleratorsThomas Lacornerie, Albert Lisbona, and Andrew W. BeavisChapter 15 Accelerators for Protons and Other Heavy Charged ParticlesAlejandro Mazal and Annalisa PatriarcaReferencesPart D Dose MeasurementChapter 16 Ionisation ChambersBryan Muir and Alan NahumChapter 17 Solid-State Dose Measuring DevicesGinette MarinelloChapter 18 Two-dimensional and Three-dimensional DosimetryMark Oldham, Devon Godfrey, Titania Juang, and Andrew ThomasChapter 19 Reference Dose Determination under Reference ConditionsAlan Nahum and Bryan MuirChapter 20 Relative Dose MeasurementsIvan RosenbergReferencesPart E Clinical BeamsChapter 21 The Framework Relating Measurements to Calculation of Delivered DosePhilip MaylesChapter 22 Kilovoltage X-Ray BeamsPhilip MaylesChapter 23 High-Energy Photon BeamsPhilip MaylesChapter 24 Electron BeamsDavid Thwaites and Alan McKenzieChapter 25 Proton and Other Heavy Charged-Particle BeamsAlejandro Mazal and Ludovic de MarziReferencesPart F Patient Dose Calculation MethodsChapter 26 Parameters and Methodology for Point Dose Calculation in Photon BeamsIvan Rosenberg and Jean-Claude RosenwaldChapter 27 Framework for Computation of Patient Dose DistributionJean-Claude RosenwaldChapter 28 Photon Beams: Broad-Beam and Superposition MethodsJean-Claude Rosenwald, Ivan Rosenberg, and Glyn ShentallChapter 29 Charged-Particle Beams: The Pencil-Beam ApproachAlan NahumChapter 30 Monte-Carlo and Grid-Based-Deterministic Models for Patient Dose ComputationAlan Nahum and Jean-Claude RosenwaldReferencesVOLUME 2Preface to the Second EditionThe EditorsList of Contributors to the Second EditionPart G Treatment PlanningChapter 31 Target and Organ at Risk Definition – Dose Prescription and ReportingAnthony Neal and Jean-Claude RosenwaldChapter 32 Computed Tomography Imaging in RadiotherapyNathalie Fournier-BidozChapter 33 Magnetic Resonance Imaging in Treatment PlanningVincent S. KhooChapter 34 Radionuclide Imaging in Treatment PlanningYolande PetegniefChapter 35 Image Registration, Segmentation and Virtual SimulationVibeke Nordmark Hansen and Jean-Claude RosenwaldChapter 36 Photon-Beam Forward Planning TechniquesPeter Childs and Christine LordChapter 37 Intensity-Modulated Radiation Therapy and Inverse PlanningHelen Mayles, John Fenwick, and Steve WebbChapter 38 Electron-Beam Treatment Planning TechniquesAlan McKenzie and David Thwaites (Updated by Philip Mayles)Chapter 39 Proton-Beam Treatment Planning TechniquesFrancesca Albertini, Alessandra Bolsi, and Juliane DaartzChapter 40 Intracranial and Body Stereotactic RadiotherapyJim Warrington and Vivian CosgroveChapter 41 Total Body IrradiationPhilip MaylesChapter 42 Total Skin Electron IrradiationDavid Thwaites and Alan McKenzie (Updated by Philip Mayles)Chapter 43 Dose Evaluation of Treatment PlansMargaret Bidmead and Jean-Claude RosenwaldChapter 44 Radiobiological Evaluation and Optimisation of Treatment PlansAlan Nahum and Eva OnjukkaReferencesPart H Quality AssuranceChapter 45 Quality and Safety ManagementPhilip Mayles, David Thwaites, and Jean-Claude RosenwaldChapter 46 Quality Control of High-Energy External BeamsEdwin Aird, Philip Mayles, and Cephas MubataChapter 47 Quality Assurance of the Treatment Planning ProcessJean-Claude RosenwaldChapter 48 Quality Assurance of Treatment DeliveryMargaret Bidmead, Nathalie Fournier-Bidoz, Ginette Marinello, Jean-Claude Rosenwald, Helen MaylesChapter 49 Data Communication with DICOMJohn Sage, John N.H. Brunt and Philip MaylesReferencesPart I BrachytherapyChapter 50 Brachytherapy Clinical IntroductionPeter HoskinChapter 51 Calibration and Quality Assurance of SourcesColin H. Jones and Chris D. LeeChapter 52 Afterloading Equipment for BrachytherapyMargaret BidmeadChapter 53 Dose Calculation for Brachytherapy SourcesPhilip MaylesChapter 54 Brachytherapy Treatment PlanningMargaret Bidmead, Dorothy Ingham, Peter Bownes and Chris D. LeeChapter 55 Radiobiology of BrachytherapyRoger DaleReferencesPart J Therapy with Unsealed SourcesChapter 56 Radionuclide Selection for Targeted Molecular RadiotherapyCaroline StokkeChapter 57 Targeted Molecular Radiotherapy – Clinical Considerations and DosimetryGlenn Flux and Alan NahumReferencesPart K Radiation Protection in RadiotherapyChapter 58 Theoretical Background to Radiation ProtectionMike Rosenbloom and Philip MaylesChapter 59 Radiation Protection Regulation Mike Rosenbloom and Philip MaylesChapter 60 Radiation Protection of Staff and the PublicMike Rosenbloom and Philip MaylesChapter 61 Radiation Protection of the PatientPhilip Mayles and Uwe SchneiderAppendix K1: A Regulatory Framework (UK examplePhilip MaylesAppendix K2: Example Wall Thickness CalculationsPhilip MaylesAppendix K3: Example Local Rules for Handling Radioactive SourcesMike Rosenbloom and Philip MaylesReferencesPart L Data TablesTables L1 Physical Constants and Useful DataTables L2 Charged Particle Stopping Power and RangeTables L3 Photon Interaction CoefficientsTables L4 Typical Megavoltage Photon Beam Data.