Ettore Majorana International Science Series – serie

It has been widely recognized that the "new physics" results from a high energy collider are related to the detector capabilities, and that future detec- tors must solve the problems presented by the new environment. Vertex detectors, in particular, will have to sustain enormous rates, have a great resistance to radiation damage, while retaining good spatial accuracy. Promising technologies are emerging, and gaseous detectors are improving: this workshop was intended as a point of reference towards future detectors, with particular emphasis on experimental results achieved so far. We wish to thank the Ettore Majorana Center for the splendid hospitality in Erice; and the secretaries of the conference, R. Nania and G. Anzivino for their hard work in collecting and organizing these proceedings. F. Villa Stanford Linear Accelerator Center Stanford University v CONTENTS Tracking at 1 Te V A. Seiden ...1 B Physics at PEP and SLC A. Seiden ...19 The MARK II Vertex Detectors: Status and Prospects J. Jaros 37 The Mark-J Vertex Detector H. Anderhub et al., presented by M. Bourquin 71 A Modified Time Expansion Chamber as a Vertex Detector et al., presented by C. Del Papa ...95 G.Bari Operation of Multidrift Tubes with Dimethyl Ether R. BoucHer et al., Presented by F. SauH ...101 Results From the MACI Vertex Chamber H. N. Nelson ...115 Wire Chamber Aging and Wire Material M. Atac ...

The current state of the art of various aspects of micro emulsion systems is reflected in this volume. Major topics discussed include: general background on solubilized systems, phase diagrams and phase equi- libria, bicontinuous microemulsions, Winsor's phases, theories and models of complex self association structures, cry tical behaviour, phase tran- sitions in lyotropic liquid crystals. I hope that this book will serve its intended objective of reflecting our current understanding of microemulsions both in theory and practice, and that it will be useful to researchers, both novices as well as experts, as a valuable reference source. I feel indebted to the people of the Ettore Majorana Centre: the friendly atmosphere of the Erice centre provided a very effective environ- ment to enjoy the company of colleagues and friends during breaks and after sessions, and to discuss problems of mutual interest. The courtesy, efficiency and devotion of the secretarial and technical staff was also appreciated, and greatly contributed to make the Workshop a smoothly run- ning one.The Scientific Secretary Donatella Senatra Department of Physics University of Florence (Italy) v INTRODUCTION The decision to publish. in a more permanent form than heretofore. the Proceedings of the Workshop on "Progress in Microemulsion" of the Inter- national School of Quantum Electronics. which was held in Erice (Italy) from October 26 to November 1st. 1985. under the auspices of the "Ettore Majorana" Centre for Scientific Culture. will prove to be a sound one.

This book contains aseries of review papers related to the lectures given at the Third Course on Bioelectrochemistry held at Erice in November 1988, in the framework of the International School of Biophysics. The topics covered by this course, "Charge Separation Across Biomembranes, " deal with the electrochemical aspects of some basic phenomena in biological systems, such as transport of ions, ATP synthesis, formation and maintenance of ionic and protonic gradients. In the first part of the course some preliminary lectures introduce the students to the most basic phenomena and technical aspects of membrane bioelectrochemistry. The remaining part of the course is devoted to the description of a selected group of membrane-enzyme systems, capable of promoting, or exploiting, the processes of separation of electrically charged entities (electrons or ions) across the membrane barrier. These systems are systematically discussed both from a structural and functional point of view. The effort of the many distinguished lecturers who contributed to the course is aimed at offering a unifying treatement of the electrogenic systems operating in biological membranes, underlying the fundamental differences in the molecular mechanisms of charge translocation.

This Workshop was organized to bring once more tagether the scientists of the rather heterogeneaus field of exotic atoms. At present the main topic of the field seems to be the study of the atomic cascade. There are some who study it intentionally -Iet us call them cascadeurs -and others who think they investigate other features of the exotic atoms (like Coulomb capture, particle transfer, muon catalyzed fusion, chemical effects, fundamental properties, etc.) -users-while in fact they study some special consequences of the same atomic cascade. We decided to get cascadeurs and users discuss the problems of exotic atoms at wonderful Erice, at the 5th Course of the International School of Physics of Exotic Atoms. Our Workshop was quite successful, we have heard excellent talks from participants from a dozen countfies and most of them have prepared written contributions for this volume. The Organizers express their gratitude to all participants for their contributions, especially to David Measday for bis concluding remarks (not printed here) and to James Cohen for jumping in for Leonid Ponomarev who had to leave unexpectedly in the middle of the meeting. We greatly appreciate the enthusiastic help of Marianne Signer in every stage of the organization work. Am!, of course, the Workshop could not happen at all without the incredibly efficient organization by the Ettore Majorana Centre of Scientific Culture. Leopold M. Simons Dezsö Horvath Gabriele Torelli V CONTENTS OPENING ADDRESS . . . . . . . . . . . . . . . . . . . . . . . . . . xi . . . . . . .

Peter Gabriel Bergmann started his work on general relativity in 1936 when he moved from Prague to the Institute for Advanced Study in Princeton. Bergmann collaborated with Einstein in an attempt to provide a geometrical unified field theory of gravitation and electromagnetism. Within this program they wrote two articles together: A. Einstein and P. G. Bergmann, Ann. Math. 39, 685 (1938) ; and A. Einstein, V. Bargmann and P. G. Bergmann, Th. von Karman Anniversary Volume 212 (1941). The search for such a theory was intense in the ten years following the birth of general relativity. In recent years, some of the geometrical ideas proposed in these publications have proved essential in contemporary attempts towards the unification of all interactions including gravity, Kaluza-Klein type theories and supergravity theories. In 1942, Bergmann published the book "Introduction to the Theory of Relativity" which included a foreword by Albert Einstein. This book is a reference for the subject, either as a textbook for classroom use or for individual study. A second corrected and enlarged edition of the book was published in 1976. Einstein said in his foreword to the first edition: "Bergmann's book seems to me to satisfy a definite need. . . Much effort has gone into making this book logically and pedagogically satisfactory and Bergmann has spent many hours with me which were devoted to this end.

Every year between three and four hundred papers are published on the topic of insulin action. This extraordinary publication rate prevents any author from includ­ ing an exhaustive bibliography in any review or book. Perhaps due to this there is no single text that attempts to cover the effects and the mechanism of action of insulin. This book is such an attempt. I intend to present a review of the physiological effects of insulin, the pathology of defects in the action of insulin, and the current views on the mechanism of action of this hormone. I make no apology for the fact that the bibliography will not be extensive and that the amount of experimental detail and data discussed will be kept to a relevant minimum. This book is not intended for the expert in the field, but for the second- or third-year undergraduate and graduate student of medicine, biochemistry, physiology or related disciplines, and will be valuable as a reference source for research workers. The book is presented as a guide, a summary of the ideas and facts; it will present a reader with a foretaste of a fascinating and ever-changing field. I have attempted to be up-to-date with published research work. Any significant contributions to the field not included in the first draft have been added as footnotes. I assume a basic knowledge of the metabolic pathways of carbohydrates, fats and proteins.

This text covers the applications of nonlinear optics to optical processing in a range of areas including switching, computing and telecommunications. Each chapter presents the physics behind optical interactions between light and a range of materials and then examines the applications of the effects discussed. The book provides a comprehensive review of this expanding area and discusses the likely direction of future research. This book should be of interest to scientists and engineers involved in research and development in industry and the universities and postgraduate students in physics and electrical engineering.

Twenty years ago, researchers wishing to identify contaminated areas in aquatic environments generally took water samples, and analysed them badly (as we have since discovered) for a few "pollutants" which were of topical note at the time (and which could be quantified by the methods then available). Today, the use of aquatic organisms as biomonitors in preference to water analysis has become commonplace, and many national and interna­ tional programmes exist around the world involving such studies. We believe that this trend will continue, and have complete faith in the methodology (when it is employed correctly). We hope that the following text assists in some part in attaining this goal, such that the quality of our most basic global resource -water - is adequately protected in the future. DAVE PHILLIPS, PHIL RAINBOW England, March 1992 vii Acknowledgements Our thanks for contributions to this book are due to several individuals and groups, for varying reasons. Firstly, a co-authored book is always a triumph, and we trust that the following text is an acceptable compromise of the views of two individual authors, on a complex and developing topic. Secondly, many of the ideas herein have crystallised over the last two decades as the field has grown, and we are individually and collectively grateful to a number of researchers for their insight and assistance.

Ecotoxicology is a relatively new scientific discipline. Indeed, it might be argued that it is only during the last 5-10 years that it has come to merit being regarded as a true science, rather than a collection of procedures for protecting the environment through management and monitoring of pollutant discharges into the environment. The term 'ecotoxicology' was first coined in the late sixties by Prof. Truhaut, a toxicologist who had the vision to recognize the importance of investigating the fate and effects of chemicals in ecosystems. At that time, ecotoxicology was considered a sub-discipline of medical toxicology. Subsequently, several attempts have been made to portray ecotoxicology in a more realistic light. Notably, both Moriarty (1988) and F. Ramade (1987) emphasized in their books the broad basis of ecotoxicology, encompassing chemical and radiation effects on all components of ecosystems. In doing so, they and others have shifted concern from direct chemical toxicity to humans, to the far more subtle effects that pollutant chemicals exert on natural biota. Such effects potentially threaten the existence of all life on earth. Although I have identified the sixties as the era when ecotoxicology was first conceived as a coherent subject area, it is important to acknowledge that studies that would now be regarded as ecotoxicological are much older.

Ecotoxicology is a relatively new scientific discipline. Indeed, it might be argued that it is only during the last 5-10 years that it has come to merit being regarded as a true science, rather than a collection of procedures for protecting the environment through management and monitoring of pollutant discharges into the environment. The term 'ecotoxicology' was first coined in the late sixties by Prof. Truhaut, a toxicologist who had the vision to recognize the importance of investigating the fate and effects of chemicals in ecosystems. At that time, ecotoxicology was considered a sub-discipline of medical toxicology. Subsequently, several attempts have been made to portray ecotoxicology in a more realistic light. Notably, both Moriarty (1988) and F. Ramade (1987) emphasized in their books the broad basis of ecotoxicology, encompassing chemical and radiation effects on all components of ecosystems. In doing so, they and others have shifted concern from direct chemical toxicity to humans, to the far more subtle effects that pollutant chemicals exert on natural biota. Such effects potentially threaten the existence of all life on earth. Although I have identified the sixties as the era when ecotoxicology was first conceived as a coherent subject area, it is important to acknowledge that studies that would now be regarded as ecotoxicological are much older.

Based on the Lectures given during the Ispra-Course held at the Centro de Formacao Tecnica, Lisbon, Portugal, October 23-27, 1989, in collaboration with the Laboratorio Nacional de Engenharia e Tecnologia

To the classical forces of migration such as poverty, oppression and war, yet another is being added: globalization. The trend toward globalization has created new opportunities for trade and investment. These have had positive implications for economic growth and living standards. However, they also confront developed and less developed countries (LCDs) with difficult policy choices. Developed Countries (DCs) have to find a compromise between competitiveness and high labour costs, and between trade liberalization and immigration controls. LCDs have to decide whether to export labour or goods, and to accept foreign resources for development rather than migration. While, in the literature, the impact of globalization has been largely studied from specialist perspectives, this volume offers a comprehensive view of the issue.In this work there is explaination of the welfare implications of export of goods and labour from LCDs to the DCs from the perspective of both international and labour economics; shedding of light on the possible relationship between foreign direct investment and migration; an offering of a better understanding of the experiences of Asian, Latin American and African countries with exporting goods or labour; and a discussion of the different policy responses to the globalization of labour markets in the European Union, East and South-East Asia and Latin America, while being aware of inter-country variations within these regions.

The second course of the International School on Physics with Low Energy Antiprotons was held in Erice, Sicily at the Ettore Majorana Centre for Scientific Culture, from May 20 to May 31, 1987. The School is dedicated to physics accessible to experiments using low energy antiprotons, especially in view of operation of the LEAR facility at CERN with the upgraded antiproton source AAC (Antiproton Accumulator AA and Antiproton Collector ACOL). The first course in 1986 covered topics related to fundamental symmetries. This book contains the proceedings of the second course which focused on spectroscopy of light and heavy quarks. These proceedings contain both the tutorial lectures and contri­ butions presented by participants during the School. The papers are organized in four sections: The first section includes theoretical reviews. Section II contains experimental reviews and covers the results in meson spectroscopy from DM2, MARK III, GAMS and n-WA76. Section III presents the new meson spectroscopy experiments in pre­ paration at CERN and Fermilab: Crystal Barrel, OBELIX, Jetset and E760. Section IV is dedicated to LEAR and to future facilities where meson spectroscopy would be a principal component of the physics programme. We should like to thank Dr. Alberto Gabriele and the staff of the Ettore Majorana Centre who provided for a smooth running of the School and a very pleasant stay. We are particularly grateful to Mrs. Anne Marie Bugge for her crucial help during the preparation and running of the School and for the editing of these Proceedings.

In recent years, a new field of nuclear research has been opened through the possibility of studying nuclei wi\h very large values of angular momentum, temperature, pressure and number of particles. This development has been closely associated with heavy ion reactions, since collisions between two heavy nuclei are especially effective in producing metastable compound systems with large angular momentum, and in transferring energy which is distributed over the whole nuclear volume. Under the strain of temperature and of the Coriolis and centrifugal forces, the nucleus displays structural changes which can be interpreted in terms of pairing and shape phase transit­ ions. This was the subject of the lectures of J. D. Garrett, P. J. Twin and S. Levit. While the rotational motion is, at zero temperature un­ damped, the width of giant resonances indicate that the nucleus only oscillates through few periods before the motion is damp­ ed by particle decay, and through coupling to the compound nucleus. Temperature and angular momentum influence in an im­ portant way the properties of both giant resonances and rotatio­ nal motion. These subjects were developed by K. Snover, and by P. F. Bortignon and R. A. Broglia, as well as by A. Bracco, A. Dellafiore and F. Matera.

This book presents an account of the course "Spectroscopy of Solid-State Laser-Type Materials" held in Erice, Italy, from June 16 to 30, 1985. This meeting was organized by the International School of Atomic and Molecular Spectroscopy of the "Ettore Majorana" Centre for Scientific Culture. The objective of the course was to present and examine the recent advances in spectroscopy and theoretical modelling relevant to the interpretation of luminescence and laser phenomena in several classes of solid-state materials. The available solid-state matrices (e.g. halides, oxides, glasses, semiconductors) and the full range of possible activators (transition ions, rare earth ions, post-transition ions, actinides, color centres) were considered. By bringing together specialists in the fields of solid-state luminescence and of solid-state laser materials, this course provided a much-needed forum for the critical . assessment of past developments in the R&D of solid-state lasers. Additional objectives of the meeting were to identify new classes of host/activator systems that show promise of laser operation; to alert researchers in solid-state luminescence to current technological needs for solid-state tunable lasers operating in the visible and infrared spectral regions; and generally to provide the scientific background for advanced work in solid state lasers. A total of 71 participants came from 54 laboratories and 21 nations (Austria, Belgium, Canada, F.R. of Germany, France, Greece, Ireland, Israel, Italy, the Netherlands, P.R. of China, Poland, Rumania, Sweden, Switzerland, South Korea, Spain, Turkey, United Kingdom, U.S.A. and U.S.S.R.).

This book contains the lectures of the second course devoted to bioelectro­ chemistry, held within the framework of the International School of Biophysics. In this course another very large field of bioelectrochemistry, i. e. the field of Membrane Phenomena, was considered, which itself consists of several different, but yet related subfields. Here again, it can be easily stated that it is impossible to give a complete and detailed picture of all membrane phenomena of biological interest in a short course of about one and half week. Therefore the same philosophy, as the one of the first course, was followed, to select a series of lectures at postgraduate level, giving a synthesis of several membrane phenomena chosen among the most'important ones. These lectures should show the large variety of membrane-regulated events occurring in living bodies, and serve as sound interdisciplinary basis to start a special­ ized study of biological phenomena, for which the investigation using the dual approach, physico-chemical and biological, is unavoidable. Since, as already mentioned, it was impossible to exhaust, even roughly, is a short course like this, the presentation and introductory treatment of the extremely large variety of membrane phenomena, it can be expected that the third course will continue the subject of membrane phenomena deepening some ones presented in this course and introducing some new ones. vii CONTENTS Symbols and acronyms IX Opening address G. MILAZZO 1 Structure of biological membranes and of their models I J . A. HAYWARD et al.

For ten days at the end of September, 1987, a group of about 75 scientists from 21 different countries gathered in a restored monastery on a 750 meter high piece of rock jutting out of the Mediterranean Sea to discuss the simulation of the transport of electrons and photons using Monte Carlo techniques. When we first had the idea for this meeting, Ralph Nelson, who had organized a previous course at the "Ettore Majorana" Centre for Scientific Culture, suggested that Erice would be the ideal place for such a meeting. Nahum, Nelson and Rogers became Co-Directors of the Course, with the help of Alessandro Rindi, the Director of the School of Radiation Damage and Protection, and Professor Antonino Zichichi, Director of the "Ettore Majorana" Centre. The course was an outstanding success, both scientifically and socially, and those at the meeting will carry the marks of having attended, both intellectually and on a personal level where many friendships were made. The scientific content of the course was at a very high caliber, both because of the hard work done by all the lecturers in preparing their lectures (e. g. , complete copies of each lecture were available at the beginning of the course) and because of the high quality of the "students", many of whom were accomplished experts in the field. The outstanding facilities of the Centre contributed greatly to the success. This volume contains the formal record of the course lectures.

Every year between three and four hundred papers are published on the topic of insulin action. This extraordinary publication rate prevents any author from includ­ ing an exhaustive bibliography in any review or book. Perhaps due to this there is no single text that attempts to cover the effects and the mechanism of action of insulin. This book is such an attempt. I intend to present a review of the physiological effects of insulin, the pathology of defects in the action of insulin, and the current views on the mechanism of action of this hormone. I make no apology for the fact that the bibliography will not be extensive and that the amount of experimental detail and data discussed will be kept to a relevant minimum. This book is not intended for the expert in the field, but for the second- or third-year undergraduate and graduate student of medicine, biochemistry, physiology or related disciplines, and will be valuable as a reference source for research workers. The book is presented as a guide, a summary of the ideas and facts; it will present a reader with a foretaste of a fascinating and ever-changing field. I have attempted to be up-to-date with published research work. Any significant contributions to the field not included in the first draft have been added as footnotes. I assume a basic knowledge of the metabolic pathways of carbohydrates, fats and proteins.

Endotoxins are constituents of all gram negative bacteria, as well as many other microorganisms. Since their original discovery and study at the beginning and middle parts of this century, many investigations have been performed concerning their immunochemistry and physicochemistry, as well as their pharmacologic activities and physiologic effects on the host. It became widely recognized during the beginning of this century that the pyrogenicity of many microbial infections may be associated with endotoxins. Furthermore, some 80 years ago, attempts were begun to "treat" a variety of illnesses including neoplasia, with such "pyrogens", Le. , bacterial endo­ toxins. Inconclusive results were observed including some detrimental ones as well as, in some cases, beneficial ones. It became widely accepted that during infections with many gram negative organisms the fever occurring in patients, as well as many of the untoward pathophysiological effects of the infections, seemed to be due to the endotoxin the bacteria contained or released. In this regard, septic shock has been studied in detail by many clinicians, physiologists and pharmacologists and attempts have been made to relate the devastating effects of infection on metabolic and physiologic alterations caused by endotoxins. Recently, however, many beneficial effects of endotoxin have also been studied.

This book is based on the papers delivered at an International Workshop on Multiple Sclerosis held in Erice, Italy from 29th August to 1st September 1983. The Meeting was organized with great efficiency in the delightful setting of the Centro di Cultura Scientifica Ettore Mahorana, by its Director, Antonino Zichichi, and was directed by the Editors of the Proceedings and by Professor C. Alvisi of the University of Bologna. The emphasis was deliberately on the contributions of laboratory science to the understanding of mUltiple sclerosis, its etiology, pathogenesis, diagnosis and treatment. Where so much is unknown, disagreement was expected and indeed welcome, and it is regrettable that it was not possible to publish verbatim the often animated and always interesting discussion. Differing views on the relevance of experimental allergic encephalomyelitis to multiple sclerosis were expressed by Dr. Wisniewski, Professor Seitelberger and Professor Alvord, who graphi- cally illustrated his changing beliefs over the years. Professor Seitelberger laid much greater emphasis on remyelination in remission in mUltiple sclerosis than had previously been the accepted view.The disorder of both humoral and cellular immunity in multiple scler- osis was discussed by Dr. Roos and Professor Link. Dr. Gilden described how recombinative techniques might be applied to the detec- tion of a virus in multiple sclerosis. The continued inability to detect any antigen to match the oligoclonal IgG bands in the CSF in multiple sclerosis patients was disappointing and there was an increasing tendency to regard the bands as "nonsense" antibodies.

The 50-year history of weak interaction since Fermi's pro­ posal of this coupling has been marked with striking direct inter­ plays between experimental results and theoretical understanding, e.g. the discoveries of neutrinos, parity violation, and CP vio­ lation. The recent discoveries of the quark hierarchy, the charm and the beauty, and the intermediate vector bosons W± and ZO have truly made a splendid page in the history of particle physics. It is the purpose of this conference to discuss the questions of quark and lepton generations and mixing, their relations to CP violation, and to ask the questions about what are inside the quarks and the leptons in view of the present and future exper­ imental situation. Dr. Ling-Lie Chau Brookhaven National Laboratory Upton, New York vii ACKNOWLEDGMENTS I would like to thank all the Advisory and Organizing Committee members for their advice and suggestions during the organization of the conference. The running of the conference could not have gone so smoothly without the help of many participants, I sincerely thank: L. Becker, F.J. Botella, S. Gentile, P. Le Comte, M.E. Machacek, L. Lanceri, W.M. Morse, F.J. Olness, Y.-X. Pham, G. Poulard, K.J. Sliwa, and J.N. Webb.

The proceedings of this volume represent a record of a meeting in the Ettore Majorana center in Erice, Sicily from 16-24 July, 1983. This was the fifth course of the International School of Urology and Nephrology, the fourth in a series of meetings devoted to different aspects of Urological Oncology. Speakers and delegates came from nearly every part of the world and contributed to a detailed analysis of the current state of knowledge of tumors of the testicle and to the development of knowledge of cancer of the bladder, prostate and kidney. Previous volumes resulting from this series of meetings have been well received and the Editors hope that the reader may find the record of this meeting equally attractive. We are indebted to the Department of Medical Illustration, St. James's University Hospital, for their kindness in producing several of the illustrations in this book. The editors are very grateful to Dr. Cavallo of Palermo for the major part which he has played in preparing the index. M. Pavone-Macaluso P.H. Smith M.A. Bagshaw v CONTENTS I TUMORS OF THE TESTIS CLASSIFICATION, PATHOLOGY, AETIOLOGY, RESEARCH Pre-treatment Classification of Tumors of the Testis 1 G. Pizzocaro, A. Milani and M. Pasi Histopathological Classification of Testicular Tumors 9 F. Mostofi and I.A. Sesterhenn Rare Tumors of Testes and Adnexal Tumors 29 F. Mostofi and C.J. Davis, Jr.

This volume contains the Proceedings of a two-week course on "Laser Applications to Biology and Medicine" held from September 4 to 16, 1983 in Erice, Italy. This is the 10th annual course of the International School of Quantum Electronics organized under the auspices of the "E. Majorana" Center for Scientific Culture. ,Among the possible approaches to a course on Laser Applications to Biology and Medicine, the one which emphasizes the scientific and technological aspects of the advanced laser techniques when applied to laboratory and clinical tests has been chosen. In fact, it reflects the new policy of the School to stress the advanced scien­ tific and technological achievements in the field of Quantum Elec­ tronics. Accordingly, the Course has given the broadest information on the ultimate performances already achieved and the perspectives of their applications. Because of the great variety of applications of laser in biology, medicine, chemistry, engineering and related branches of science, this school addressed a subject of interdisciplinary interest. The formal sessions have been balanced between tutorial presentations and lectures focusing on unsolved problems and future directions. In addition, wide time has been provided for the par­ ticipants to meet together informally for additional discussions on the forefront of current work. Therefore the character of the Course was a blend of current research and tutorial reviews.

This volume is a report of the proceedings of the Second International Urological Course held in the Ettore Majorana Centre in Erice, Sicily from the 4-8 November 1978. The meeting was sponsored by the Urological Group of the EORTC (European Organisation for Research in the Treatment of Cancer), the WHO Collaborating Centre for Bladder Cancer, the European Urological Association, the Italian Research Council (CNR) , Italian League against Tumours, Italian Government and Regional Sicilian Government. Contributions were accepted on the understanding that the editors could make certain changes leading towards a uniformity of style but accepting as a priority the importance of early publication, if necessary at the expense of stylistic perfection. Editorial notes have been inserted at infrequent intervals, sometimes to summarise discussions and at others in an attempt to clarify certain issues or to highlight conflicting opinions. Although the work has been divided amongst the editors and co­ editors it is only proper to acknowledge that the major role in collating and in correcting much of the material has fallen on Mrs MAske who has also typed the manuscript. We should also like to acknowledge the kindness of the Yorkshire Regional Cancer Organisation who allowed Mrs Aske to devote much of her time to this work, Miss S Barrowby who has also given considerable secretarial assistance and the Department of Medical Photography, st James's University Hospital, Leeds whose staff are responsible for many of the illustrations.

Physicists actively engaged in advanced research should be en- couraged to discuss results and deepen their theoretical understand- ing of the data. It is practically impossible nowadays to achieve the goal of the old times when small groups of scientists had the privilege of debating their ideas and the details of their experi- ments in an informal and friendly way. Conferences are now too wide in scientific coverage and, in consequence, there are often too many participants. The Highly Specialized Seminars of the Ettore Majorana Centre for Scientific Culture are intended to provide such a forum for scientists of outstanding reputation in their fields to exchange information. This volume deals with one of the most interesting topics in subnuclear physics, and Professor Giuliano Preparata is one of the world's leaders in the field. This volume contains the most recent results on the study of deep inelastic phenomena, using neutrinos, muons and electrons against nucleons, and (e+e-) interactions. It represents our best knowledge of the field as given by some of the most distinguished world experts in the theoretical and experimental domain.Antonino Zichichi, Director Ettore Majorana Centre for Scientific Culture v PREFACE In March 1979, about 50 physicists gathered in Erice to parti- cipate in the Fourth Highly Specialized Seminar on "Probing Hadrons with Leptons".

The Third International School on Energetics was devoted to the subject of Energy for the Year 2000. By this title we hoped to avoid discussion of such matters as the role of OPEC in raising oil prices. In one sense, therefore, our task was made easier; we could merely look into our crystal balls. The choice of lecturers was made with the idea that no reason­ able source of energy can be overlooked. We omitted detailed lectures on oil and natural gas because we took it as a given fact that we would continue to use as much of these fuels as we can get at a reasonable price. To give us an overview we started the School by discussing U.S. energy policy and possible U.S. energy scenarios. As might be ex­ pected, there was some disagreement about the current energy program in the U.S., but little disagreement about the facts presented.

This volume constitutes the Proceedings of a Europhysics Study Conference held in Erice, Sicily from March 17 to 24, 1980. The objective of the meeting was to bring together practitioners of two different approaches to the unification of the fundamental par­ ticle interactions: supersymmetry and supergravity on the one hand, and grand unified gauge theories on the other hand. The hope was that exposure to each others' ideas and problems would at least aid mutual comprehension, and might start people thinking how to develop a synthesis of the two approaches which could avoid their individual shortcomings. It is not clear to us how successful the conference was in achieving these objectives. On the one hand many important ad­ vances in supersymmetric theories were reported which were primarily of a technical nature, while some interesting attempts to probe the phenomenological consequences of supersymmetry and supergravity were also presented. On the other hand there was considerable in­ terest in phenomenological aspects of grand unified theories such as proton decay, neutrino masses and oscillations, and links with cosmology. There was also some work on model-building but rela­ tively few purely technical advances. A few speakers tried to build bridges between the formalism of supersymmetry or supergravity and the phenomenologically successful gauge theories of elementary par­ ticle interactions.

These are the proceedings of the Workshop on Quantum Logic held in Erice (Sicily), December 2 - 9, 1979, at the Ettore Hajorana Centre for Scientific Culture. A conference of this sort was originally proposed by Giuliano Toraldo di Francia, who suggested the idea to Antonino Zichichi, and thus laid the foundation for the Workshop. To both of them we express our appreciation and thanks, also on behalf of the other participants, for having made this conference possible. There were approximately fifty participants; their names and institutions are listed in the text. Quantum logic, which has now a history of some forty or more years, has seen remarkable growth during the sixties and seventies. The papers in the present volume presuppose, by and large, some acquaintance with the elements of the subject. These may be found in the well-known books by J.H. Jauch (Foundations of Quantum Hechanics; Reading, 1968), V.S. Varadarajan (Geometry of Quantum Theory: Princeton, 1968), and C. Piron (Foundations of Quantum Theory; New York, 1976). The initial program for the conference listed about twenty-five invited papers. But in the context of a very active and qualified attendance, other contributions were offered. This volume contains all of them. The program listed six main topics: I. Classification or different areas of quantum logic, and open problems. II. Comparison and unification of different approaches to quantum theories; problems of interpretation. III. Formal quantum logic; axiomatics. IV. Hodal interpretations of quantum logic. v vi FOREWORD V. Quantum set theory.