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Del 6 - Agents and Actions Supplements
Prostaglandins and Inflammation
Conference, London, 1979
AvRainsford,Ford-Hutchinson
Häftad, Engelska, 2012
567 kr
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Since prostaglandins were first proposed as mediators of in flammation some eight years ago, there have been a variety of arachidonic acid metabolites discovered including the thromboxa nes, prostacyclin, prostaglandin endoperoxides and lipoxygenase products such as SRS-A. All of them have subsequently been shown to have significant and specific biological activities not only in inflammatory responses but also in other physiological pro cesses. The explosion of research in this area has been an indi cation of the importance of this field but has also meant that it is time for an evaluation of activities of prostaglandins and products of the arachidonate pathway - collectively described as eicosanoids. For this reason the organizers of this conference felt it was timely to bring together workers in the field and critically evaluate some aspects of the role of different eico sanoids in inflammatory responses and the action of the anti inflammatory agents drugs used to modulate or inhibit these responses. The conference held at King's College Hospital Medical School produced lively and constructive discussions. While there are still many complexities to be investigated several important conclusions did emerge. The organizers were grateful to have the use of facilities at Normanby College and King's College Hospi tal. Also we would like to thank the Boots Company Ltd. , for generous sponsorship and Mrs. P. Carter for valuable secretarial assistance. K. D. Rainsford A. W. Ford-Hutchinson M. J. H. Smith Organizers. Lewis 7 INTRODUCTION TO PROSTAGLANDINS AND INFLAMMATION G. P.
Del 16 - Agents and Actions Supplements
Cologne Atherosclerosis Conference No. 2: Lipids
2nd Cologne Atherosclerosis Conference, Cologne, May 2–4, 1984
AvParnham
Häftad, Engelska, 2012
567 kr
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This book contains the proceedings of the 2nd Cologne Ath~roscle- rosis Conference (CAC) which was devoted to lipids, in particular lipoproteins. The object of the conference series, organised by A. Nattermann & Cie. GmbH, Cologne, is to provide an overview of various fields either directly related to or associated with the process of atherosclerosis. Having considered the associated field of inflammation in the first conference, the 2nd CAC dealt with a subject intimately related to the atherosclerotic process per see The recent demonstration in an extensive clinical study of a close link between high plasma cholesterol and coronary mortality has awakened both the medical and the lay communities to the importance of research into lipoprotein biochemistry and physiology. This can only be good news since more intensive research into lipoprotein functions is vital for future therapy of atherosclerosis and other lipid disorders. The status of research on lipoproteins is reflected in the contributions to this book, which are of an interdisciplinary nature, including both reviews and shorter research reports by acknowledged experts in the field.Special thanks are due to Margret Leffin for her organisational and secretarial assistance at all stages and to Dr. D. Bowyer and Prof. W. Stoffel for their advice and assist- ance with the programme. Cologne, July 1984 Michael J *. Parnham Lipoprotein Synthesis and Receptor Interactions 17 AAS 16: 2nd Cologne Atherosclerosis Conference 1984 (c) 1984 Birkhiiuser Verlag Basel APOLIPOPROTEIN GENES, DNA POLYMORPHISMS AND HYPERLIPIDEMIA c. c. Shoulders and F. E.
Prostaglandins in the Cardiovascular System
AvSinzinger,Schrör
Häftad, Engelska, 2012
543 kr
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Del 46 - Agents and Actions Supplements
Novel Molecular Approaches to Anti-Inflammatory Therapy
AvWaldemar Pruzanski,Peter Vadas
Häftad, Engelska, 2013
567 kr
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In July 1994, the Canadian Inflammation Society in Toronto hosted a symposium entitled "Novel molecular approaches to anti-inflammatory therapy" as a satellite of the xnth International Congress of Pharmacology. For several reasons the above topic was singled out and separated from the general Congress. Major advances have recently been made in the understanding of inflammatory mechanisms. These advances serve as the basis for a new generation of therapeutic agents which may potentially alter our approach to inflammatory processes and infectious diseases. The Satellite Symposium focused on recent advances in diversified fields including arachidonate metabolites, actions of cytokines, chemokines, cellular adhesion molecules and novel molecular approaches in the therapy of inflammation. Scholarly addresses were presented by eminent experts in their respective fields. In this book are included 17 papers which describe in detail novel approaches to the study of inflammation. We hope that this book will serve not only as a summary of present knowledge, but will stimulate both scientists and clinicians to continue their efforts to battle inflammatory diseases. W. Pruzanski, Chair, Publications Committee P. Vadas, Chair, Organizing Committee 1 AAS46 Novel Molecular Approaches to Anti-Inflammatory Theory © 1995 Birkhauser Verlag Basel EOSINOPHIL CHEMOATIRACTANIS GENERATED IN VIYO T. I. Williams, D. A. Griffiths-Iohnson, P. I. lose and P. D. Collins. Department of Applied Pharmacology, National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, United Kingdom.
Del 29 - Agents and Actions Supplements
Risk Factors for Adverse Drug Reactions — Epidemiological Approaches
AvWeber,Lawsonm. fl.
Häftad, Engelska, 2012
543 kr
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The benzodiazepines are among the most widely-used of drugs. However, in many countries their popularity is waning as prescribers become more aware of problems with unwanted effects and with rebound and withdrawal syndromes. The earlier benzodiazepines were long-acting, and it was thought that their shorter-acting successors would have important advantages. Other developments include partial agonists and partial inverse agonists, compounds acting on the benzodiazepine-GABA macro molecular site although not as a typical benzodiazepine, and anxiolytic agents acting on 5-HT pathways directly. I shall review the problems of unwanted effects and dependence, mainly from an epidemiological view point, and then relate the pharmacological properties of the newer com pounds to possible differences in their clinical profile of adverse effects. Adverse behavioural effects Benzodiazepines are used, inter alia, as anxiolytics and hyp notics. The latter use exploits the sedative actions which occur at higher than anxiolytic doses. The sedation should disappear by the time the patient wakes up. Hypnotics are thus unique in that their wanted effect and unwanted effect are identical - sedation - but separated in time by about 8 hours.
New Perspectives in Histamine Research
AvH. Timmermann
Häftad, Engelska, 2012
550 kr
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Histamine is an intriguing compound; the same is true for the several classes of anti-histaminergic compounds. The classical anti-histamines, now known as H -antagonists have 1 been the result of intensive research in the 1950s and 1960s. The new, so-called non-sedating H1-antagonists, which became available in the 1980s, could be d'eveloped mainly due to insights into structural features causing the sedating effects of the older compounds. In the 1970s the H2-receptors became important targets for developing new anti-ulcer agents. The H2-antagonist story is a stimulating example of modern research on pharmacology and medicinal chemistry. Unknown and new properties of histamine and histaminergic systems came to the attention of the pharmacologists and medicinal chemists in the 1980s. The role of histamine as a neurotransmitter, the existence of a presynaptic receptor (H ) controlling the release of histamine 3 and other neurotransmitters, and the particular character of this receptor became important as the possibilities to design new therapeutic agents were realized. Recently, other roles of the histaminergic systems have been suggested. Is there a distinct histamine receptor involved in immunological features of histamine? Is histamine involved in the prolactin axis? Are histamine receptors intracellularly present in certain cells and what is their possible role? For these reasons it was the right time to discuss "New Perspectives in Histamine Research" during a scientific meeting. Therefore a symposium was organized as a satellite of the XIth International Congress of Pharmacology of IUPHAR in Amsterdam in 1990.
Recent Progress on Kinins
Biochemistry and Molecular Biology of the Kallikrein-Kinin System
AvBönner,Fritz
Häftad, Engelska, 2012
567 kr
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Del 43 - Agents and Actions Supplements
New Drugs in Allergy and Asthma
AvT.T. Hansel,Morley
Häftad, Engelska, 2012
567 kr
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Readers will be aware that asthma is one of the commonest chronic diseases of industrialised societies, with an increase in morbidity and mortality, despite the availability of a range of different drugs. In an effort to improve the treatment of asthmatic patients, international guidelines have recently recognised asthma as an inflammatory disease, and there has been a change in emphasis from bronchodilator drugs towards earlier use of anti-inflammatory treatments. This volume brings together the latest developments in our understanding of the mechanisms of asthma, considers the safety ofbeta-adrenoceptor agonists, and explores latest developments in the use of phosphodiesterase (PDE) inhibitors in asthma therapy. The second international conference on "New Drugs in Allergy and Asthma" was held in Davos on 8-10 July 1992. There were six sessions with specialist chairmen: PDE isoenzymes (c. D. Nicholson), atopy and the environment (8. Villiger), adhesion molecules (R. H. Gundel), cytokines (M. Baggiolini), airway hyperreactivity (S. Makino) and neurotransmitters (J. G. Widdicombe). The success of the meeting was ensured by a high standard of presentation, with extensive reference to recent experimental data. The chairmen were instrumental in fostering stimulating discussion periods, that considerably enlivened the meeting. Particular thanks are due to the Swiss Institute for Asthma and Allergy Research (SIAF) and also to the e1inicians of Davos for their assistance and hospitality. In addition, a number of pharmaceutical companies were kind enough to support this meeting that was devoted to academic aspects of drug discovery. John Morley FRCPath.
Del 47 - Agents and Actions Supplements
Inflammation: Mechanisms and Therapeutics
AvNiall S. Doherty,Barry M. Weichmannm. fl.
Häftad, Engelska, 2012
567 kr
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The Seventh International Conference of the Inflammation Research Association, entitled "Inflammation, Mechanisms and Therapeutics" was held on September 25-29,1994 in White Haven, Pennsylvania. The major focus of this series of conferences is the multidisciplinary investigation of inflammation and the discovery of novel therapeutic approaches to inflammatory diseases. It was therefore particularly gratifying that the list of attendees included scientists of diverse backgrounds - preclinical biology, synthetic and theoretical chemistry, biotechnology and clinical research. The Conference was characterized by a very high degree of participation in the scientific debate by attendees, a large proportion of whom presented at poster sessions, poster discussions and workshops, and by the many opportunities for informal discussion provided by the organizers. This volume captures much of the excitement and enthusiasm of the Conference and should be a valuable resource for scientists in the field. Niall S. Doherty Barry M. Weichman Douglas W. Morgan Lisa A. Marshall IX Acknowledgments The manuscripts contained in this volume are based on material presented at the Seventh International Conference of the Inflammation Research Association held in White Haven, Pennsylvania, on September 25-29,1994. We would like to thank the speakers and session chairpersons for their contributions to the Conference and these Proceedings. The following individuals played indispensable roles in the organization and running of the Conference and are responsible for making it such a success: PLANNING SCHOLARSHIP Niall S. Doherty Janet Kerr, Chairperson Barry M. Weichman Richard Carlson Douglas Morgan Richard Harris Loran Killar D.
Mediators in the Cardiovascular System: Regional Ischemia
AvKarsten Schrör,Cecil R. Pace-Asciak
Häftad, Engelska, 2012
1 126 kr
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One of the currently most expanding and exciting areas in cardiovascular research is the study of receipt and dispatch of chemical signals by different cell types. Major progress has been made during the last years and a number of intercellular mediators have been structurally identified and their regulation studied. The impressive developments in molecular biology have provided most effective tools, enabling us to understand message generation in much more detail than anyone would have appreciated a couple of years ago. These developments also have a major impact on cardiovascular pharmacology. This involves both the molecular design of new drugs as well as an improved understanding of how established drugs act. Clearly, changes in one mediator system will also affect others and it might be difficult to take out just one factor and to ignore others. This is definitely true for myocardial ischemia where many different mediators are synthesized and released at about the same time, resulting in a complex picture of events and an even more difficult selection of the most appropriate drug therapy.
Del 48 - Agents and Actions Supplements
Prostaglandins and Control of Vascular Smooth Muscle Cell Proliferation
AvK. Schrör,P. Nev
Häftad, Engelska, 2012
567 kr
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Uncontrolled proliferation of vascular smooth muscle cells (SMC) in response to vessel injury is a problem with a considerable therapeutic impact. Specifically, restenosis after percutaneous transluminal coronary angioplasty (PTCA) is a clinical problem without any effective drug therapy so far. Thus, there is need for an improved drug therapy but also for an improved understanding of the pathophysiology of growth control in SMC. Cyclooxygenase products, such as prostaglandins and thromboxane, are intimately involved in growth responses. Vasodilatory prostaglandins, such as PGI , PGE or their analogues, have 2 1 been shown to inhibit SMC proliferation. There is also evidence for a markedly increased endogenous prostaglandin production during neointirna formation under the influence of growth factors which includes induction of COX-2. These data suggest that prostaglandins might be considered both targets and tools of growth control. However, there are still many open questions, including the possible interaction of prostaglandins with other growth modulating factors, in particular NO, the intracellular signal transduction pathways and the role of oxidative stress.
Del 31 - Agents and Actions Supplements
Mediators in Airway Hyperreactivity
AvNijkamp,Engelsm. fl.
Häftad, Engelska, 2012
543 kr
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Del 40 - Agents and Actions Supplements
Update on Childhood Asthma
AvM.H. Schöni,Kraemer
Häftad, Engelska, 2012
567 kr
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This volume of "Agents and Actions Supplements" provided a challenge to the editors, the authors and the publisher. It was our aim to complete the book in advance of the lectures to be given at the "International Symposium on Asthma and Allergic Diseases in Childhood", in Berne, Switzerland, on March 25th-27th, 1993. This symposium commemorates the 10th anniversary of the Swiss Association of Parents of Asthmatic and Allergic Children. The incidence of asthma and allergies generally is on the increase and demands everyone's attention, including that of physicians, researchers, allied health professionals and parents. There have been no recent breakthroughs in our understanding of asthma pathogenesis or treatment. However, forms of treatment, pathogenetic insights and public awareness are undergoing rapid changes as our knowledge of atopic diseases increases. For this reason we chose the title "Update on Childhood Asthma". The purpose of the papers is to summarize recent research results, to provide an update on the current approach to therapeutic interventions and to alert readers to the psychosomatic aspects of asthma. Whether the state of knowledge has already changed while you are holding this book in your hands is not so much dependent on a delay in publishing but on the speed of appearance of new research results. Fortunately, our ambitious target to edit the proceedings in advance of the conference has been successful. This was only possible because of the timely submission of papers, the speed of publication and the enthusiasm of the editors.
Del 42 - Agents and Actions Supplements
Proteases, Protease Inhibitors and Protease-Derived Peptides
Importance in Human Pathophysiology and Therapeutics
AvJ. Cheronis,Repine
Häftad, Engelska, 2012
567 kr
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Proteases, Protease-Derived Peptides and Protease Inhibitors Many physiological as weil as pathophysiological processes are mediated by proteases and the products of their actions, protease-derived peptides. However, the uncontrolled activity of proteases can be extraordinarily destructive and dangerous to normal biologie systems. As a result, biology has gone to great lengths to control the activities of the proteases involved in these systems by developing aseries of both highly specific (regulatory) and non-specific (protective) anti-proteases. The protease/anti-protease balancing activities include the normal homeostatic processes of clotting and clot lysis, hormonal regulation of blood pressure and the control of the inflammatory response represented by both the humoral (the kallikrein-kinin and complement systems) and cellular (neutrophil and macrophage derived proteases) components of the inflammation. Examples of successful therapies directed at these protease dependent systems include the use of warfarin and heparin to control thrombosis and streptokinase or tissue plasminogen activator (tPA) for the acceleration of clot dissolution.Similarly, the use of angiotensin converting enzyme (ACE, a type of limited activity protease or peptidase) inhibitors has made a significant impact on the treatment of hypertension. Lastly, the restitution of normal antiprotease levels by the infusion of the purified protein in patients with genetic alpha-1-antiprotease deficiency is regularly being used to reduce the rate of lung function 1055 caused by the unopposed activity of human neutrophil elastase in these individuals.
Del 32 - Agents and Actions Supplements
Drugs in Inflammation
AvMichael Parnham,Michael A. Braym. fl.
Häftad, Engelska, 2012
567 kr
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On June 28-29, 1990 in Noordwijk, The Netherlands, the International Association of Inflammation societies (IAIS) organized their first symposium on Drugs in Inflammation. The symposium was an official satellite of the Ixth International Congress of Pharmacology (IUPHAR). This volume contains the proceedings from this satellite meeting. The IAIS was constituted in 1988 when representatives of the Inflammation Research Association (IRA), European Workshop on Inflammation (EWI) and British Inflammation Research Association (BIRAs) met at White Haven, Pennsylvania during the Fourth International Conference of the IRA and the group decided that improved communication between inflammation societies could be achieved by establishment of a society. The IAIS would encourage and foster collaboration between the many inflammation societies throughout the world and assist in the establishment of new societies whenever possible. The satellite was a major success thanks to the efforts of the planning committee: Wim van den Berg, the local organizer, Mike Bray, the programme chairman, Rodger McMillan, Greg Harper, Mike Parnham and Kay Brune. In addition, the chairman and presenters ensured the scientific content of the meeting was of a very high standard. Most importantly, the 100 participants from 15 countries made the sessions lively and interactive. The IAIS will hopefully organize additional symposiums in the future. Alan J. Lewis, Ph.D.
Del 39 - Agents and Actions Supplements
Joint Destruction in Arthritis and Osteoarthritis
AvW.B. van den Berg
Häftad, Engelska, 2012
567 kr
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On May 24-27,1992 the European Society ofOsteoarthrology (ESOA) held its 19th sympo- sium in Noordwijkerhout, The Netherlands. The symposium was entitled "Joint destruction in arthritis and osteoarthritis" and sought to combine both clinical and experimental studies in this field. The present volume contains the proceedings of this meeting. The ESOA has organized most of its symposia in the eastern part of Europe, thanks to major input from Stanislav Havelka, who in recent years has been supported by Heikki Helminen. In appreciation of his efforts Stan Havelka was granted Honorary Presidentship of the ESOA at the meeting. In the era of European unification it seemed desirable to create a strong Uni- fied European Society, which would organize major meetings in both parts of Europe. Cartilage and bone research is expanding rapidly and the number of meetings in this field is continually growing. In line with these developments discussions took place with the recent- Iy founded "Eular Workshop on Bone and Cartilage Research" and the "Osteoarthritis Re- search Society (OARS)".
Del 21 - Agents and Actions Supplements
PAF, Platelets, and Asthma
AvM. Schmitz-Schumann,Menzm. fl.
Häftad, Engelska, 2012
543 kr
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Bronchial asthma is a disease with many unsolved problems and despite an increased availabili ty of anti-asthma drugs, morbidi ty and mortality from this disease are not improving. It is now recognized that asthma should be considered as a chronic inflammatory disease of the lung resulting in bronchial hyperreactivity and subsequent symptoms. The mechanisms underlying airways inflammation and bronchial hyperreactivity have now become a focal point of research in the quest for knowledge about how the management of this disease can be improved. Platelet activating factor (PAF-acether AGEPC) is a naturally occurring ether-linked phospholipid discovered in 1972 associated with IgE mediated allergic responses which has potent effects on platelet activation. PAF is now recognized as a molecule having a diverse range of biological effects relevant to allergic inflammation and asthma including the abili ty to induce long lasting airway inflammation and associated increases in bronchial reactivity. Certain activities of PAF are known to be secondary to platelets activation raising the possibility that this blood element plays a role in the pathogenesis of asthma.
Del 30 - Agents and Actions Supplements
Inflammatory Indices in Chronic Bronchitis
AvPersson,Agentm. fl.
Häftad, Engelska, 2012
543 kr
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Epidemiological studies of Chronic Bronchitis/ Chronic Obstructive Airway Disease (CB/COAD) have demonstrated that hypersecretory glandular activity, as weIl as infections, are not the most important risk factors determining the serious decline in lung function in this disease. Instead, inflammatory indices are emerging as characteristic features of the pathology and pathophysiology of CB/COAD. It is possible that continuous inflammatory processes cause structural changes and thus provide the anatomical basis for airway obstruction which, once estab lished, is only partly reversible. We feIt it was timely to gather leading international researchers who could provide critical updates on CB/COAD, its pathology and clinical/ experimental assessments. The latter aspect included not only the fundamentals of airway function but also, and in greater detail, cellular and solute indices which can now be used to determine inflammation in CB/COAD. The meeting was made possible by a grant from Draco/Astra (Sweden and Finland). We particularly acknowledge the expert assistance of Mrs. Eva Engberg in all facets of the present work.
Del 18 - Agents and Actions Supplements
Recent Advances in Connective Tissue Research
26th–29th May, 1985, at Salamander Bay, Port Stephens, N.S.W., Australia
AvGosh
Häftad, Engelska, 2012
550 kr
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The contri buti ons to the workshops inc 1 uded short revi ews by i nvi ted speakers as well as research papers sel ected by the Chai nnen from the poster abstracts received. The afternoons were free for discussion and recreation but delegates reassanbled with the help of Hunter Valley Wines two hours before dinner to review the many posters presented. On the evenings of the 27th and 28th May, four review lectures were given by J. Dingle (The role of messengers of the IL-I/Catabolin type in cartilage turnover), R. Poole (Immunochemistry as applied to the study of connective tissues), W. Comper (Biophysical aspects of fluid movement in proteoglycan matrices) and P. Roughl ey (Cha nges in proteoglycan structure duri ng cartil age agei ng - ori gi n and effects). The workshop sessions and review lectures, while intense, provided much new data in the areas defined and provided useful debates on controversial issues, which in some instances still remain unresolved.However, the relaxed, informal atmosphere of the Salamander Bay resort provided the greatest incentive for open discussion, the renewal of old, and establishment of new, friendships, all of which are important aspects of our scientific community. While it was not possible to publish all the papers presented at the Salamander Bay Symposium, I trust that those contained herei n will provide some indication of the overall quality and scope of the meeting. Peter Ghosh President C.T.S.A.N.Z.
Leukocyte Locomotion and Chemotaxis
1st International Conference on Leukocyte Locomotion and Chemotaxis, Gersau, May 16–21, 1982
AvProf. Dr. Hansuli U. Keller,Prof. Dr. Gerd O. Till
Häftad, Engelska, 2014
550 kr
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Ten years ago interest in leukocyte chemotaxis was restricted to a relatively small group of scientists whose interests were quite circumscribed. In the past decade both the number of workers and their publications has grown at some thing approaching an exponential rate and, more importantly, the field has gradually expanded to encompass a large number of diverse areas (mediators, receptors, cell effector mechanisms, regulatory factors, etc.). It is now apparent that leukocytes are particularly useful for studies of the locomotory behavior of all cell types and of mechanisms controlling cell movement and orientation. Chemotactic factors, once discovered as substan ces able to induce directional migration in leukocytes, are now recognized as potent stimulators of a variety of cell functions. Based on our knowledge in the field of basic research in leuko cyte chemotaxis, clinical observations in combination with ex perimental studies in vivo have provided new insights into the role of leukocyte-mediator interactions. The recognition that a specific interaction between chemotactic factor and leukocyte can lead to a multitude of cellular responses and products has opened up a broad area of study. The diversity of contributions to this volume based on a conference which was held in May 1982 in Gersau, Switzerland, reflects this development and demonstra tes that leukocyte chemotaxis continues to be an area of fasci nating and highly active research.
Therapeutic Strategies for Modulating the Inflammatory Diseases
AvB.M. Weichman,A.J. Mainm. fl.
Häftad, Engelska, 2012
567 kr
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The Eighth International Conference of the Inflammation Research Association was held on October 27 to 31, 1996 at Hershey Lodge and Convention Center in Hershey, Pennsylvania. As have others in this series, the conference focused on understanding the molecular mechanisms involved in acute and chronic inflammatory reactions as well as on therapeutic approaches to treating inflammatory diseases. One outstanding symposium focused on new drugs and was de signed as a forum for the dissemination of early clinical results on new anti-inflammatory agents. Other symposia spotlighted exciting advances being made in defining intracellular signaling path ways and the potential for future therapeutics that target cytokines and costimulatory pathways. This conference was characterized by a high level of participation by attendees, who represent both the academic and industrial sectors. It was gratifying to note that a large proportion of the attending scientists presented their latest findings during workshops, poster discussions, and pos ter se.ssions. This volume covers many of the highlights of the Eighth International Conference and should become a valuable resource for scientists involved in inflammation research and drug discovery.
Del 23 - Agents and Actions Supplements
Directions for New Anti-Asthma Drugs
AvS.R. O'Donnell,Persson
Häftad, Engelska, 2011
567 kr
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The last twenty years have witnessed enormous efforts by the pharmaceutical industry in the search for new drugs for the treatment of asthma. During this time, as a result of the efforts of asthma researchers in many disciplines, there has been an unprecedented increase in our knowledge about asthma as a disease and about the pharmacology of the existing anti-asthma drugs. This increase in knowledge should have generated information from which directions for future anti-asthma drug research and development might be predicted. Thus, we felt it was timely to invite a group of leading international pharmacologists to meet together on the occasion of the Xth International Congress of Pharmacology, being held for the first time in Australia (in Sydney August 23- 28th, 1987), for a satellite meeting to discuss the topic "New drugs for asthma". The proceedings of this small workshop are presented in this book. The meeting was unique in that leading pharmacologists from most of the pharmaceutical companies involved in the development of anti-asthma drugs were present. All participants, whether from the industry or from academia, were active researchers involved in providing the animal data and in carrying out human pharmacological studies, on new anti asthma drugs. Although the proceedings have been subtitled into "symptomatic" and "prophylactic" anti-asthma drugs for the purposes of presentation, this is not meant to pinpoint the idea that we believe such clear cut differences necessarily exist. In fact, they may not exist.
Basis for Variability of Response to Anti-Rheumatic Drugs
Proceeding of a Satellite Meeting of the Xth International Congress of Pharmacology held in Sydney, Australia August 20–22, 1987
AvP. Brooks
Häftad, Engelska, 2011
567 kr
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Since the rheumatic diseases are among the most prevalent of conditions, the anti-rheumatic drugs make up one of the largest groups of drugs prescribed. They vary from the non-steroidal anti-inflammatory drugs through to the complex imrnunomodulators. There are significant differences between these groups of drugs as regards their mechanism of action and within each spectrum of adverse reactions, yet there is also some overlap. class there are also subtle individual differences between the drugs despite a sharing of the basic mechanisms of action and range of side effects. It is this individual variation and, in particular, the individual reaction of the patient to the drug that we attempted to address at this symposium. The first symposium on Individual Variation in Response to Non Steroidal Anti-inflammatory Drugs was held at Leura, New South Wales, Australia as a satellite symposium to the XVI International Congress of Rheumatology in August, 1985. Following a successful meeting, proceedings of which were published in a supplement to Agents and Actions (Suppl. 17, 1986), it was decided to organise a second symposium as a satellite meeting of the International Congressof Pharmacology Meeting in Sydney, August, 1987. The meeting was held at the Manly Pacific and focused on variability in response to anti-rheumatic drugs in general rather than just concentrating on the non-steroidal drugs.
Vasodepressor Hormones in Hypertension: Prostaglandins and Kallikrein-Kinins
Prostaglandins and Kinins
AvG. Bönner
Häftad, Engelska, 2011
543 kr
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Under the generous chairmanship of Professor Dr. med. Werner Kaufmann we organized the international symposium on "VASODEPRESSOR HORMONES IN HYPERTENSION - PROSTAGLANDINS AND KININS" held in Nuremberg (FRG) as an official satellite symposium to the Meeting of the International Society of Hypertension 1986. This supplement brings together the most interesting papers presented at this symposium. In the past there were hundreds of publications in both fields, the prostaglandins and the kallikrein-kinins and there were a lot of information indic~ting that these two systems influence each other strongly. But it is not at all clear till today which role these two systems play in physiological or even pathophysio logical regulation of systemic blood pressure. So it was aim of this symposium to bring the scientists of these two fields together to discuss blood pressure regulation in respect of the prostaglandin and kallikrein-kinin system. The authors of the presented papers provided new findings, an overview of their own work, and their hypotheses in this field. We would like to thank the contributors for their excellent papers and scientific discussion. We pay particular credit to the Birkhauser Verlag AG, Basel, Switzerland, for their kind cooperation, and express particular thanks to Mrs Renate Wiesmann and Mrs Renate Cawello for writing the manuscripts. Our gratitude goes to Schwarz GmbH, Monheim (FRG) wi thout their sponsorship this symposium' and book would not have been possible. July, 1987 G. Bonner O. A. Carretero H. Kueppers J.
Inflammation: Mechanisms and their Impact on Therapy
Proceedings of an Advanced Teaching Course held in Rotterdam, November 1976
AvBonta,Thompsonm. fl.
Häftad, Engelska, 1977
542 kr
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This book comprises the proceedings of an view of the subject to an audience of clinicians. Advanced Teaching Course held in Rotterdam, The outcome is the present book. Due to the ex The Netherlands, on November 25-26, 1976. pert knowledge and didactic capacity of the con The history of this Course goes back to tributors, we hope the book will be of some use in 1972, when a small, loosely connected group of making research views accessible to those Dutch researchers, who were fascinated by in engaged in clinical practice. vestigating fundamental problems of inflam In organizing this Course we enjoyed the mation, felt the necessity of coming together support of the 'Gerrit Jan Mulder Foundation', from time to time to exchange ideas about their which aims to promote post-doctoral training in work. The desire for such informal gatherings led the Medical Faculty of the Erasmus University to the foundation of the Inflammation Section of Rotterdam. We are particularly obliged to Dr M.
Recent Developments in the Pharmacology of Inflammatory Mediators
Proceedings of an International Symposium held in Rotterdam, under auspices of the Dutch Society for Physiology and Pharmacology, in November 1976
AvBonta
Häftad, Engelska, 1977
542 kr
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In previous studies (1,2) we demonstrated the occurrence of a foetal protein after injury in the rat. This protein, behaving as an acute phase protein, proved to be already known as slow a2 glo- bulin (3), or reproduction associated protein (4). Furthermore it is identical to aM foetoprotein (also known as a2FP or aMFP (5) ). This protein is quite different to the well-known a-foetoprotein (aFP), occurring in man and other species during liver carcinoge- nesis and some other tumours. aMfoetoprotein (aMFP) is a glycoprotein with a mol.w. of 800.000. It is produced in the liver (6,2) and in the normal adult rat the plasma concentrations are rather low, about 0 - 40 ~g/ml. During fetal development the plasma level in the fetus is much higher (about 6000 ~g/ml), diminishing rapidly after birth to adult levels. But after injury (laparotomy, deep incision, partial hepatectomy followed by regeneration, BaS04 or CdS04 intraperitoneally), plasma levels increase fastly, reaching peak values of 1000 - 8000 ~g/ml after 24 - 48 hrs, declining thereafter gradually.Also very small lesions, as orbital punction, venasection, cannulations, small infections and so on, cause moderate rises of plasma levels up to 80 - 120 ~g/ml. During fetal stage the inflammatory reaction often lacks some of its characteristic features: oedema and infiltration of leucocytes are often rather scanty (7). Also is known that in exudates proteins occur, inhibiting experimen- tal inflammations (8,9).
Del 17 - Agents and Actions Supplements
Non-steroidal Anti-Inflammatory Drugs Basis for Variability in Response
16–18 May, 1985, at Leura, New South Wales, Australia
AvBrooks,Day
Häftad, Engelska, 1985
542 kr
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Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly prescribed groups of drugs in the community. This reflects the high frequency of rheumatic complaints but may in part be due to the relative non efficacy of these drugs. Since the introduction of ibuprofen, the first new NSAID to compete with aspirin, phenylbutazone and indomethacin, there has been a proliferation of new NSAIDs of differing chemical classes but an apparent similar spectrum of action. Despite the fact that these drugs are thought to work by an apparent common mechanism of action (suppression of prostaglandin synthetase activity) continued development of these drugs occurs. There exists at present a conflict between the pharmaceutical industry with its attempts to introduce new NSAIDs and drug regulatory authorities who are generally not convinced of the need for additional drugs of_ this class. The practising clinician regards a variety of NSAIDs as necessary to enable pain relief to be optimised.with minimal adverse effects. With respect to the dilemma of how many NSAIDs are really necessary surprisingly little convincing data is available to assist in resolving this issue. It was therefore decided to hold a satellite meeting to the XVIth International League Against Rheumatism Conference in May 1985.
Therapeutic Strategies for Modulating the Inflammatory Diseases
AvB.M. Weichman,A.J. Mainm. fl.
Inbunden, Engelska, 1997
566 kr
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The Eighth International Conference of the Inflammation Research Association was held on October 27 to 31, 1996 at Hershey Lodge and Convention Center in Hershey, Pennsylvania. As have others in this series, the conference focused on understanding the molecular mechanisms involved in acute and chronic inflammatory reactions as well as on therapeutic approaches to treating inflammatory diseases. One outstanding symposium focused on new drugs and was de signed as a forum for the dissemination of early clinical results on new anti-inflammatory agents. Other symposia spotlighted exciting advances being made in defining intracellular signaling path ways and the potential for future therapeutics that target cytokines and costimulatory pathways. This conference was characterized by a high level of participation by attendees, who represent both the academic and industrial sectors. It was gratifying to note that a large proportion of the attending scientists presented their latest findings during workshops, poster discussions, and pos ter se.ssions. This volume covers many of the highlights of the Eighth International Conference and should become a valuable resource for scientists involved in inflammation research and drug discovery.

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Agents and Actions Supplements – serie

Prostaglandins and Inflammation

Cologne Atherosclerosis Conference No. 2: Lipids

Prostaglandins in the Cardiovascular System

Novel Molecular Approaches to Anti-Inflammatory Therapy

Risk Factors for Adverse Drug Reactions — Epidemiological Approaches

New Perspectives in Histamine Research

Recent Progress on Kinins

New Drugs in Allergy and Asthma

Inflammation: Mechanisms and Therapeutics

Mediators in the Cardiovascular System: Regional Ischemia

Prostaglandins and Control of Vascular Smooth Muscle Cell Proliferation

Mediators in Airway Hyperreactivity

Update on Childhood Asthma

Proteases, Protease Inhibitors and Protease-Derived Peptides

Drugs in Inflammation

Joint Destruction in Arthritis and Osteoarthritis

PAF, Platelets, and Asthma

Inflammatory Indices in Chronic Bronchitis

Recent Advances in Connective Tissue Research

Leukocyte Locomotion and Chemotaxis

Therapeutic Strategies for Modulating the Inflammatory Diseases

Directions for New Anti-Asthma Drugs

Basis for Variability of Response to Anti-Rheumatic Drugs

Vasodepressor Hormones in Hypertension: Prostaglandins and Kallikrein-Kinins

Inflammation: Mechanisms and their Impact on Therapy

Recent Developments in the Pharmacology of Inflammatory Mediators

Non-steroidal Anti-Inflammatory Drugs Basis for Variability in Response

Therapeutic Strategies for Modulating the Inflammatory Diseases

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