Innovations in Cognitive Neuroscience – serie

The interest in ‘biomarkers’ seen across a spectrum of biomedical disciplines reflects the rise of molecular biology and genetics.  A host of ‘omics’ disciplines in addition to genomics, marked by multidimensional data and complex analyses, and enabled by bioinformatics, have pushed the trajectory of biomarker development even further.  They have also made more tractable the complex mappings of genotypes to phenotypes – genome-to-phenome mapping – to which the concept of a biomarker is central.Genomic investigations of the brain are beginning to reveal spectacular associations between genes and neural systems.  Neural and cognitive phenomics are considered a necessary complement to genomics of the brain.  Other major omics developments such as connectomics, the comprehensive mapping of neurons and neural networks, are heralding brain maps of unprecedented detail.  Such developments are defining a new era of brain science.  And in this new research environment, neural systems and cognitive operations are pressed for new kinds of definitions – that facilitate brain-behavioral alignment in an omics operating environment.  This volume explores the topic of markers framed around the constructs of cognitive and neural systems.  ‘Neurophenotype’ is a term adopted to describe a neural or cognitive marker that can be scientifically described within an associative framework – and while the genome-to-phenome framework is the most recognized of these, epigenetics and non-gene-regulated neural dynamics also suggest other frameworks.  In either case, the term neurophenotype defines operational constructs of brain-behavioral domains that serve the integration of these domains with neuroscientific and omics models of the brain.  The topic is critically important to psychiatry and neuropsychology:  Neurophenotypes offer a ‘format’ and a ‘language’ by which psychiatry and neuropsychology can be in step with the brain sciences.  They also bring a new challenge to the clinical neurosciences in terms of construct validation and refinement. Topics covered in the volume include:Brain and cognition in the omics eraPhenomics, connectomics, and Research Domain CriteriaCircuit-based neurophenotypes, and complications posed by non-gene regulated factorsThe legacy of the endophenotype concept – its utility and limitationsVarious potential neurophenotypes of relevance to clinical neuroscience, including ResponseInhibition, Fear Conditioning and Extinction, Error Processing, Reward Dependence and  Reward Deficiency, Face Perception, and Language PhenotypesDynamic (electrophysiological) and computational neurophenotypesThe challenge of a cultural shift for psychiatry and neuropsychology  The volume may be especially relevant to researchers and clinical practitioners in psychiatry and neuropsychology and to cognitive neuroscientists interested in the intersection of neuroscience with genomics, phenomics and other omics disciplines.

This important volume brings together significant findings on the neural bases of spoken language –its processing, use, and organization, including its phylogenetic roots. Employing a potent mix of conceptual and neuroimaging-based approaches, contributors delve deeply into specialized structures of the speech system, locating sensory and cognitive mechanisms involved in listening and comprehension, grasping meanings and storing memories. The novel perspectives revise familiar models by tracing linguistic interactions within and between neural systems, homing in on the brain’s semantic network, exploring the neuroscience behind bilingualism and multilingual fluency, and even making a compelling case for a more nuanced participation of the motor system in speech. From these advances, readers have a more three-dimensional picture of the brain—its functional epicenters, its connections, and the whole—as the seat of language in both wellness and disorders.Included in the topics:·         The interaction between storage and computation in morphosyntactic processing.·         The role of language in structure-dependent cognition.·         Multisensory integration in speech processing: neural mechanisms of cross-modal after-effect.·         A neurocognitive view of the bilingual brain.·         Causal modeling: methods and their application to speech and language.·         A word in the hand: the gestural origins of language. Neural Mechanisms of Language presents a sophisticated mix of detail and creative approaches to understanding brain structure and function, giving neuropsychologists, cognitive neuroscientists, developmental psychologists, cognitive psychologists, and speech/language pathologists new windows onto the research shaping their respective fields.

The interest in ‘biomarkers’ seen across a spectrum of biomedical disciplines reflects the rise of molecular biology and genetics.  A host of ‘omics’ disciplines in addition to genomics, marked by multidimensional data and complex analyses, and enabled by bioinformatics, have pushed the trajectory of biomarker development even further.  They have also made more tractable the complex mappings of genotypes to phenotypes – genome-to-phenome mapping – to which the concept of a biomarker is central.Genomic investigations of the brain are beginning to reveal spectacular associations between genes and neural systems.  Neural and cognitive phenomics are considered a necessary complement to genomics of the brain.  Other major omics developments such as connectomics, the comprehensive mapping of neurons and neural networks, are heralding brain maps of unprecedented detail.  Such developments are defining a new era of brain science.  And in this new research environment, neural systems and cognitive operations are pressed for new kinds of definitions – that facilitate brain-behavioral alignment in an omics operating environment.  This volume explores the topic of markers framed around the constructs of cognitive and neural systems.  ‘Neurophenotype’ is a term adopted to describe a neural or cognitive marker that can be scientifically described within an associative framework – and while the genome-to-phenome framework is the most recognized of these, epigenetics and non-gene-regulated neural dynamics also suggest other frameworks.  In either case, the term neurophenotype defines operational constructs of brain-behavioral domains that serve the integration of these domains with neuroscientific and omics models of the brain.  The topic is critically important to psychiatry and neuropsychology:  Neurophenotypes offer a ‘format’ and a ‘language’ by which psychiatry and neuropsychology can be in step with the brain sciences.  They also bring a new challenge to the clinical neurosciences in terms of construct validation and refinement. Topics covered in the volume include:Brain and cognition in the omics eraPhenomics, connectomics, and Research Domain CriteriaCircuit-based neurophenotypes, and complications posed by non-gene regulated factorsThe legacy of the endophenotype concept – its utility and limitationsVarious potential neurophenotypes of relevance to clinical neuroscience, including ResponseInhibition, Fear Conditioning and Extinction, Error Processing, Reward Dependence and  Reward Deficiency, Face Perception, and Language PhenotypesDynamic (electrophysiological) and computational neurophenotypesThe challenge of a cultural shift for psychiatry and neuropsychology  The volume may be especially relevant to researchers and clinical practitioners in psychiatry and neuropsychology and to cognitive neuroscientists interested in the intersection of neuroscience with genomics, phenomics and other omics disciplines.

This important volume brings together significant findings on the neural bases of spoken language –its processing, use, and organization, including its phylogenetic roots. Employing a potent mix of conceptual and neuroimaging-based approaches, contributors delve deeply into specialized structures of the speech system, locating sensory and cognitive mechanisms involved in listening and comprehension, grasping meanings and storing memories. The novel perspectives revise familiar models by tracing linguistic interactions within and between neural systems, homing in on the brain’s semantic network, exploring the neuroscience behind bilingualism and multilingual fluency, and even making a compelling case for a more nuanced participation of the motor system in speech. From these advances, readers have a more three-dimensional picture of the brain—its functional epicenters, its connections, and the whole—as the seat of language in both wellness and disorders.Included in the topics:·         The interaction between storage and computation in morphosyntactic processing.·         The role of language in structure-dependent cognition.·         Multisensory integration in speech processing: neural mechanisms of cross-modal after-effect.·         A neurocognitive view of the bilingual brain.·         Causal modeling: methods and their application to speech and language.·         A word in the hand: the gestural origins of language. Neural Mechanisms of Language presents a sophisticated mix of detail and creative approaches to understanding brain structure and function, giving neuropsychologists, cognitive neuroscientists, developmental psychologists, cognitive psychologists, and speech/language pathologists new windows onto the research shaping their respective fields.

This groundbreaking text takes current knowledge of the basal ganglia far from well-known motor-based models to a more inclusive understanding of deep-brain structure and function. Synthesizing diverse perspectives from across the brain-behavioral sciences, it tours the neuroanatomy and circuitry of the basal ganglia, linking their organization to their controlling functions in core cognitive, behavioral, and motor areas, both normative and disordered. Interactions between the basal ganglia and major structures of the brain are identified in their contributions to a diverse range of processes, from language processing to decision-making, emotion to visual perception, motivation to intent. And the basal ganglia are intimately involved in the mechanisms of dysfunction, as evinced by chapters on dyskinesia, Parkinson’s disease, neuropsychiatric conditions, and addictions.  Included in the coverage:    Limbic-basal ganglia circuits:parallel and integrative aspects.Dopamine and its actions in the basal ganglia system.Cerebellar-basal ganglia interactions.The basal ganglia contribution to controlled and automatic processing.The basal ganglia and decision making in neuropsychiatric disorders.The circuitry underlying the reinstatement of cocaine seeking:                        modulation by deep brain stimulation.The basal ganglia and hierarchical control in voluntary behavior.  Its breadth and depth of scholarship and data should make The Basal Ganglia a work of great interest to cognitive psychologists and neuroscientists, neuropsychologists, neurologists, neuropsychiatrists, and speech-language pathologists.