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The alien experiment is alive... and it wants out.In a world where UFO sightings have become alarmingly frequent, the US government's top-secret A.L.I.V.E. Project was created to prepare for an impending alien threat.Dr. Maeve Leander, raised in the shadow of this covert operation, now leads the research on Alvie, the project's first alien subject. To Maeve, Alvie isn't just an experiment; he's family. But when a mysterious new agency seizes control of A.L.I.V.E., Maeve's world is turned upside down.She discovers that Alvie is not the only extraterrestrial being studied - and the truth is far more terrifying than she ever imagined. Suddenly thrust into a deadly game of cat and mouse, Maeve finds herself fighting for her life against both human adversaries and otherworldly forces.As the violence escalates and her chances of survival dwindle, she uncovers a chilling revelation: the project's true goal is to ensure that no one makes it out alive.R.D. Brady's A.L.I.V.E. kicks off a heart-pounding series that masterfully blends government conspiracy with alien encounters. Fans of Douglas E. Richards and Michael Crichton will be captivated by this thrilling page-turner.Brace yourself for a rollercoaster ride through an alternative world where the answer to humanity's greatest question comes at a devastating cost.____________________________Praise for the A.L.I.V.E. Series:★★★★★ From the first book to the last, I could not put them down.★★★★★ What a page turner. The author kept me guessing through the entire book.★★★★★ Stayed up until 2 am because I couldn't put it down.★★★★★ Science gets turned on its head in this tale.★★★★★ Thank you for reigniting my imagination for the other-worldly.★★★★★ Great sci-fi read with enough facts to keep it real. Great action and story line.★★★★★ The main characters are easy to invest in. An antagonist that you will love to hate.★★★★★ Warning...start reading at your own peril as once you do you won't want to stop.

Silverberg's Principles and Practice of Surgical Pathology and Cytopathology is one of the most durable reference texts in pathology. Thoroughly revised and updated, this state-of-the-art new edition encompasses the entire fields of surgical pathology and cytopathology in a single source. Its practice-oriented format uniquely integrates these disciplines to present all the relevant features of a particular lesion, side by side. Over 4000 color images depict clinical features, morphological attributes, histochemical and immunohistochemical findings, and molecular characteristics of all lesions included. This edition features new highly experienced and academically accomplished editors, while chapters are written by the leading experts in the field (several new to this edition, bringing a fresh approach). Dr Steven Silverberg's practical approach to problem solving has been carefully preserved. The print book is packaged with access to a secure, electronic copy of the book, providing quick and easy access to its wealth of text and images.

THE MAN FROM R.I.V.E.R.D.A.L.E. is the first of a chronological collection of titles featuring the adventurous take on Archie Andrews and friends. This is presented in the new higher-end format of Archie Comics Presents, which offers 200+ pages at a value while taking a design cue from successful all-ages graphic novels.The villainous Mad Doctor Doom and his organization C.R.U.S.H. have targeted the students of Riverdale High with a devious plan to turn them into the Walking Dazed! Now it's up to special agent Archie Andrews and his team at R.I.V.E.R.D.A.L.E. to stop them!

Being culturally competent in practice is an essential skill for any practitioner working with people. Award-winning social worker and diversity trainer Vivian Okeze-Tirado has developed an applied practice model to help you to increase your understanding of diversity and improve your cultural competency:D - Decide to be a Culturally Sensitive PractitionerI - Invite people to talk about their cultures, values, beliefs, and experiencesV- Value their history, individuality(,) and differencesE- Explore the client's realities, show curiosityR- Reflect upon information and knowledge receivedS- Scrutinise yourselfI -Identify strategies to aid your workT- Train yourself to treat people, children, and families individuallyY- Yield to culturally sensitive practiceEncouraging you to do more than just talk about racism, this simple practice tool provides easily achievable steps and practical guidance to empower you and your colleagues tackle racism and discrimination in practice.

Some people think that to have an idea of where you want to go is absurd. You, on the other hand, will develop a mind shift to get there.For many years Roy has harnessed and sharpened not only his mind but the minds of his delegates and clients using DRIVE(TM).DRIVE(TM) is a coaching model that has a new and exciting angle. Focussing on the different elements of this model is enlightening and fulfilling.In DRIVE to Peak Performance, Roy A McDonald asks some challenging questions that will create new neural pathways, igniting your mind to conjure up your destination.You can be a top CEO, a business owner or someone who needs direction. Whatever it is, this book will certainly help you turn your vision into reality. "The title is perfect for the book as it is Motivational, Insightful, Inspirational, Interactive, and possibly a mind opener for those who haven't come across the techniques discussed. Surely, it will 'Drive' many people to want to do some work on themselves to see the results that they desire to achieve." Editorial Reviewer Aurea Reis "DRIVE to Peak Performance is a straightforward book, to finally shift you into action towards a goal that has meaning for you. Roy has created a coaching model based on years of business success in the field, combined with his understanding of how the brain works and where real motivation comes from. Most people think they know what to do but can't seem to do it or even more tragically, work really hard, climb a ladder but end up at the top of the wrong ladder, doing a job that has no meaning for them. Roy takes the reader through a step by step process by asking questions, visualisations and exercises which in turn use all three centres of intelligences; the head, heart and gut to create a strategy and a destination which is authentic for you." Teresa Daniels - Enneagram Teacher

Selected as a Doody’s Essential Title for 2025!For 40 years, Fischer’s Mastery of Surgery has provided expert, highly illustrated coverage of the procedures that general surgeons and trainees need to know. The fully revised eighth edition, under the editorial leadership of Drs. E. Christopher Ellison, Gilbert R. Upchurch Jr., Philip A. Efron, Steven D. Wexner, Nancy D. Perrier, V. Suzanne Klimberg, John H. Stewart IV, Valerie W. Rusch, Jon C. Gould, Susan Galandiuk, Timothy M. Pawlik, William C. Chapman, Benjamin K. Poulose, Peter K. Henke, Alicia M. Mohr, Saleem Islam, Anne M.R. Agur, Carol Scott-Conner, and David Renton continues the tradition of excellence with two full-color volumes that include the essentials of diagnosis, anatomy, and pre-operative planning while maintaining a focus on clear, step-by-step depictions and descriptions of procedures.  Brings you up to date with evidence-based approaches for virtually any surgery you’ll be called upon to perform  Provides extensive coverage (including select procedural videos) of common thoracic, breast, esophageal, endocrine, colorectal, gastric, pancreatic, liver, biliary, vascular, and transplantation procedures across 311 chapters  Includes new sections on perioperative care and critical care; abdominal core health; trauma, burn, and acute care surgery; and pediatric surgery as well as new Mastery Keys anatomy chapters  Walks you step by step through each procedure, with tips and cautions from leading surgeons  Concludes each chapter with expert editorial commentary that puts the chapter material in a broad context and provides helpful critiques of the most recent literature  Features more than 2,600 illustrations and photographs that offer a surgeon’s-eye-view of the most advanced approaches  The VST Ebook includes 85 videos of procedures presented in the book!   Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone.  Easily convert to audiobook, powering your content with natural language text-to-speech.

This book is Volume 2 of the EUROCK 2018 proceedings. Geomechanics and Geodynamics of Rock Masses contains contributions presented at EUROCK 2018, the 2018 International Symposium of the International Society for Rock Mechanics (ISRM 2018, Saint Petersburg, Russia, 22-26 May 2018). Dedicated to recent advances and achievements in the fields of geomechanics and geotechnology, the main topics of the book include:- Physical and mechanical properties of fractured rock (laboratory testing and rock properties, field measurements and site investigations)- Geophysics in rock mechanics- Rock mass strength and failure- Nonlinear problems in rock mechanics- Effect of joint water on the behavior of rock foundation- Numerical modeling and back analysis- Mineral resources development: methods and rock mechanics problems- Rock mechanics and underground construction in mining, hydropower industry and civil engineering- Rock mechanics in petroleum engineering- Geodynamics and monitoring of rock mass behavior- Risks and hazards- Geomechanics of technogenic depositsGeomechanics and Geodynamics of Rock Masses will be of interest to researchers and professionals involved in the various branches of rock mechanics and rock engineering. EUROCK 2018, organized by the Saint Petersburg Mining University, is a continuation of the successful series of ISRM symposia in Europe, which began in 1992 in Chester, UK.

The International Committee on Large Dams (ICOLD) held its 26th International Congress in Vienna, Austria (1-7 July 2018). The proceedings of the congress focus on four main questions: 1. Reservoir sedimentation and sustainable development; 2. Safety and risk analysis; 3. Geology and dams, and 4. Small dams and levees. The book thoroughly discusses these questions and is indispensable for academics, engineers and professionals involved or interested in engineering, hydraulic engineering and related disciplines.

Cytosol, the liquid found inside cells, is the site for multiple cell processes, including signaling from the cell membrane to sites within the cell. Cytosolic signaling mechanisms are researched and studied in graduate programs in cell biology, molecular biology, biochemistry, pharmacology, molecular and cellular physiology, pharmacy, and biomedical sciences. Articles written and edited by experts in the field Thematic volume covering material needed for young professionals joining the field of research and graduate students taking survey courses Up-to-date research on signaling systems and mutations in transcription factors that provide new targets for treating disease

In this volume, members of the International Translational Research Network on Orofacial Neurological Disorders and invited experts provide authoritative overviews of new aspects of motor function and sensation relating to neurological disorders in orofacial regions. Orofacial movements constitute fundamental motor patterns with essential roles in consummatory behavior, self-care, defensive and attack behaviors, vocalization and, in higher mammals, verbal as well as non-verbal communication. Clinically, dysfunction in orofacial movement is evident in numerous dental, cranio-maxillo-facial and neuropsychiatric disorders, including dysphagia, Huntington's disease, Parkinson's disease and schizophrenia.

Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.

This volume of Methods in Enzymology aims to provide a reference for the diverse, powerful tools used to analyze RNA helicases. The contributions in this volume cover the broad scope of methods in the research on these enzymes. Several chapters describe quantitative biophysical and biochemical approaches to study molecular mechanisms and conformational changes of RNA helicases. Further chapters cover structural analysis, examination of co-factor effects on several representative examples, and the analysis of cellular functions of select enzymes. Two chapters outline approaches to the analysis of inhibitors that target RNA helicases.

This volume of Methods in Enzymology aims to provide a reference for the diverse, powerful tools used to analyze RNA helicases The contributions in this volume cover the broad scope of methods in the research on these enzymes

Introduction to Biological and Small Molecule Drug Research and Development provides, for the first time, an introduction to the science behind successful pharmaceutical research and development programs. The book explains basic principles, then compares and contrasts approaches to both biopharmaceuticals (proteins) and small molecule drugs, presenting an overview of the business and management issues of these approaches. The latter part of the book provides carefully selected real-life case studies illustrating how the theory presented in the first part of the book is actually put into practice. Studies include Herceptin/T-DM1, erythropoietin (Epogen/Eprex/NeoRecormon), anti-HIV protease inhibitor Darunavir, and more.

Introduction to Biological and Small Molecule Drug Research and Development is intended for late-stage undergraduates or postgraduates studying chemistry (at the biology interface), biochemistry, medicine, pharmacy, medicine, or allied subjects. The book is also useful in a wide variety of science degree courses, in post-graduate taught material (Masters and PhD), and as basic background reading for scientists in the pharmaceutical industry.

For the first time, the fundamental scientific principles of biopharmaceuticals and small molecule chemotherapeutics are discussed side-by-side at a basic level Edited by three senior scientists with over 100 years of experience in drug research who have compiled the best scientific comparison of small molecule and biopharmaceuticals approaches to new drugs Illustrated with key examples of important drugs that exemplify the basic principles of pharmaceutical drug research and development

The upcoming 5G specifications from 3GPP, to be available in 2018, will include LTE-Advanced Pro as well as a new 5G radio-access technology. This practical and very successful book, written by engineers working closely with 3GPP, gives insight into the newest technologies and standards adopted by 3GPP, with detailed explanations of the specific solutions chosen and their implementation in LTE, LTE-Advanced, and LTE-Advanced Pro, as well as providing a detailed description of the path to 5G and the associated underlying technologies.

This edition has been thoroughly revised and updated to reflect the large extensions to LTE as introduced in 3GPP Releases 12 and 13 and the role of LTE in the upcoming 5G era. New to this edition includes updated content on:

4G and 5G Radio Access Spectrum for 4G and 5G Machine-Type Communication Device-to-Device Communication License-assisted Access Full-dimension MIMO Small-cell enhancements, eIMTA, FDD+TDD aggregation, dual connectivity Requirements on and general structure of 5G wireless access, addressing the existing and new usage scenarios for 5G Technical solutions for the new 5G radio-access technology

The authors of this book all work at Ericsson Research and have been deeply involved in 3G and 4G development and standardization. They are leading experts in the field and are today actively contributing to the standardization of 4G and 5G within 3GPP.

The leading book on 3GPP specifications for LTE, LTE-Advanced, and LTE-Advanced Pro covering up to and including Release 13, written by Ericsson engineers who are heavily involved in the development of 3GPP specifications Ten new chapters and coverage of all major features introduced with Release 12 and 13 Two completely new chapters on 5G wireless access including a detailed description of the key technology components under development by 3GPP

The Neuroscience of Dementia brings together different fields of dementia research into a single book, covering a wide range of subjects, including Alzheimer’s disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, molecular biology, and more. This foundational, comprehensive book compiles the latest understanding on all forms of dementia and their common features in a single source. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field.

Quantum Systems in Physics, Chemistry and Biology, Theory, Interpretation, and Results, Volume 78, the latest release in the Advances in Quantum Chemistry series presents surveys of current topics in this rapidly developing field that has emerged at the cross section of the historically established areas of mathematics, physics, chemistry and biology. It features detailed reviews written by leading international researchers.

Presents surveys of current topics in this rapidly-developing field that has emerged at the cross section of the historically established areas of mathematics, physics, chemistry and biology Features detailed reviews written by leading international researchers

5G NR: The Next Generation Wireless Access Technology, Second Edition, follows the authors' highly celebrated books on 3G and 4G and provides a new level of insight into 5G NR. After background discussion of 5G, including requirements, spectrum aspects, and the standardization timeline, all technology features of the first phase of NR are described in detail. The book covers the NR physical-layer structure and higher-layer protocols, RF and spectrum aspects, and co-existence and interworking with LTE. The book provides a good foundation in NR and different NR technology components, giving insight into why a certain solution has been selected.This second edition is updated to reflect the latest developments in Release 16 and includes brand new chapters on: NR in unlicensed spectrum; NR-U in Rel-16; IAB; V2X and sidelink in Rel-16; industrial IoT; IIoT and referring to the URLLC enhancements for PDCCH; RIM/CL; and positioning. Also included are the key radio-related requirements of NR; design principles; technical features of basic NR transmission structure-showing where it was inherited from LTE, where it deviates from it, and the reasons why- NR multi-antenna transmission functionality; detailed description of the signals and functionality of the initial NR access, including signals for synchronization and system information; random access and paging; LTE/NR co-existence in the same spectrum and the benefits of their interworking as one system; and different aspects of mobility in NR. RF requirements for NR are described for BS and UE, the legacy bands, and for the new mm-wave bands. Gives a concise and accessible explanation of the underlying technology and standards for 5G NR radio-access technology Provides detailed description of the NR physical-layer structure and higher-layer protocols, RF and spectrum aspects, and co-existence and interworking with LTE Gives insight not only into the details of the NR specification, but also an understanding of why certain solutions look like they do Includes the key radio-related requirements of NR, design principles, and technical features of basic NR transmission structure

Diagnostic Molecular Biology, Second Edition provides an up-to-date comprehensive overview of the latest advances in molecular diagnostics and the fundamental molecular aspects in this area. The book delves into the essential principles behind the transmission and expression of genetic information, including nucleic acids, proteins, and chromosomes, specifically their genome structure, life cycle, and evolution. The latest methods and instrumentation in the field are examined with detailed procedures and explanations provided for each technique. A range of techniques are also investigated, such as those used in sequencing analysis, genome and transcriptome analysis, and nucleic acid amplitification techniques. This book covers the collection, isolation, and purification of DNA, RNA, and protein from different sources. Additionally, discussion on the applications of next-generation sequencing (NGS) and the role of NGS in the future of precision medicine is included. The book also examines the use of molecular diagnostics for chromosomal disorders, inherited diseases, and infectious diseases. Moreover, this new edition features recent advances in the detection of respiratory virus infections in humans, including that of SARS-CoV2. Diagnostic Molecular Biology, Second Edition, is an ideal reference for researchers, lab technicians, and students in medical laboratory science, molecular biology, microbiology, virology, and related fields.

Provides explanations on how techniques are used to diagnosis at the molecular level Explains how to use information technology to communicate and assess results in the lab Enhances our understanding of fundamental molecular biology and places techniques in context Places protocols into context with practical applications Includes extra chapters on respiratory viruses (Corona)

The latest edition of this in-depth look at athletic injuries of the shoulder has been updated to feature 16 new chapters, additional illustrations and algorithms, an added focus on arthroscopic treatments, and pearls that highlight key information. Additional contributing authors give you a fresh spin on new and old topics from rehabilitation exercises to special coverage of female athletes, pediatrics, and golfers. This book offers coverage of arthroscopy, total joint replacement, instability, football, tennis, swimming, and gymnastic injuries, rotator cuff injuries, and much, much more! The large range of topics covered in this text ensures that it's a great resource for orthopaedists, physical therapists, athletic trainers, and primary care physicians.