Molecular Medicine And Medicinal Chemistry - Böcker
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7 produkter
7 produkter
Del 2 - Molecular Medicine And Medicinal Chemistry
Merkel Cell Carcinoma: A Multidisciplinary Approach
Inbunden, Engelska, 2010
1 690 kr
Skickas inom 5-8 vardagar
Merkel cell carcinoma is an uncommon but not rare aggressive cutaneous malignancy. It has many similarities to melanoma, particularly in the need for aggressive multidisciplinary treatment, but far less is known about this disease by most practicing physicians. This book summarizes all of the existing knowledge about Merkel cell carcinoma and provides a much-needed perspective on future opportunities for diagnostic and therapeutic advances. It offers practical “how to” advice on diagnosis, treatment and follow-up, and also insight into how to establish a multidisciplinary Merkel cell carcinoma clinic. In addition, it will serve as a unique resource for trainees (medical students, residents and fellows) as well as for Merkel cell carcinoma patients and their advocates and caregivers. There is currently no such textbook, even an outdated one, covering this topic.
Del 1 - Molecular Medicine And Medicinal Chemistry
Micrornas In Development And Cancer
Inbunden, Engelska, 2010
1 486 kr
Skickas inom 5-8 vardagar
MicroRNAs have recently emerged as key regulators of gene expression during development and are frequently misexpressed in human disease states, in particular cancer. These 22-nucleotide-long transcripts act to promote or repress cell proliferation, migration and apoptosis during development, all of which are processes that go awry in cancer. Thus, microRNAs have the ability to behave like oncogenes or tumor suppressors. In addition, their small size and molecular properties make them amenable as targets and therapeutics in cancer treatment. This book goes into detail on how microRNAs represent a paradigm shift in thinking about gene regulation during development and disease, and provide the oncologist with a potentially powerful new battery of agents to diagnose and treat cancer.
Del 5 - Molecular Medicine And Medicinal Chemistry
Molecular Exploitation Of Apoptosis Pathways In Prostate Cancer
Inbunden, Engelska, 2012
1 307 kr
Skickas inom 5-8 vardagar
This book focuses on the functional significance of targeting apoptosis for the treatment of prostate cancer. New concepts on the challenges relating to the development of resistance by androgen-independent tumors are introduced, in terms of the contribution of anoikis and cross-talk of androgens with key growth factor signaling pathways. This volume also provides insightful discussion on the exploitation of the apoptotic and angiogenic synergism towards complete eradication of prostate tumors. Last but not least, it includes reflections on the drug development challenge based on the analysis of data from existing clinical trials.
Del 3 - Molecular Medicine And Medicinal Chemistry
Dna Deamination And The Immune System: Aid In Health And Disease
Inbunden, Engelska, 2010
1 269 kr
Skickas inom 5-8 vardagar
This book covers the current understanding of the role of activation-induced cytidine deaminase (AID) in the generation of antibody response to antigenic challenge. Since the discovery of AID, and the genetic demonstration of its role in somatic hypermutation and class-switch recombination of antibody genes, much has been learned about the biochemistry of this enzyme. However, some key questions remain hotly contested, such as: how does this enzyme get to the antibody locus leaving the rest of the genome intact, and why are DNA repair pathways which normally repair deamination events co-opted into actually fixing mutations into the genome? These questions, among others, will be addressed in this monograph from various perspectives. Being leading experts in their respective fields, the contributors of this highly valued title summarize current research in the field of AID and put forth hypotheses in order to provide a platform for future experiments.
2 410 kr
Skickas inom 3-6 vardagar
Monoclonal antibodies have become important treatments for cancer, inflammation and a wide range of other diseases, representing an increasing share of the most successful pharmaceutical markets. The technologies to discover these drugs have been developed by select centers of excellence in industry and academia, and are continually being fine tuned in the race to identify the best antibody-based drug candidates and accelerate their paths to patients. The objective of this volume is to provide a series of guides to those evaluating and preparing to enter particular areas within the field and to offer specialized perspectives to established researchers. The chapters set into context the significance of key developments and important considerations for selecting different approaches, such as antibody humanization, isotype selection, lead candidate selection criteria and protein production. All contributors to this work are experts in their fields, and many have played pivotal roles in the creation of these technologies.
Del 6 - Molecular Medicine And Medicinal Chemistry
Fluorine In Pharmaceutical And Medicinal Chemistry: From Biophysical Aspects To Clinical Applications
Inbunden, Engelska, 2012
2 874 kr
Skickas inom 3-6 vardagar
Fluorine chemistry is an expanding area of research that is attracting international interest, due to the impact of fluorine in drug discovery and in clinical and molecular imaging (e.g. PET, MRI). Many researchers and academics are entering this area of research, while scientists in industrial and clinical environments are also indirectly exposed to fluorine chemistry through the use of fluorinated compounds for imaging.This book provides an overview of the impact that fluorine has made in the life sciences. In the first section, the emphasis is on how fluorine substitution of amino acids, peptides, nucleobases and carbohydrates can provide invaluable information at a molecular level. The following chapters provide answers to the key questions posed on the importance of fluorine in drug discovery and clinical applications. For examples, the reader will discover how fluorine has found its place as a key element improving drug efficacy, with reference to some of the best-selling drugs on the market. Finally, a thorough review on the design, synthesis and use of 18F-radiotracers for positron emission tomography is provided, and this is complemented with a discussion on how 19F NMR has advanced molecular and clinical imaging.
Del 7 - Molecular Medicine And Medicinal Chemistry
Alzheimer's Disease: Insights Into Low Molecular Weight And Cytotoxic Aggregates From In Vitro And Computer Experiments - Molecular Basis Of Amyloid-beta Protein Aggregation And Fibril Formation
Inbunden, Engelska, 2013
2 261 kr
Skickas inom 5-8 vardagar
Alzheimer's disease is the most common form of senile dementia, affecting more than 24 million people worldwide. It is characterised pathologically by abnormally high levels of neurofibrillary tangles resulting from the accumulation of tau protein in dead and dying neurons, and by elevated numbers of senile plaques in the cortex and hippocampus of the brain. The major component of senile plaques is a small protein of 39-43 amino acids called amyloid-β (Aβ). Thus far, no treatment has been shown to slow the progression of sporadic and familial Alzheimer's disease.A large body of evidence points, however, to the early Aβ-formed oligomers as the primary toxic species in Alzheimer's disease. A powerful strategy for developing pharmaceutical treatments against Alzheimer's is to elucidate the pathways of oligomer formation and determine the structures of the toxic aggregates.This book provides a panoramic view across recent in vitro and in vivo studies along with state-of-the-art computer simulations, designed to increase the readers' understanding of Aβ oligomerisation and fibril formation. At the same time, the book delves into the pathogenesis of familial and sporadic Alzheimer's disease at the atomic level of detail.Written by leading authors in their respective fields, this book will be valuable to all scientists working on Alzheimer's disease.