Strategies to Modify the Drug Release from Pharmaceutical Systems

Marcos Luciano Bruschi, Ph.D., is Professor of Pharmaceutics andPharmaceutical Technology in the Department of Pharmacy at the StateUniversity of Maringá (UEM), Paraná, Brazil. He gained a BSc in Pharmacy(1996 - UEM, Brazil), a MD in Pharmaceutical Sciences (2002 - State Universityof São Paulo - UNESP - Brazil) and a PhD in Pharmaceutical Sciences (2006 -University of São Paulo - USP - Brazil and School of Pharmacy, Queen’sUniversity of Belfast, Northern Ireland, UK). In 2013-2014, he is accomplishinga Post-Doctoral Degree in Pharmaceutics in the School of Pharmacy, Queen’sUniversity of Belfast (QUB - Northern Ireland, UK). He is registered with theBrazilian Pharmaceutical Society and, in 1998, took up a lectureship inPharmaceutics in the School of Pharmacy, UEM, Brazil. In 1999, he wasappointed as a senior lectureship and to a personal Chair in Pharmaceutics andPharmaceutical Technology in 2006. His research concerns the developmentand characterization of pharmaceutical dosage forms and drug deliverysystems, using natural or synthetic sources. Dr. Bruschi’s work has involved thedevelopment of novel drug delivery systems, with particular emphasis onmicro/nanoparticles, semisolids, bio/mucoadhesives, thermoresponsive systems,liquid crystaline phases, and natural products. He is the author of three Brazilianpatent requests and over 150 research papers/communications.

• Chapter 1 - General considerationsPharmaceutics: Safety, quality and efficacyConventional and alternative therapeutic regimensChapter 2 - Modification of drug releaseObjectivesAdvantagesDisadvantagesHistory Chapter 3 - Classification of therapeutic systems for drug delivery Passives, pre-programmed Actives, programmed and controlled externally Actives, self-programmableChapter 4 - Main mechanisms to control the drug release Diffusion SwellingErosion Osmosis Others Chapter 5 - Mathematical and physicochemical models of drug release Chapter 6 - Drug delivery systems: Principles, local of administration, materials, characterization, applications, advances and the use of natural products Matrix Tablets Suspensions Osmotic Pumps Micro/nanoparticles Micro/nanoemulsioned systems Liposomes and niosomes Floating Systems Systems with cyclodextrins Transdermal systems Bio/mucoadhesive Systems Liquid crystalline systems ImplantBiocompatible carriersOther systems