Sheffield Analytical Chemistry Series – serie

As an integral component of environmental policy, it has become essential to regulate and monitor toxic substances. Past emphasis has been primarily on analytical approaches to the detection of specific, targeted contaminants, thus allowing chemical characterisation. However, toxicity testing or biological assessment is necessary for ecotoxicological evaluation, and this offers marked benefits and advantages that complement chemical analysis.Key issues to be addressed include identification of pertinent tests, reproducibility and robustness of these tests, and cost considerations.This book examines these issues and describes and explains the approaches that have been developed for environmental toxicity evaluations. Advantages, benefits and drawbacks of the strategies and methods are highlighted. Directed equally at ecotoxicologists, industrial chemists, analytical chemists and environmental consultants, this book is written in a way that will prove helpful to both new and experienced practitioners.

The first edition of Inductively Coupled Plasma Spectrometry and its Applications was written as a handbook for users who wanted a better understanding of the theory augmented by a practical insight of how best to approach a range of applications, and to provide a useful starting point for users trying an approach or technique new to them. These objectives have been retained in the second edition but a slight shift in emphasis gives the volume an overall perspective that is more forward looking. Structured into 11 chapters, the current edition is a thorough revision of the original, covering the principles of inductively coupled plasmas, instrumentation, methodology and applications within environmental analysis, earth science, food science and clinical medicine. Each chapter, written by internationally recognised leaders in their specific subject areas, provides enough detail to be useful to both the new and experienced users. Full account is taken of recent developments, such as high resolution instruments, novel detection systems and electrospray techniques. Written for all analytical scientists but particularly those involved in atomic spectroscopy and in environmental, geochemical, clinical or food analysis, this timely and informative book will be an essential reference in their use of inductively coupled plasmas to achieve their own scientific goals.

This volume concentrates on the attributes, requirements and applications of spectroscopic techniques in process analysis, considering off-line and at-/near-line methodology, in addition to on-line, in-line and non-invasive approaches. At a time when cost- and time-effective process spectroscopy is becoming an issue of increasing importance within the chemical industry, this volume provides a valuable source of up-to-date information on technological advances in the area. It complements more general works on process analytical chemistry.

The last few years have seen significant developments in many aspects of gas chromatography. In this volume, authors drawn from industrial and academic laboratories around the world consider developments over the last decade, with an emphasis on the new technologies. Application areas are addressed within chapters. This is a book for analytical chemists, organic chemists, environmental scientists, food scientists and pharmaceutical chemists in the academic and industrial sectors.

The use of analytical sciences in the discovery, development and manufacture of pharmaceuticals is wide-ranging. From the analysis of minute amounts of complex biological materials to the quality control of the final dosage form, the use of analytical technology covers an immense range of techniques and disciplines. This book concentrates on the analytical aspects of drug development and manufacture, focusing on the analysis of the active ingredient or drug substance. It provides those joining the industry or other areas of pharmaceutical research with a source of reference to a broad range of techniques and their applications, allowing them to choose the most appropriate analytical technique for a particular purpose. The volume is directed at analytical chemists, industrial pharmacists, organic chemists, pharmaceutical chemists and biochemists.

This volume covers techniques of extraction and sample preparation, addressing background theory, the available instrumentation and the strengths and weaknesses of each method. Key applications areas are highlighted. The book is thoroughly referenced and indexed.

Recent years have seen massive changes in the tools and instrumentation available to chemists, in the scale of databases linking the properties of pure materials, solutions or other mixtures to molecular structure, and in the sheer ability of chemists to collect data through automated data acquisition systems. Despite these advances, many chemists still apply only rudimentary data analysis techniques and remain unaware of the advances made in information extraction over the last decade or so. This volume covers the principles of design and analysis in chemical research and development. It is organised in chapters dealing with major activities, and understanding is generated through large numbers of examples and practical applications relating to research and development chemistry. Authors adopt a user-friendly approach, concentrating on principles and interpretation rather than formal derivation and proof. A principal theme is that statistics and chemometrics (which relies on statistics) are essentially extensions of the logical processes used every day by chemists, and that they bring greater understanding of problems more quickly and easily than purely intuitive methods.

A key component of the overall quality of a pharmaceutical is control of impurities, as their presence, even in small amounts, may affect drug safety and efficacy. The identification and quantification of impurities to acceptable standards presents a significant challenge to the analytical chemist. Analytical science is developing rapidly and provides increasing opportunity to identify the structure, and therefore the origin and safety implications of these impurities, and the challenges of their measurement drives the development of modern quantitative methods. Written for both practicing and student analytical chemists, Analysis of Drug Impurities provides a detailed overview of the challenges and the techniques available to permit accurate identification and quantification of drug impurities.