John P. Bilezikian - Böcker

This updated edition is a comprehensive treatise that spans the complete range of basic biochemistry of bone and cartilage components to the clinical evaluation of disease markers in bone and joint disorders. With contributions from over 75 international experts, Dynamics of Bone and Cartilage Metabolism, Second Edition, is indispensable reading for those involved in skeletal research as well as for rheumatologists, endocrinologists, clinical biochemists, and other clinical disciplines participating in the management of patients with bone and cartilage diseases. Part I provides an up-to-date account of current knowledge of the structure, biosynthesis and molecular biology of the major tissue components Part II covers the organizational structure and cellular metabolism of bone and cartilage Part III deals with the utility of components specific to bone and cartilage as biomarkers of health and disease

The Aging Skeleton is a comprehensive and timely book on all aspects of the skeleton as it ages, including basic mechanisms and pathways as well as pathobiology. Chapters cover general aspects and models of aging, determinants and maintenance of peak bone mass, mechanisms of age-related bone loss, quantifiable manifestations of age-related bone loss, fractures, and therapeutics. Covers all aspects of the aging skeleton in one comprehensive volume Looks at the influence of genetics, nutrition, environment, hormones, and other factors on bone mass Provides a thorough discussion of fractures, one of the major consequences of the aging skeleton Reviews current therapeutic approaches and methods Written by internationally renowned authors and edited by leaders in the field Is the only book available on this subject

Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders.

Since the publication of the first edition, the U.S. Surgeon General released the first-ever report on bone health and osteoporosis in October 2004. This report focuses even more attention on the devastating impact osteoporosis has on millions of lives. According to the National Osteoporosis Foundation, 2 million American men have osteoporosis, and another 12 million are at risk for this disease. Yet despite the large number of men affected, the lack of awareness by doctors and their patients puts men at a higher risk that the condition may go undiagnosed and untreated. It is estimated that one-fifth to one-third of all hip fractures occur in men.

This second edition brings on board John Bilezikian and Dirk Vanderschueren as editors with Eric Orwoll. The table of contents is more than doubling with 58 planned chapters. The format is larger - 8.5 x 11. This edition of Osteoporosis in Men brings together even more eminent investigators and clinicians to interpret developments in this growing field, and describe state-of-the-art research as well as practical approaches to diagnosis, prevention and therapy.

Brings together more eminent investigators and clinicians to interpret developments in this growing field Describes state-of-the-art research as well as practical approaches to diagnosis, prevention and therapy There is no book on the market that covers osteoporosis in men as comprehensively as this book

The third edition of The Parathyroids, led by a new stellar editorial team,�has been�thoroughly updated to reflect the considerable advances in just about every aspect of PTH biology over the past decade. It continues to be the authoritative reference that spans the basic science of parathyroid hormone treatment to major clinical disorders in a superb, single compendium. This translational resource is invaluable to graduate students, fellows, researchers, and research clinicians in the fields of endocrinology, bone biology, osteology, and rheumatology.

Contains chapters and information on noninvasive imaging, fracture healing, secondary diseases such as CKD, Vitamin D, cell signaling pathways, vascular calcification, as well as advances in genetics/genomics Includes essential updates on the critical importance of Vitamin D insufficiency and its relationship to secondary hyperparathyroidism Offers new insights into the underlying mechanisms of parathyroid hormone actions on osteocytes and sclerostin Examines essential updates in the understanding of secondary hyperparathyroidism associated with chronic kidney disease, facture healing, and vascular disease

Preface from the first edition (1996): "The world of modern science is undergoing a number of spectacular events that are redefining our understanding of ourselves. As with any revolution, we should take stock of where we have been, where we are, and where we are going. Our special world of bone biology is participating in and taking advantage of the larger global revolution in modern science… we assembled experts from all over the world and asked them to focus on the current state of knowledge and the prospects for new knowledge in their area of expertise. To this end,　Principles of Bone Biology　was conceived." - John P. Bilezikian, Lawrence G. Raisz, Gideon A. RodanPraise for the previous edition: "Students, teachers, and practitioners will benefit from reading it, and investigators will use it as a reference work; it will certainly be consulted frequently." --The New England Journal of MedicineFor over two decades, "Big Gray" has been the go-to repository of knowledge in the disciplines related to bone and mineral metabolism. The fourth edition is a must-have for students new to the field; young investigators at the graduate or postgraduate level beginning their research careers; established scientists who need to keep up with the changing nature of the field, looking to enrich their own research programs, or who are changing their career direction; clinicians who want ready access to up-to-date relevant basic science.This new edition builds on the successful formula from previous editions, taking the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics. Principles of Bone Biology, Fourth Edition provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. Bone research continues to generate enormous attention, due to the broad public health implications of osteoporosis and related bone disorders. This classic, fully updated, two volume reference is designed for anyone involved in the study of bone biology.

In the last several years, reports of patients treated with bisphosphonates (primarily those delivered intravenously) have emerged associating their use with osteonecrosis of the jaw (ONJ). More than a thousand cases of bisphosphonate-associated ONJ have been identified since the first cases were reported in 2001. In these, ONJ rarely occurs "spontaneously"; the vast majority have been associated as a consequence to oral surgical procedures. Although most of the reports of ONJ have occurred in patients following the use of high dose IV therapy for metastatic bone disease, there are also reports of ONJ in patients taking oral bisphosphonates. Since millions of patients take oral bisphosphonates for the treatment of osteoporosis, it is timely to review what is known and needs to be learned about this emerging issue in patient care—to develop a consensus on the definition of ONJ, as well as to explore potential risk factors and pathogenic mechanisms of ONJ and to explore strategies to move research forward. This volumes seeks to improve awareness of the condition and the need for increased screening and improved diagnosis of ONJ. It also explores possible treatment options for ONJ to help guide future areas for research.NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1749-6632.ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.