Research and Perspectives in Longevity – serie
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Understanding the relationship between frailty and longevity becomes increasingly important as the world continues to age and life expectancy in most countries continues to increase. The articles contained in this book are the outcome of a colloquium sponsored by Fondation IPSEN in which interdisciplinary perspectives were brought to bear on conceptual, empirical and clinical aspects of this relationship.
2 189 kr
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Understanding the relationship between frailty and longevity becomes increasingly important as the world continues to age and life expectancy in most countries continues to increase. The articles contained in this book are the outcome of a colloquium sponsored by Fondation IPSEN in which interdisciplinary perspectives were brought to bear on conceptual, empirical and clinical aspects of this relationship.
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In this third volume on longevity Fondation Ipsen has again collected the most recent results in research on genes and diet in the evolution of human longevity, educational level and longevity, cognitive impairment and survival at older age and other contributions. The preponderance of relatively short - compared to long-lived organisms suggests that morphogenesis is easier to accomplish than is maintenace of soma, whereas the broad range of longevities of organisms demonstrates that maintaining soma for extended periods of time is possible. The underlying assumption of "disposable soma" theory of aging is that the expense of maintaining somatic cells depends on their contribution to the welfare of the germ cells.
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A central concept in the evolutionary theory of senescence is the idea that ageing results from life-history trade-offs. In particular, the disposable soma theory suggests that longevity is determined through the setting of longevity assurance mechanisms so as to provide an optimal compromise between investments in somatic maintenance (including stress resistance) and in reproduction. Comparative studies among mammalian species confirm that cells from long-lived species appear to have a greater intrinsic capacity to withstand stresses than cells from short-lived species. Childbearing at older ages has become increasingly common in modern societies because of demographic changes, medical progress and personal choice. While the detrimental effects of late reproduction on infant mortality and genetic diseases have been well documented, little is known about the possible postponed detrimental effects of late parenting.
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An ever greater number of our contemporaries will reach a very much greater age than their ancestors. Longevity is one of the most fertile fields for paradoxes: it is clear that the same causes do not produce the same effects at the age of ten and at the age of one hundred! On the subject of longevity, the "recipe book" is far from having been written. Nevertheless, the Fondation IPSEN has chosen a few of these paradoxes to discuss and try and explain them.
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Why longevity? For a number of years, the Fondation IPSEN has been devoting considerable effort to the various aspects of ageing, not only to age-related diseases such as Alzheimer's, but also to the Centenarians, the paragon of positive ageing. The logical continuation of this approach is to address the question of longevity in global terms. Behind the extreme values, what span is accessible to all of us and likely to directly concern most of our contemporaries? The individual and col lective increase in the duration of life is one of the most striking phenomena of our time. It could be one of the most significant events in the "bio-social" history of humanity. The increase in life expectancy at old age, which started a few de cades ago only, is going on. The most well-advised observer had not foreseen or even dared hope for this increase which will drastically affect our everyday life, our habits and our behavior. In the fragment of human history we are living in, it is our responsibility to deal with this major transformation for the species. Such a transformation needs an effort from all to adapt to the new conditions. This transformation has to be managed rather than simply experienced, anticip ated rather than followed, in order to avoid any attempt to pervert this major step forward. All that was present during the first symposium of the new series on longevity of the Colloques Medecine et Recherche convened by the Fondation IPSEN.