Markus J Seibel, MD PhD FRACP FAHMS, is Professor of Endocrinology at Sydney Uni¬versity. He is the Inaugural Director of the Bone Research Program at the ANZAC Research Institute, and heads the Department of Endocrinology & Meta¬bolism at Concord Hospital, Sydney. His research in musculoskeletal biology covers topics such as glucocorticoid signalling in bone and its effects on bone and systemic fuel metabolism and ageing; the biology of bone metastases; and the clinical efficacy of secondary fracture prevention programs. Prof Seibel has published over 400 scientific papers and is the editor of 8 books. In 2017, he has been elected to the Australian Academy of Health and Medical Sciences. Prof Seibel is a Past President of the Australia and New Zealand Bone & Mineral Society (ANZBMS), a Member of the Board of Directors, International Federation of Musculoskeletal Research Societies (IFMRS), and the Chair of the Australian National Alliance for Secondary Fracture Prevention. John P. Bilezikian, MD, the Dorothy L. and Daniel H. Silberberg Professor of Medicine and Professor of Pharmacology at the College of Physicians & Surgeons, Columbia University is Chief of the Division of Endocrinology and Director of the Metabolic Bone Diseases Program at Columbia University Medical Center. Dr. Bilezikian received his undergraduate training at Harvard College and his medical training at the College of Physicians & Surgeons. He completed four years of house staff training (internship, residency and Chief Residency) on the Medical Service at Columbia Presbyterian Medical Center. Dr. Bilezikian received his training in Metabolic Bone Diseases and in Endocrinology at the NIH in the Mineral Metabolism Branch under the tutelage of Dr. Gerald Aurbach. Dr. Bilezikian belongs to a number of professional societies including the American Society for Bone and Mineral Research, of which he served as President, 1995-1996 and the International Society of Clinical Densitometry, of which he served as President, 1999-2001. He serves on the Board of Governors of the International Osteoporosis Foundation (1998-present) and on its Committee of Scientific Advisors (2001-present). He is Chair of the Endocrine Fellows Foundation. He served as Editor-in-Chief of the Journal of Clinical Endocrinology and Metabolism (2000-2004) and as Senior Associate Editor of the Journal of Bone and Mineral Research (2008-2012). He is Executive Advisory Editor of Bone Research (2013-present). His books include Editor-in-Chief of The Parathyroids [1994, 2001, 2014], and co-editor of The Aging Skeleton (1999), Dynamics of Bone and Cartilage Metabolism (1999, 2006), Principles of Bone Biology (1996, 2002, 2008) and Osteoporosis in Men (2010). He served as co-chair of the last three NIH Workshops on Primary Hyperparathyroidism (2002, 2008, 2013). He is the recipient of the Distinguished Physician Award of the Endocrine Society, the Frederic C. Bartter Award of the American Society for Bone and Mineral Research (ASBMR) for Excellence in Clinical Research and the First Annual Global Leadership Award of the International Society of Clinical Densitometry. In 2009, he received the Gideon A. Rodan Excellence in Mentorship Award from the ASBMR. He received the Laureate Distinguished Educator Award of The Endocrine Society in 2014. In 2014, he was made honorary member of the Brazilian Society of Endocrinology and Metabolism. His publications number over 700.

Praise for the First Edition:"..The approach taken in this book--to consider the structural, functional, metabolic, and pathologic aspects of bone and cartilage in parallel--is a welcome departure and provides the reader with an unusual and interesting range of topics...Scientists and physicians who wish to cross the divide between bone and cartilage will find this book of considerable interest and value..." --Juliet E. Compston, University of Cambridge, UK in THE NEW ENGLAND JOURNAL OF MEDICINE

• PART I Components of the Organic Extracellular Matrix of Bone and Cartilage1. Structure, Biosynthesis and Gene Regulation of Collagens in Cartilage and Bone2. Fibrillogenesis and Maturation of Collagens3. Vitamin K Dependent Proteins of Bone and Cartilage4. Non-collagenous Proteins; Glycoproteins and Related Proteins5. Proteoglycans and Glycosaminoglycans6. Growth Factors7. Prostaglandins and Proinflammatory Cytokines 8. Integrins and Other Adhesion Molecules9. Alkaline Phosphatases10. Acid Phosphatases11. Matrix ProteinasesPART II Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage12. Mineralization, Structure and Function of Bone13. Bone Structure and Strength14. The Cells of Bone15. Signalling in bone16. Parathyroid Hormone: Structure, Function and Dynamic Actions17. Interaction of Parathyroid Hormone-Related Peptide with the Skeleton18. The Vitamin D Hormone and Its Nuclear Receptor: Mechanisms Involved in Bone Biology19. Sex Steroid Effects on Bone Metabolism20. Physiology of Calcium and Phosphate Homeostasis21. The Central Control of Bone Remodelling22. New Concepts in Bone Remodeling23. Products of Bone Collagen Metabolism24. Supramolecular Structure of Cartilage Matrix25. Products of Cartilage Metabolism26. Fluid Dynamics of the Joint Space and Trafficking of Matrix Products27. Transgenic Models of Bone DiseasePART III Markers of Bone and Cartilage Metabolism28. The Role of Genetic Variation in Osteoporosis29. Measurement of Calcium, Phosphate and Magnesium30. Measurement of Parathyroid Hormone 31. New Horizons for Assessment of Vitamin D Status in Man32. Measurement of Biochemical Markers of Bone Formation33. Measurement of Biochemical Markers of Bone Resorption34. Variability in the measurement of biochemical markers of bone turnover35. Validation of Biochemical Markers of Bone Turnover36. Genetic Markers of Joint Disease37. Body Fluid Markers of Cartilage Metabolism38. Laboratory Assessment of Postmenopausal Osteoporosis39. Monitoring of Anabolic Treatment40. Monitoring of anti-resorptive treatment41. Age-Related Osteoporosis and Skeletal Markers of Bone Turnover42. Osteoporosis in Men 43. Steroid-Induced Osteoporosis44. Transplantation Osteoporosis: Biochemical Correlates of Pathogenesis and Treatment45. Secondary Osteoporosis46. Osteomalacia and Rickets47. Assessment of Bone and Joint Diseases: Renal Osteodystrophy48. Primary Hyperparathyroidism 49. Paget’s Disease of Bone50. Metastatic Bone Disease51. Rare Bone Diseases52. Osteogenesis Imperfecta53. Rheumatoid Arthritis and Other Inflammatory Joint Pathologies54. Osteoarthritis and Degenerative Spine Pathologies

Markus J Seibel, MD PhD FRACP FAHMS, is Professor of Endocrinology at Sydney Uni¬versity. He is the Inaugural Director of the Bone Research Program at the ANZAC Research Institute, and heads the Department of Endocrinology & Meta¬bolism at Concord Hospital, Sydney. His research in musculoskeletal biology covers topics such as glucocorticoid signalling in bone and its effects on bone and systemic fuel metabolism and ageing; the biology of bone metastases; and the clinical efficacy of secondary fracture prevention programs. Prof Seibel has published over 400 scientific papers and is the editor of 8 books. In 2017, he has been elected to the Australian Academy of Health and Medical Sciences. Prof Seibel is a Past President of the Australia and New Zealand Bone & Mineral Society (ANZBMS), a Member of the Board of Directors, International Federation of Musculoskeletal Research Societies (IFMRS), and the Chair of the Australian National Alliance for Secondary Fracture Prevention. John P. Bilezikian, MD, the Dorothy L. and Daniel H. Silberberg Professor of Medicine and Professor of Pharmacology at the College of Physicians & Surgeons, Columbia University is Chief of the Division of Endocrinology and Director of the Metabolic Bone Diseases Program at Columbia University Medical Center. Dr. Bilezikian received his undergraduate training at Harvard College and his medical training at the College of Physicians & Surgeons. He completed four years of house staff training (internship, residency and Chief Residency) on the Medical Service at Columbia Presbyterian Medical Center. Dr. Bilezikian received his training in Metabolic Bone Diseases and in Endocrinology at the NIH in the Mineral Metabolism Branch under the tutelage of Dr. Gerald Aurbach. Dr. Bilezikian belongs to a number of professional societies including the American Society for Bone and Mineral Research, of which he served as President, 1995-1996 and the International Society of Clinical Densitometry, of which he served as President, 1999-2001. He serves on the Board of Governors of the International Osteoporosis Foundation (1998-present) and on its Committee of Scientific Advisors (2001-present). He is Chair of the Endocrine Fellows Foundation. He served as Editor-in-Chief of the Journal of Clinical Endocrinology and Metabolism (2000-2004) and as Senior Associate Editor of the Journal of Bone and Mineral Research (2008-2012). He is Executive Advisory Editor of Bone Research (2013-present). His books include Editor-in-Chief of The Parathyroids [1994, 2001, 2014], and co-editor of The Aging Skeleton (1999), Dynamics of Bone and Cartilage Metabolism (1999, 2006), Principles of Bone Biology (1996, 2002, 2008) and Osteoporosis in Men (2010). He served as co-chair of the last three NIH Workshops on Primary Hyperparathyroidism (2002, 2008, 2013). He is the recipient of the Distinguished Physician Award of the Endocrine Society, the Frederic C. Bartter Award of the American Society for Bone and Mineral Research (ASBMR) for Excellence in Clinical Research and the First Annual Global Leadership Award of the International Society of Clinical Densitometry. In 2009, he received the Gideon A. Rodan Excellence in Mentorship Award from the ASBMR. He received the Laureate Distinguished Educator Award of The Endocrine Society in 2014. In 2014, he was made honorary member of the Brazilian Society of Endocrinology and Metabolism. His publications number over 700.

Praise for the First Edition:"..The approach taken in this book--to consider the structural, functional, metabolic, and pathologic aspects of bone and cartilage in parallel--is a welcome departure and provides the reader with an unusual and interesting range of topics...Scientists and physicians who wish to cross the divide between bone and cartilage will find this book of considerable interest and value..." --Juliet E. Compston, University of Cambridge, UK in THE NEW ENGLAND JOURNAL OF MEDICINE

• PART I Components of the Organic Extracellular Matrix of Bone and Cartilage1. Structure, Biosynthesis and Gene Regulation of Collagens in Cartilage and Bone2. Fibrillogenesis and Maturation of Collagens3. Vitamin K Dependent Proteins of Bone and Cartilage4. Non-collagenous Proteins; Glycoproteins and Related Proteins5. Proteoglycans and Glycosaminoglycans6. Growth Factors7. Prostaglandins and Proinflammatory Cytokines 8. Integrins and Other Adhesion Molecules9. Alkaline Phosphatases10. Acid Phosphatases11. Matrix ProteinasesPART II Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage12. Mineralization, Structure and Function of Bone13. Bone Structure and Strength14. The Cells of Bone15. Signalling in bone16. Parathyroid Hormone: Structure, Function and Dynamic Actions17. Interaction of Parathyroid Hormone-Related Peptide with the Skeleton18. The Vitamin D Hormone and Its Nuclear Receptor: Mechanisms Involved in Bone Biology19. Sex Steroid Effects on Bone Metabolism20. Physiology of Calcium and Phosphate Homeostasis21. The Central Control of Bone Remodelling22. New Concepts in Bone Remodeling23. Products of Bone Collagen Metabolism24. Supramolecular Structure of Cartilage Matrix25. Products of Cartilage Metabolism26. Fluid Dynamics of the Joint Space and Trafficking of Matrix Products27. Transgenic Models of Bone DiseasePART III Markers of Bone and Cartilage Metabolism28. The Role of Genetic Variation in Osteoporosis29. Measurement of Calcium, Phosphate and Magnesium30. Measurement of Parathyroid Hormone 31. New Horizons for Assessment of Vitamin D Status in Man32. Measurement of Biochemical Markers of Bone Formation33. Measurement of Biochemical Markers of Bone Resorption34. Variability in the measurement of biochemical markers of bone turnover35. Validation of Biochemical Markers of Bone Turnover36. Genetic Markers of Joint Disease37. Body Fluid Markers of Cartilage Metabolism38. Laboratory Assessment of Postmenopausal Osteoporosis39. Monitoring of Anabolic Treatment40. Monitoring of anti-resorptive treatment41. Age-Related Osteoporosis and Skeletal Markers of Bone Turnover42. Osteoporosis in Men 43. Steroid-Induced Osteoporosis44. Transplantation Osteoporosis: Biochemical Correlates of Pathogenesis and Treatment45. Secondary Osteoporosis46. Osteomalacia and Rickets47. Assessment of Bone and Joint Diseases: Renal Osteodystrophy48. Primary Hyperparathyroidism 49. Paget’s Disease of Bone50. Metastatic Bone Disease51. Rare Bone Diseases52. Osteogenesis Imperfecta53. Rheumatoid Arthritis and Other Inflammatory Joint Pathologies54. Osteoarthritis and Degenerative Spine Pathologies