Advances in Enzyme Regulation – serie

Stepping ahead of the general front, Volume 41 in the series Advances in Enzyme Regulation moves the studies of mammalian enzymic and metabolic regulation forward.

This volume was dedicated on the centenary of his birth to Sir Hans A. Krebs who gave the Special Symposium lectures for 15 years. George Weber spoke on the joint work he carried out in Oxford with Krebs and his associates, entitled "Cancer and Clinical Targeting."

Much of the Symposium centered on novel aspects of signal transduction, including Inositol Signaling and on phosphatidylinositol 3'kinase and kinase B. The Special Symposium Lecture was given on Inositol Lipid Signaling in the Nucleus.The location and regulation of protein kinases were discussed.Clinical aspects of enzyme regulation were presented featuring studies on dihydrophyrimidine dehydrogenase, development, citrullinemia and human melanoma heparanase.Drug targeting and resistance were reviewed featuring etoposide and tumor vasculature. Regulation of pyruvate dehydrogenase kinase and abrogration of cytokine-dependency were analyzed. Challenging results on mRNA stability and apoptosis were presented covering cyclooxygenase-2 inhibitors, lysosomal cathepsins, human breast tumors and actin reorganization. The contents listed below provide a complete overview of topics and speakers.

Volume 42 lives up to its goal of advancing a few steps ahead of the general front of mammalian enzymic and metabolic regulation studies. This volume contains papers of 25 outstanding scientists working at the cutting edge of metabolic regulation. Much of the volume focuses on novel aspects of signal transduction with an emphasis on nuclear expression.

One of the highlights of this volume is the Special Symposium Lecture. This was given for 15 years by Sir Hans A. Krebs who passed away 20 years ago. It was now given by Professor Sir Hans L. Kornberg, University Professor at Boston University.

These volumes continue to be a source of information and inspiration and a laboratory and advanced teaching companion. The immediate and long-range significance of these cutting-edge presentations of these novel topics should be immediately clear to the reader.

This volume contains papers of 23 outstanding scientists who are working at the leading edge of metabolic regulation studies. Much of the volume focuses on novel aspects of signal transduction with emphasis on the role of phospholipase C in cell control mechanisms.

One of the highlights of this volume is always the Special Symposium Lecture. This lecture was given for fifteen years by Nobel laureate, Sir Hans A. Krebs (UK) (now deceased). This year the Lecture was given by Nadir Maraldi, Director of the Laboratory of Cellular Biology and Electron Microscopy, University of Bologna, Italy. Professor Maraldi's presentation is on the important and novel subject of "Nuclear Proteins and Human Disease."

A direct spinoff of the Advances in Enzyme Regulation journal this internationally acclaimed series reports progress at the cutting edge in the strategic area of regulation at the molecular level. In an integrated presentation of original papers, leading scientists, Nobel Prize winners and other outstanding experts from many countries review the best research produced each year and evaluate what is newest and what promises to be the most important in clinical and basic investigations. The volumes serve as guideposts and beacons for investigators in planning research and teaching students in basic and clinical fields of endeavour. These books advance the general front of studies on metabolic regulation and the understanding of the molecular biology of control of gene expression by hormones, drugs and growth factors in cancer cells and in clinical situations of diabetes, inborn errors of metabolism and neoplasia.