Pharmaceutical Science Series – serie

Recent advances in cytotoxins and immunotoxins are accelerating our understanding of cancer and leading to more effective therapeutic treatments. Although a large number of articles have been published on these cytotoxins and immunotoxins, this important information has yet to be compiled into one comprehensive resource.For the first time, Cytotoxins and Immunotoxins for Cancer Therapy: Clinical Applications presents state-of-the-art information on various cytotoxins and immunotoxins in a single, highly anticipated publication. The editors bring together leading researchers to summarize their work and discuss clinical trial data concerning some of the most widely studied tumors. The book describes Pseudomonas exotoxin (PE)-based immunotoxins and presents the latest results from clinical trials for the treatment of recurrent glioblastoma and other human cancers. It reviews the role of ricin-based immunotoxins for the treatment of lymphoma, explores several DT-based immunotoxins, and details the preclinical and clinical development of the first FDA-approved cytotoxin.With a focus on clinical developmental approaches to the use of cytotoxins and immunotoxins, this book discusses exciting possibilities for cancer therapy. It is a valuable resource for scientists, researchers, and clinicians involved in the development of new treatments that can help keep cancer under control, and may ultimately lead to a cure.

The Beta-3 Adrenoreceptor plays an important role in regulating human fat storage and variants of this receptor are thought to be relevant to diabetes.In addition to the major interest in obesity and diabetes expressed by the pharmaceutical industry, increasing numbers of academic groups are attracted by this general research area. This renewed interest is of course in part stimulated by available financing from industry. It also reflects the growing realisation that metabolism remains an open frontier: little is known about adipocyte sub-populations, specific markers, or endocrine functions. Research on the ß3 adrenoreceptor and discussion about the hypothetical ß4 adrenoreceptor is currently stimulating considerable interest which will certainly be satisfied by this volume. The Beta-3 Adrenoreceptor will appeal to readers at graduate and post-graduate levels of all major universities and other research and education institutes.