Respiratory Disease Series: Diagnostic Tools and Disease Managements – serie

This book considers chronic obstructive pulmonary disease (COPD) not as a simple inflammation of the lung but as a systemic inflammatory disease. Beginning with epidemiological studies, etiology, diagnosis and treatment, it elaborates further, illustrating some comorbidities and associations with other respiratory diseases. As such it provides numerous improved and more comprehensive treatment methods, including drug therapies as well as some non-drug therapies.  There are also chapters describing the pathogenesis, genetic abnormalities and newly discovered pathogenetic mechanisms that are expected to be studied further in the future.Edited and written by pioneering researchers, each chapter summarizes the latest trends, describes future prospects and explores the unresolved and critical questions. Chronic Obstructive Pulmonary Disease - A Systemic Inflammatory Disease is a valuable resource to beginning researchers, physicians engaged in clinical practice, supervisors, and basic researchers whose work includes COPD.

This book covers various aspects of a respiratory system disorder associated with prescribed drugs that do not yet have established treatment guidelines, and for which the only treatment is to discontinue taking the drug. Very little clinical evidence regarding the disorder is available, since randomized trials cannot to be carried out, the onset of the disorder cannot be predicted, and the resulting pathological condition is life-threatening. However, the need for an established treatment continues to grow due to the introduction of many new drugs, such as anti-neoplastic drugs, biological products, and molecular target drugs, the adverse effects of which are difficult to differentiate from those of other lung diseases, such as lung infectious diseases. Drug-Induced Lung Injury offers a highly beneficial resource not only for respiratory physicians but also all medical clinicians who prescribe drugs, nurses, pharmacists and pharmaceutical scientists. Written by pioneering experts in the field, the book examines a wealth of cases and the insights they yield concerning the diagnosis, treatment and specific drugs causing the disease. It not only fosters a deeper understanding of the disorder but also highlights the current challenges and paves the way for future clinical research.

This book describes the underlying genetic basis of common pulmonary diseases and discusses their pathogenesis and pathophysiology. These insights provide the basis for understanding different subtypes and phonotypes, and will promote better treatment strategies and individualized medicine. The book provides new and valuable information for the development of the areas of study, as well as practical guidelines for clinicians engaged in treating pulmonary diseases.This volume of the Respiratory Disease Series – Diagnostic Tools and Disease Managements will broaden the understanding of beginning and experienced researchers and clinicians who treat pulmonary diseases. Moreover, residents and clinicians engaged in medical oncology will find it a valuable guide to support them in their day-to-day work.

This book considers chronic obstructive pulmonary disease (COPD) not as a simple inflammation of the lung but as a systemic inflammatory disease. Beginning with epidemiological studies, etiology, diagnosis and treatment, it elaborates further, illustrating some comorbidities and associations with other respiratory diseases. As such it provides numerous improved and more comprehensive treatment methods, including drug therapies as well as some non-drug therapies.  There are also chapters describing the pathogenesis, genetic abnormalities and newly discovered pathogenetic mechanisms that are expected to be studied further in the future.Edited and written by pioneering researchers, each chapter summarizes the latest trends, describes future prospects and explores the unresolved and critical questions. Chronic Obstructive Pulmonary Disease - A Systemic Inflammatory Disease is a valuable resource to beginning researchers, physicians engaged in clinical practice, supervisors, and basic researchers whose work includes COPD.

This book provides valuable data on the outbreak, aggravation, treatment and prevention of respiratory diseases based on prior experiences of natural disasters such as earthquakes and tsunamis. Poor hygiene and air pollution can lead to the onset of pneumonia and other respiratory disease, while a lack of medical supplies aggravates existing pulmonary diseases such as chronic obstructive pulmonary disease and asthma. Furthermore, there are cases where those forced to live in cramped conditions, such as cars, following a disaster have developed pulmonary thromboembolism as a result of deep vein thrombosis. The large numbers of patients diagnosed with respiratory diseases make understanding the links between natural disasters and pulmonary disease vital.Disaster and Respiratory Diseases is a valuable resource for all medical staff, including physicians involved in primary care, respiratory medicine and infection control and emergency medicine, as well as respiratory surgeons. Itis also useful to national and regional governments concerned about anti-disaster measures.​

This book provides discussions on bronchial asthma from a clinical perspective, focusing on the recent studies on its pathophysiology, diagnosis and treatment. It also explores the lastest findings regarding the phenotypes and endotypes of asthmatic patients, making it of particular interest to those involved with non-eosinophilic asthma and eosinophilic asthma. Further, it discusses the importance of ILC 2 in eosinophilic asthma, and the accumulated results from the forced oscilliation technique and periostin that are actively practiced in Japan. As some aspects of diagnosis and treatment are different in Western and Asian countries, it is important that the data is disseminated around the globe. The clinical questions addressed by the authors are critical and thought provoking, while the questions raised by the editors are instructive, informative and provide new perspectives on unresolved issues. This book appeals to wide readership from beginning learners to physicians in clinical practice and scholars engaging in basic research.

This book describes the underlying genetic basis of common pulmonary diseases and discusses their pathogenesis and pathophysiology. These insights provide the basis for understanding different subtypes and phonotypes, and will promote better treatment strategies and individualized medicine. The book provides new and valuable information for the development of the areas of study, as well as practical guidelines for clinicians engaged in treating pulmonary diseases.This volume of the Respiratory Disease Series – Diagnostic Tools and Disease Managements will broaden the understanding of beginning and experienced researchers and clinicians who treat pulmonary diseases. Moreover, residents and clinicians engaged in medical oncology will find it a valuable guide to support them in their day-to-day work.

This book covers various aspects of a respiratory system disorder associated with prescribed drugs that do not yet have established treatment guidelines, and for which the only treatment is to discontinue taking the drug. Very little clinical evidence regarding the disorder is available, since randomized trials cannot to be carried out, the onset of the disorder cannot be predicted, and the resulting pathological condition is life-threatening. However, the need for an established treatment continues to grow due to the introduction of many new drugs, such as anti-neoplastic drugs, biological products, and molecular target drugs, the adverse effects of which are difficult to differentiate from those of other lung diseases, such as lung infectious diseases. Drug-Induced Lung Injury offers a highly beneficial resource not only for respiratory physicians but also all medical clinicians who prescribe drugs, nurses, pharmacists and pharmaceutical scientists. Written by pioneering experts in the field, the book examines a wealth of cases and the insights they yield concerning the diagnosis, treatment and specific drugs causing the disease. It not only fosters a deeper understanding of the disorder but also highlights the current challenges and paves the way for future clinical research.

This book offers an essential overview of aspiration pneumonia, and focuses on four major aspects: epidemiology, pathophysiology, new preventive strategies, and trending topics. Each part presents detailed findings and insights into critical issues for the treatment of the disease including its diagnosis, assessment, selecting antibiotics, similarities and differences between aspiration risk and aspiration pneumonia risk, different therapeutic approaches and so on. The book also discusses emerging topics concerning the definition of NHCAP and sleep apnea. Special attention is given to therapeutic and preventive approaches for the elderly, highlighting recent advances and the evidence on their positive outcomes. Since the patients with this disorder are often in a post-stroke state and elderly, the book is highly relevant for neurologists and geriatric physicians. Further, many surgeons also face this type of pneumonia in association with postoperative complications and cancertherapy related complications. Lastly, the definition of aspiration pneumonia and its therapeutic strategy have yet to be established in many countries, and the data presented here should serve as a guideline for its future diagnosis and treatment. As such, the book offers a valuable resource for primary physicians, pulmonologists, gerontologists, respiratory nurses, physical therapists, dentists and otolaryngologists alike.

This book offers an essential overview of aspiration pneumonia, and focuses on four major aspects: epidemiology, pathophysiology, new preventive strategies, and trending topics. Each part presents detailed findings and insights into critical issues for the treatment of the disease including its diagnosis, assessment, selecting antibiotics, similarities and differences between aspiration risk and aspiration pneumonia risk, different therapeutic approaches and so on. The book also discusses emerging topics concerning the definition of NHCAP and sleep apnea. Special attention is given to therapeutic and preventive approaches for the elderly, highlighting recent advances and the evidence on their positive outcomes. Since the patients with this disorder are often in a post-stroke state and elderly, the book is highly relevant for neurologists and geriatric physicians. Further, many surgeons also face this type of pneumonia in association with postoperative complications and cancertherapy related complications. Lastly, the definition of aspiration pneumonia and its therapeutic strategy have yet to be established in many countries, and the data presented here should serve as a guideline for its future diagnosis and treatment. As such, the book offers a valuable resource for primary physicians, pulmonologists, gerontologists, respiratory nurses, physical therapists, dentists and otolaryngologists alike.

This book elucidates the morphological backgrounds of various functional parameters of the human respiratory system, including the respiratory control system, dynamics of the upper and lower airways, gas transport and mixing in the lower airways, gas exchange in the acinus, and gas transfer through the alveolar wall. Presenting the latest findings on the interrelationships between morphology and physiology in the respiratory system, the book’s goal is to provide a foundation for further exploring structure-function relationships in various respiratory systems, and to improve both the quality of basic science, and that of clinical medicine targeting the human respiratory system.Edited and written by internationally recognized experts, Structure-Function Relationships in Various Respiratory Systems offers a valuable asset for all physicians and researchers engaging in clinical, physiological, or morphological work in the field of respiration. Moreover, it provides a practical guide for physicians, helping them make more precise pathophysiological decisions concerning patients with various types of lung disease, and will be of interest to respiratory physiologists and respiratory morphologists.

This book elucidates the morphological backgrounds of various functional parameters of the human respiratory system, including the respiratory control system, dynamics of the upper and lower airways, gas transport and mixing in the lower airways, gas exchange in the acinus, and gas transfer through the alveolar wall. Presenting the latest findings on the interrelationships between morphology and physiology in the respiratory system, the book’s goal is to provide a foundation for further exploring structure-function relationships in various respiratory systems, and to improve both the quality of basic science, and that of clinical medicine targeting the human respiratory system.Edited and written by internationally recognized experts, Structure-Function Relationships in Various Respiratory Systems offers a valuable asset for all physicians and researchers engaging in clinical, physiological, or morphological work in the field of respiration. Moreover, it provides a practical guide for physicians, helping them make more precise pathophysiological decisions concerning patients with various types of lung disease, and will be of interest to respiratory physiologists and respiratory morphologists.

This book explores the latest research and practical data on the clinical management of influenza. Starting with the definition, epidemiology and pathogenesis, the first part reviews the basic science of the influenza virus and infection. The next three parts then discusses the diagnosis, complications and management, providing practical data and insights that are useful in day-to-day patient care. The last part focuses on the trending topics, including a new drug, oral baloxavir marboxil, which was introduced in Japan in 2018 and is the first polymerase inhibitor to be licensed for the treatment of uncomplicated influenza. In Japan, since the medical insurance system is well-established, patients receive medical examinations quickly after the onset of influenza viral infection, making it easy to implement early diagnostic tools and early treatment. Providing practical data and insights, Influenza - Advances in Diagnosis and Management is a useful resource for clinicians, residents and trainees around the globe.

This book explores the latest research and practical data on the clinical management of influenza. Starting with the definition, epidemiology and pathogenesis, the first part reviews the basic science of the influenza virus and infection. The next three parts then discusses the diagnosis, complications and management, providing practical data and insights that are useful in day-to-day patient care. The last part focuses on the trending topics, including a new drug, oral baloxavir marboxil, which was introduced in Japan in 2018 and is the first polymerase inhibitor to be licensed for the treatment of uncomplicated influenza. In Japan, since the medical insurance system is well-established, patients receive medical examinations quickly after the onset of influenza viral infection, making it easy to implement early diagnostic tools and early treatment. Providing practical data and insights, Influenza - Advances in Diagnosis and Management is a useful resource for clinicians, residents and trainees around the globe.

This book provides essential information on recent advances in molecular genetics, epidemiology, translational research, and the latest results of clinical trials on mesothelioma. Significant progress has been made in understanding mesothelioma biology, and in developing new therapies for this refractory tumor, malignant pleural mesothelioma (MPM). Not only does this volume summarize the latest research-based data on the disease; it also shares insights into future research directions.The book consists of 5 themed sections on: epidemiology, pathogenesis, screening and early detection, molecular genetics, and clinical aspects and management. Several chapters focus on new trends in the field, e.g. immune therapy and identification of biomarkers, molecular oncogenesis including genetic susceptibility, and molecular diagnostic pathology. The book also highlights new cancer treatment approaches, such as immunotherapy based on immune checkpoint inhibitors, which has meanta paradigm shift in other types of cancer, and given some hope to MPM patients. In turn, it discusses recent molecular pathological studies on mesothelioma, which claim to offer more accurate classifications than traditional morphology and immunohistochemistry-based approaches. All of these cutting-edge analyses provide the basis for a closing discussion on future developments and research directions.Malignant Pleural Mesothelioma - Advances in Pathogenesis, Diagnosis, and Treatments has been edited and authored by respected researchers and will be of interest to medical, surgical and radiation oncologists; pulmonologists; pathologists and basic researchers alike. Since the disease represents a significant diagnostic and therapeutic challenge, scientists and clinicians from learners to experts, as well as fellows in training in these subspecialties, will value this book.

This book provides essential information on recent advances in molecular genetics, epidemiology, translational research, and the latest results of clinical trials on mesothelioma. Significant progress has been made in understanding mesothelioma biology, and in developing new therapies for this refractory tumor, malignant pleural mesothelioma (MPM). Not only does this volume summarize the latest research-based data on the disease; it also shares insights into future research directions.The book consists of 5 themed sections on: epidemiology, pathogenesis, screening and early detection, molecular genetics, and clinical aspects and management. Several chapters focus on new trends in the field, e.g. immune therapy and identification of biomarkers, molecular oncogenesis including genetic susceptibility, and molecular diagnostic pathology. The book also highlights new cancer treatment approaches, such as immunotherapy based on immune checkpoint inhibitors, which has meanta paradigm shift in other types of cancer, and given some hope to MPM patients. In turn, it discusses recent molecular pathological studies on mesothelioma, which claim to offer more accurate classifications than traditional morphology and immunohistochemistry-based approaches. All of these cutting-edge analyses provide the basis for a closing discussion on future developments and research directions.Malignant Pleural Mesothelioma - Advances in Pathogenesis, Diagnosis, and Treatments has been edited and authored by respected researchers and will be of interest to medical, surgical and radiation oncologists; pulmonologists; pathologists and basic researchers alike. Since the disease represents a significant diagnostic and therapeutic challenge, scientists and clinicians from learners to experts, as well as fellows in training in these subspecialties, will value this book.

Divided into thirteen chapters, this book provides a wealth of research-oriented findings and practical guidance, ranging from the definition, epidemiology and pathophysiology, to the diagnosis and management of the disease. Although acute respiratory distress syndrome (ARDS) is defined by the acute onset of noncardiogenic pulmonary edema, hypoxemia and the need for mechanical ventilation, it is a heterogeneous disease entity, which makes it difficult to develop specific therapies. Treatment tends to focus on lung-protective ventilation, and no specific pharmacotherapies have been identified. All chapters were written by respected experts in the field, and summarize the latest trends, share recent research findings, and outline future prospects. Specific chapters are devoted to novel, promising diagnostic approaches, such as microRNA, which may improve our ability to identify early ARDS or at-risk patients. In addition, a dedicated chapter explores cell-based therapies and regenerative medicine, which offer potential therapeutic options.Acute Respiratory Distress Syndrome - Advances in Diagnostic Tools and Disease Management offers a valuable reference guide not only for young physicians and trainees, but also for experienced or teaching physicians, medical educators, and basic researchers. Readers will find the latest information on ARDS and come to understand the current challenges, encouraging them to further advance the diagnosis, treatment and clinical research on this disease.

Divided into thirteen chapters, this book provides a wealth of research-oriented findings and practical guidance, ranging from the definition, epidemiology and pathophysiology, to the diagnosis and management of the disease. Although acute respiratory distress syndrome (ARDS) is defined by the acute onset of noncardiogenic pulmonary edema, hypoxemia and the need for mechanical ventilation, it is a heterogeneous disease entity, which makes it difficult to develop specific therapies. Treatment tends to focus on lung-protective ventilation, and no specific pharmacotherapies have been identified. All chapters were written by respected experts in the field, and summarize the latest trends, share recent research findings, and outline future prospects. Specific chapters are devoted to novel, promising diagnostic approaches, such as microRNA, which may improve our ability to identify early ARDS or at-risk patients. In addition, a dedicated chapter explores cell-based therapies and regenerative medicine, which offer potential therapeutic options.Acute Respiratory Distress Syndrome - Advances in Diagnostic Tools and Disease Management offers a valuable reference guide not only for young physicians and trainees, but also for experienced or teaching physicians, medical educators, and basic researchers. Readers will find the latest information on ARDS and come to understand the current challenges, encouraging them to further advance the diagnosis, treatment and clinical research on this disease.

Every year, 10 million people fall ill with tuberculosis (TB) in the world, and of those, 1.5 million people die even though it is a preventable and curable disease. As a result, TB remains the world’s leading infectious cause of death. On the other hand, in industrialized countries, the TB incidence has fallen to a historic low, and clinicians’ experience with TB diminished significantly in recent years. Additional challenges for clinicians include atypical presentation of TB in the immunocompromised, especially among the elderly, and an increasing number of patients with drug-resistant TB. Delayed diagnosis of TB leads to the spread of TB including nosocomial transmission because TB is an air-borne infectious disease, and suboptimal treatment can result in development of drug resistance.  Furthermore, treatment of latent TB infection (LTBI) can prevent future TB cases but it has been under-utilized despite recent innovations in diagnosis and treatment regimens of LTBI. This bookfocuses on advances in diagnostic tools and treatment for both TB disease and latent TB infection. Each chapter/topic is written by one of the top TB experts in the field and the authors are from Japan and the US.  Pulmonary Tuberculosis and its Prevention offers up-to-date information that can be incorporated into a busy practice of clinicians while they can appreciate broad international perspectives and gain in-depth knowledge on TB.

This book elucidates the diagnostic criteria and concept of asthma-COPD overlap (ACO) and provides the latest information on its epidemiology, pathophysiology, diagnostic criteria, and treatment options. It discusses the controversy-causing findings of prognosis of ACO, the novel molecular mechanism including nitrosative stress, radiological or physiological features, findings by research that used HRCT or forced oscillation technique. In addition to a recent animal model of ACO, the role of each biomarker, the latest results of ICS/LAMA/LABA combination inhalers or biologics is also debated.Asthma COPD Overlap -Updated Concept, Pathophysiology, Diagnosis, and Treatment is addressed not only to beginners, but also to physicians engaged in clinical practice, supervisors, and many basic researchers. Covering every aspect of ACO, it serves readers to improve diagnosis or treatment for patients with ACO.

This book elucidates the diagnostic criteria and concept of asthma-COPD overlap (ACO) and provides the latest information on its epidemiology, pathophysiology, diagnostic criteria, and treatment options. It discusses the controversy-causing findings of prognosis of ACO, the novel molecular mechanism including nitrosative stress, radiological or physiological features, findings by research that used HRCT or forced oscillation technique. In addition to a recent animal model of ACO, the role of each biomarker, the latest results of ICS/LAMA/LABA combination inhalers or biologics is also debated.Asthma COPD Overlap -Updated Concept, Pathophysiology, Diagnosis, and Treatment is addressed not only to beginners, but also to physicians engaged in clinical practice, supervisors, and many basic researchers. Covering every aspect of ACO, it serves readers to improve diagnosis or treatment for patients with ACO.

This book is a comprehensive guide to the epidemiology and social issues of sleep apnea and sleep related disturbances, as well as a wide range of treatment options, including weight loss and positional therapy, CPAP therapy, oral devices, implantable therapy, and telemedicine. The book also explores the relationship between sleep apnea and other health conditions, such as cardiovascular disease and metabolic disorders. While focusing on global perspectives, the book includes a chapter devoted explicitly to treatment options in Japan and insights into the latest research from around the world.The Current State of Sleep Disordered Breathing in Japan and Around the World is published under the Book Series Respiratory Disease Series: Diagnostic Tools and Disease Management, focusing on practical solutions and cutting-edge research. This book is an essential resource for healthcare providers, researchers, and anyone interested in the study of sleep disorders. The breadth of coverage makes the book a valuable source for healthcare providers, researchers, and anyone interested in studying sleep disorders.