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14 produkter
14 produkter
Ecstasy: The Clinical, Pharmacological and Neurotoxicological Effects of the Drug MDMA
Inbunden, Engelska, 1989
2 178 kr
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The variety of viewpoints expressed in this book illustrate the many contro versies surrounding MDMA [1]. On the one hand, the proponents ofMDMA use believe this agent offers a unique psychoactive effect that may have important clinical applications, especially in the field of psychotherapy. On the other hand, the scientific data concerning the neurotoxic effects of the drug are unequivocal. The most striking feature of the human information of MDMA is the paucity of data that has been generated on the drug since it was patented in 1914. As pointed out by Beck (Chapter 6) and others, a clear need exists for better epidemiological and clinical data on MDMA. In the absence of such data, arguments both for and against the cotinued use ofMDMA with humans will be difficult to support. Unfortunately, the currently available data must be used to develop rational policies for potential human users of MDMA. At the present time, there are no data indicating that recreational doses of MDMA permanently damage the human brain. Nonetheless, based on a review of the contents of this book as well as on informal discussions with approximately 200 recreational users of MDMA, the following personal observations suggest that MDMA is radically different from other recreational drugs.
2 111 kr
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This symposium entitled Calcium, Neuronal Function and Transmitter Re lease, was in the framework of the regional meeting of the International Union of Physiological Sciences, that took place in Jerusalem between August 26-31, 1984. The symposium dealt with the role of calcium ions in regulation of a large number of important processes in modern neurobiology, from molecular and cellular points of view. In this context, we consider heart and most cells as 'honorary neurons'. The meeting was comprised of lectures and quite intense discussions. We hope that the transcription of the discussions which follow the articles will give the reader a feeling of the intense, but pleasant atmosphere that per vaded during this symposium. It is our pleasure to thank Mrs. Miriam Silber, the assistant editor of this book, for her hard work in transcribing the discussions, retyping large portions of the book, and getting the approval of the authors. We express our thanks to Dr. Halina Meiri and Dr. Simona Ginsburg for their editorial assis tance. The unfailing help of Ms. Rachel Klein and Ms. Shoshana Wineberg is greatly appreciated. xxvii SECTION 1 CALCIUM CHANNELS, TRANSPORTERS & CALCIUM REGULATED CHANNELS EFFECTS OF TEMPERATURE ON SINGLE CHANNEL AND WHOLE CELL Ca CURRENTS A. M. BROWN, D. L. KUNZE, H.D. LUX AND D. L. WILSON INTRODUCTION Calcium tall currents have a large,fast component which Is not detectable when the currents are turned on or acti vated from the completely rested state (Brown et aI, 1983).
Neuroregulation of Autonomic, Endocrine and Immune Systems
New Concepts of Regulation of Autonomic, Neuroendocrine and Immune Systems
Inbunden, Engelska, 1986
3 163 kr
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Our understanding of the functioning of the brain has grown rapidly over the last decade or two. So has our recognition of the possible role of brain dysfunction in diseases considered earlier to be of peripheral or somatic origin. This culminates naturally in a focus on the nature of the influence of the brain on other systems such as the autonomic, neuroendocrine and immune systems. And we must come full circle and question the nature of the influence of these systems on the function of the brain. Thus, we gain a picture of a complex regulatory interaction, fine tuned in normal circumstances to provide each system with necessary information about the status of the other systems and the basis to respond appropriately to changes in each other. This volume provides the proceedings of the first of a series of international symposia intended to review the state-of-the-art understanding and frontier exploration of the above described interregulatory phenomena, with some emphasis on the relevance of this information to the etiology and treatment of disease. The purpose of this first symposium was to lay the groundwork for this continuing endeavor. To accomplish such a goal required bringing together diverse multidisciplinary professionals - eg neurobiologists, immunol ogists, psychiatrists, cardiologists and students amongst others.
Del 3 - Topics in the Neurosciences
Role of RNA and DNA in Brain Function
A Molecular Biological Approach
Inbunden, Engelska, 1986
2 111 kr
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There was once an old Chinese man working on a hill with a boy. On the plain, near the sea, rested the village, the inhabitants eagerly engaged in their daily activities. Suddenly, the old man noticed that a huge wave, far distant in the sea, was approaching the shore endangering all. The only safe place was the hill. So, he began waving his hands and screaming aloud, to no avail. The villagers were too busy with their own work and paid little heed to the old man, who was considered a bit eccentric. But soon flames were on the hill, the wheat fields ablaze. The old man had resorted to this ultimate step to alert his fellow citizens. Now, they all went running towards him, angry about their burning crop, and in the process, avoided the imminent danger. For some mysterious reason, my mind focused on this story prior to the Symposium on the Role of DNA, which took place in Ravello, Italy at the end of May 1985. Having made a call for people to meet and reflect for a few days, the analogy began to take shape. Ravello was indeed a hill, magically overlooking the sea from medieval quarters. True, its countryside is filled with vineyards, not wheat fields, but that is an improvement on the story. However, what was the wave? Perhaps, the growing amount of data on cloned brain genes that threatens to engulf neurobiologists.
Central Nervous System Control of the Heart
Proceedings of the IIIrd International Brain Heart Conference Trier, Federal Republic of Germany
Inbunden, Engelska, 1986
1 632 kr
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The first two "Brain Heart Conferences" in Jerusalem in 1978 and 1983 were based upon the common interests of clinically orientated neurologists and cardiologists in the problems of centr'al autonomic control and autonomic disturbances of the cardiovascular system. The relatively slow scientific progress, at least clinically, in this area may be due to the fact that neither cardiologists nor neurologists felt competent in both topics. Furthermore, it has become increasingly difficult to have an overall view of the basic research and its clinical applications in this field. New research methods, based on a comtination of morphological, biochemical, and physiological techniques, have enabled the functional differentiation of various areas of the brain and subsequently also of the autonomic nervous system. The simple dualistic concept of an antagonistic sympathetic-parasympathetic regulation of the circulatory system is no longer valid. It is clear that numerous neurotransmitters, in particular the neuropeptides, are involved in a highly differentiated subdivision of the autonomic system. One of the aims of the IIIrd International Brain Heart Conference was therefore to supply a synopsis of the latest developments in basic research undertaken in this field by exceptionally competent scientists, to clinically orientated neurologists and cardiologists, and thus to provide new impulses for clinical research.
1 091 kr
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Plasma cell dyscrasias are common causes of peripheral neuropathy. Peri- pheral neuropathy may be the first manifestation of multiple myeloma, amyloidosis, or monoclonal gammopathy of undetermined significance (MGUS). Peripheral neuropathy occurs in more than one-half of patients with osteosclerotic myeloma. The hematologic disorders are such an important association with peripheral polyneuropathy that, for the last decade, we have obtained a metastatic bone survey and immunoelectrophoresis of serum and a 24-hour urine specimen on all patients older than 40 years with undiagnosed peripheral neuropathy. This textbook on polyneuropathies and plasma cell dyscrasia is welcome, because the subject is of considerable medical importance and because the authors are expert in these disorders. Kelly's studies have shown that a systematic search for monoclonal proteins in plasma and urine among patients with neuropathy of unknown cause increases diagnostic yield. Latov's studies have focused on the role of myelin associated glycoproteins (MAG) in the induction of neuropathy.Kyle, director of the Special Protein Laboratory at Mayo Clinic, brings a broad clinical and laboratory perspective and experi- ence. The timing of the textbook is just right, because there is much new information which needs to be summarized.
1 632 kr
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At the end of September 1984 Dr. M. Velickovi~ and Prof. H. Prechtl with the help of the International Cerebral Palsy Society organized an international conference on "New develop ments in the assessment of early brain damage" in Bled, Yugo slavia. I was invited as a speaker at this conference and I went there, curious, but without too much knowledge about the central theme: cerebral palsy. During the conference and a satellite meeting I became impressed by the quality of various contributions and also by the great variety of problems related to the etiology, early diagnosis, management and psychosocial aspects of cerebral palsy. Today, in many areas of biology and medicine, progress seems to require concentration on a very narrow field. As a consequence many conferences are highly specialized and most (young) scientists rightly consider this as most useful for their own work. On the other hand the care of patients and counselling of parents and other close relatives require a multidisciplinary approach. Also, advances in the study of complicated un resolved medical biological pr'oblems are often made unex pectedly by using ideas, theories, approaches or methods from other disciplines.
1 092 kr
Skickas inom 10-15 vardagar
Plasma cell dyscrasias are common causes of peripheral neuropathy. Peri- pheral neuropathy may be the first manifestation of multiple myeloma, amyloidosis, or monoclonal gammopathy of undetermined significance (MGUS). Peripheral neuropathy occurs in more than one-half of patients with osteosclerotic myeloma. The hematologic disorders are such an important association with peripheral polyneuropathy that, for the last decade, we have obtained a metastatic bone survey and immunoelectrophoresis of serum and a 24-hour urine specimen on all patients older than 40 years with undiagnosed peripheral neuropathy. This textbook on polyneuropathies and plasma cell dyscrasia is welcome, because the subject is of considerable medical importance and because the authors are expert in these disorders. Kelly's studies have shown that a systematic search for monoclonal proteins in plasma and urine among patients with neuropathy of unknown cause increases diagnostic yield. Latov's studies have focused on the role of myelin associated glycoproteins (MAG) in the induction of neuropathy.Kyle, director of the Special Protein Laboratory at Mayo Clinic, brings a broad clinical and laboratory perspective and experi- ence. The timing of the textbook is just right, because there is much new information which needs to be summarized.
2 115 kr
Skickas inom 10-15 vardagar
This symposium entitled Calcium, Neuronal Function and Transmitter Re lease, was in the framework of the regional meeting of the International Union of Physiological Sciences, that took place in Jerusalem between August 26-31, 1984. The symposium dealt with the role of calcium ions in regulation of a large number of important processes in modern neurobiology, from molecular and cellular points of view. In this context, we consider heart and most cells as 'honorary neurons'. The meeting was comprised of lectures and quite intense discussions. We hope that the transcription of the discussions which follow the articles will give the reader a feeling of the intense, but pleasant atmosphere that per vaded during this symposium. It is our pleasure to thank Mrs. Miriam Silber, the assistant editor of this book, for her hard work in transcribing the discussions, retyping large portions of the book, and getting the approval of the authors. We express our thanks to Dr. Halina Meiri and Dr. Simona Ginsburg for their editorial assis tance. The unfailing help of Ms. Rachel Klein and Ms. Shoshana Wineberg is greatly appreciated. xxvii SECTION 1 CALCIUM CHANNELS, TRANSPORTERS & CALCIUM REGULATED CHANNELS EFFECTS OF TEMPERATURE ON SINGLE CHANNEL AND WHOLE CELL Ca CURRENTS A. M. BROWN, D. L. KUNZE, H.D. LUX AND D. L. WILSON INTRODUCTION Calcium tall currents have a large,fast component which Is not detectable when the currents are turned on or acti vated from the completely rested state (Brown et aI, 1983).
Neuroregulation of Autonomic, Endocrine and Immune Systems
New Concepts of Regulation of Autonomic, Neuroendocrine and Immune Systems
Häftad, Engelska, 2011
3 263 kr
Skickas inom 10-15 vardagar
Our understanding of the functioning of the brain has grown rapidly over the last decade or two. So has our recognition of the possible role of brain dysfunction in diseases considered earlier to be of peripheral or somatic origin. This culminates naturally in a focus on the nature of the influence of the brain on other systems such as the autonomic, neuroendocrine and immune systems. And we must come full circle and question the nature of the influence of these systems on the function of the brain. Thus, we gain a picture of a complex regulatory interaction, fine tuned in normal circumstances to provide each system with necessary information about the status of the other systems and the basis to respond appropriately to changes in each other. This volume provides the proceedings of the first of a series of international symposia intended to review the state-of-the-art understanding and frontier exploration of the above described interregulatory phenomena, with some emphasis on the relevance of this information to the etiology and treatment of disease. The purpose of this first symposium was to lay the groundwork for this continuing endeavor. To accomplish such a goal required bringing together diverse multidisciplinary professionals - eg neurobiologists, immunol ogists, psychiatrists, cardiologists and students amongst others.
2 115 kr
Skickas inom 10-15 vardagar
There was once an old Chinese man working on a hill with a boy. On the plain, near the sea, rested the village, the inhabitants eagerly engaged in their daily activities. Suddenly, the old man noticed that a huge wave, far distant in the sea, was approaching the shore endangering all. The only safe place was the hill. So, he began waving his hands and screaming aloud, to no avail. The villagers were too busy with their own work and paid little heed to the old man, who was considered a bit eccentric. But soon flames were on the hill, the wheat fields ablaze. The old man had resorted to this ultimate step to alert his fellow citizens. Now, they all went running towards him, angry about their burning crop, and in the process, avoided the imminent danger. For some mysterious reason, my mind focused on this story prior to the Symposium on the Role of DNA, which took place in Ravello, Italy at the end of May 1985. Having made a call for people to meet and reflect for a few days, the analogy began to take shape. Ravello was indeed a hill, magically overlooking the sea from medieval quarters. True, its countryside is filled with vineyards, not wheat fields, but that is an improvement on the story. However, what was the wave? Perhaps, the growing amount of data on cloned brain genes that threatens to engulf neurobiologists.
Central Nervous System Control of the Heart
Proceedings of the IIIrd International Brain Heart Conference Trier, Federal Republic of Germany
Häftad, Engelska, 2011
1 635 kr
Skickas inom 10-15 vardagar
The first two "Brain Heart Conferences" in Jerusalem in 1978 and 1983 were based upon the common interests of clinically orientated neurologists and cardiologists in the problems of centr'al autonomic control and autonomic disturbances of the cardiovascular system. The relatively slow scientific progress, at least clinically, in this area may be due to the fact that neither cardiologists nor neurologists felt competent in both topics. Furthermore, it has become increasingly difficult to have an overall view of the basic research and its clinical applications in this field. New research methods, based on a comtination of morphological, biochemical, and physiological techniques, have enabled the functional differentiation of various areas of the brain and subsequently also of the autonomic nervous system. The simple dualistic concept of an antagonistic sympathetic-parasympathetic regulation of the circulatory system is no longer valid. It is clear that numerous neurotransmitters, in particular the neuropeptides, are involved in a highly differentiated subdivision of the autonomic system. One of the aims of the IIIrd International Brain Heart Conference was therefore to supply a synopsis of the latest developments in basic research undertaken in this field by exceptionally competent scientists, to clinically orientated neurologists and cardiologists, and thus to provide new impulses for clinical research.
1 635 kr
Skickas inom 10-15 vardagar
At the end of September 1984 Dr. M. Velickovi~ and Prof. H. Prechtl with the help of the International Cerebral Palsy Society organized an international conference on "New develop ments in the assessment of early brain damage" in Bled, Yugo slavia. I was invited as a speaker at this conference and I went there, curious, but without too much knowledge about the central theme: cerebral palsy. During the conference and a satellite meeting I became impressed by the quality of various contributions and also by the great variety of problems related to the etiology, early diagnosis, management and psychosocial aspects of cerebral palsy. Today, in many areas of biology and medicine, progress seems to require concentration on a very narrow field. As a consequence many conferences are highly specialized and most (young) scientists rightly consider this as most useful for their own work. On the other hand the care of patients and counselling of parents and other close relatives require a multidisciplinary approach. Also, advances in the study of complicated un resolved medical biological pr'oblems are often made unex pectedly by using ideas, theories, approaches or methods from other disciplines.
Del 7 - Topics in the Neurosciences
Ethopharmacology of Agonistic Behaviour in Animals and Humans
Häftad, Engelska, 2011
550 kr
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. Aggression research is in a rapid state of development. The accelerating knowledge of neurotransmitter systems in the brain, their behavioural functions and the development of drugs which may specifically affect systems related to attack and defence is fruitfully combined with studies in which basic ethological observation and quantification techniques are used more routinely. Moreover, much of the experimental effort has finally applied some order to the initial chaos which afflicted the various experimental aggression models used in pharmacological, physiological and ethological research. This highly desirable trend not only leads to a better understanding of the phenomena studied and the terminologies employed, but it increases our awareness of the multiplicity of factors that are important, making it difficult to allow over hasty and simple generalizations. This book is a compilation of studies presented at the International Society for Research on Aggression meeting in Chicago 1986, in which leading investigators were invited to cover aspects of ethopharmacological aggression research in a wide variety of species, including studies on humans. The level to which ethological techniques have been incorporated into the various areas of research differs, as well as the knowledge and understanding of the neurotransmitter and experimental drug action on brain functioning in mammalian species. This naturally results in data which are not always easy to compare or to extrapolate between species but useful indicators are starting to emerge.